Title:
PHARMACEUTICAL COMPOSITION COMPRISING ANTIBODY-DRUG CONJUGATE, AND USE OF PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2022/068914
Kind Code:
A1
Abstract:
Provided are a pharmaceutical composition comprising an antibody-drug conjugate, and use of the pharmaceutical composition. Specifically provided is a pharmaceutical composition, comprising an anti-claudin antibody-drug conjugate.
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Inventors:
WANG ZHIWAN (CN)
WU TINGTING (CN)
LIU XUN (CN)
WU TINGTING (CN)
LIU XUN (CN)
Application Number:
PCT/CN2021/122031
Publication Date:
April 07, 2022
Filing Date:
September 30, 2021
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
C07K16/30; A61K39/395; A61P35/00; C12N15/13
Domestic Patent References:
| WO2020043044A1 | 2020-03-05 | |||
| WO2016166122A1 | 2016-10-20 | |||
| WO2016165762A1 | 2016-10-20 | |||
| WO2020063676A1 | 2020-04-02 |
Foreign References:
| CN110857322A | 2020-03-03 | |||
| CN110862454A | 2020-03-06 | |||
| CN111433188A | 2020-07-17 | |||
| CN111295389A | 2020-06-16 | |||
| CN202011061863A | 2020-09-30 | |||
| CN202111069020A | 2021-09-13 | |||
| US20050238649A1 | 2005-10-27 | |||
| US5208020A | 1993-05-04 |
Other References:
CAO YUNXIN; ZHANG SONG; YANG ANGANG: "Expression of Claudin 18 in pancreatic cancer cells", CHINESE JOURNAL OF CELLULAR AND MOLECULAR IMMUNOLOGY, vol. 25, no. 12, 18 December 2009 (2009-12-18), pages 1202 - 1203+1206, XP055917892, ISSN: 1007-8738
HUA JIANG, SHI ZHIMIN, WANG PENG, WANG CONG, YANG LINLIN, DU GUOXIU, ZHANG HONGHONG, SHI BIZHI, JIA JIE, LI QIXIANG, WANG HUAMAO, : "Claudin18.2-Specific Chimeric Antigen Receptor Engineered T Cells for the Treatment of Gastric Cancer", JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 111, no. 4, 1 January 2019 (2019-01-01), GB , pages 409 - 418, XP055642983, ISSN: 0027-8874, DOI: 10.1093/jnci/djy134
J. BIOL. CHEM., vol. 243, 1968, pages 3558
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI USA, vol. 85, 1988, pages 5879 - 5883
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
AL-LAZIKANI ET AL., JMB, vol. 273, 1997, pages 927 - 948
LEFRANC M.P., IMMUNOLOGIST, vol. 7, 1999, pages 132 - 136
LEFRANC, M.P. ET AL., DEV. COMP. IMMUNOL., vol. 27, 2003, pages 55 - 77
WATSON ET AL.: "Molecular Biology of the Gene", 1987, THE BENJAMIN/CUMMINGS PUB. CO., pages: 224
CHARI ET AL., CANCER RESEARCH, vol. 52, 1992, pages 127 - 131
"Antibodies: A Laboratory Manual and Molecular Cloning: A Laboratory Manual", COLD SPRING HARBOR LABORATORY
See also references of EP 4223785A4
HUA JIANG, SHI ZHIMIN, WANG PENG, WANG CONG, YANG LINLIN, DU GUOXIU, ZHANG HONGHONG, SHI BIZHI, JIA JIE, LI QIXIANG, WANG HUAMAO, : "Claudin18.2-Specific Chimeric Antigen Receptor Engineered T Cells for the Treatment of Gastric Cancer", JOURNAL OF THE NATIONAL CANCER INSTITUTE, vol. 111, no. 4, 1 January 2019 (2019-01-01), GB , pages 409 - 418, XP055642983, ISSN: 0027-8874, DOI: 10.1093/jnci/djy134
J. BIOL. CHEM., vol. 243, 1968, pages 3558
BIRD ET AL., SCIENCE, vol. 242, 1988, pages 423 - 426
HUSTON ET AL., PROC. NATL. ACAD. SCI USA, vol. 85, 1988, pages 5879 - 5883
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, PUBLIC HEALTH SERVICE, NATIONAL INSTITUTES OF HEALTH
AL-LAZIKANI ET AL., JMB, vol. 273, 1997, pages 927 - 948
LEFRANC M.P., IMMUNOLOGIST, vol. 7, 1999, pages 132 - 136
LEFRANC, M.P. ET AL., DEV. COMP. IMMUNOL., vol. 27, 2003, pages 55 - 77
WATSON ET AL.: "Molecular Biology of the Gene", 1987, THE BENJAMIN/CUMMINGS PUB. CO., pages: 224
CHARI ET AL., CANCER RESEARCH, vol. 52, 1992, pages 127 - 131
"Antibodies: A Laboratory Manual and Molecular Cloning: A Laboratory Manual", COLD SPRING HARBOR LABORATORY
See also references of EP 4223785A4
Attorney, Agent or Firm:
GE CHENG & CO., LTD (CN)
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