Title:
PHARMACEUTICAL COMPOSITION COMPRISING ALLOPURINOL, FEBUXOSTAT, OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF FOR PREVENTING OR TREATING CARDIOVASCULAR DISEASE OF SUBJECT HAVING HIGH BLOOD URIC ACID LEVEL
Document Type and Number:
WIPO Patent Application WO/2023/149701
Kind Code:
A1
Abstract:
The present invention provides a pharmaceutical composition comprising a therapeutically effective amount of allopurinol, febuxostat, or a pharmaceutically acceptable salt thereof as an active ingredient for preventing or treating cardiovascular disease, in which the composition is administered to a subject having a blood uric acid level of 6 mg/dl or higher to reduce the blood uric acid level of the subject to less than 6 mg/dl. Therefore, the pharmaceutical composition according to the present invention exhibits an excellent effect on xanthine oxidase inhibitor and is administered to selected subjects to effectively treat or prevent cardiovascular disease.
Inventors:
GHANG BYEONG ZU (KR)
Application Number:
PCT/KR2023/001333
Publication Date:
August 10, 2023
Filing Date:
January 30, 2023
Export Citation:
Assignee:
INDREAM HEALTHCARE INC (KR)
International Classes:
A61K31/519; A61K31/426; A61P9/00
Foreign References:
| KR20210069685A | 2021-06-11 | |||
| US20120135078A1 | 2012-05-31 | |||
| US20030158213A1 | 2003-08-21 |
Other References:
SUZUKI SATOSHI, YOSHIHISA AKIOMI, YOKOKAWA TETSURO, KOBAYASHI ATSUSHI, YAMAKI TAKAYOSHI, KUNII HIROYUKI, NAKAZATO KAZUHIKO, TSUDA : "Comparison between febuxostat and allopurinol uric acid-lowering therapy in patients with chronic heart failure and hyperuricemia: a multicenter randomized controlled trial", JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, CAMBRIDGE MEDICAL PUBLICATIONS LTD., GB, vol. 49, no. 12, 1 December 2021 (2021-12-01), GB , pages 030006052110627, XP093082535, ISSN: 0300-0605, DOI: 10.1177/03000605211062770
GOICOECHEA MARIAN, DE VINUESA SOLEDAD GARCÍA, VERDALLES URSULA, RUIZ-CARO CARIDAD, AMPUERO JARA, RINCÓN ABRAHAM, ARROYO DAVID, LUÑ: "Effect of Allopurinol in Chronic Kidney Disease Progression and Cardiovascular Risk", CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 5, no. 8, 1 August 2010 (2010-08-01), pages 1388 - 1393, XP093082536, ISSN: 1555-9041, DOI: 10.2215/CJN.01580210
GOICOECHEA MARIAN, DE VINUESA SOLEDAD GARCÍA, VERDALLES URSULA, RUIZ-CARO CARIDAD, AMPUERO JARA, RINCÓN ABRAHAM, ARROYO DAVID, LUÑ: "Effect of Allopurinol in Chronic Kidney Disease Progression and Cardiovascular Risk", CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 5, no. 8, 1 August 2010 (2010-08-01), pages 1388 - 1393, XP093082536, ISSN: 1555-9041, DOI: 10.2215/CJN.01580210
Attorney, Agent or Firm:
LEE & KO IP (KR)
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