Title:
PHARMACEUTICAL COMPOSITION COMPRISING C-MET ANTIBODY-DRUG CONJUGATE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/223958
Kind Code:
A1
Abstract:
A stable c-Met antibody-drug conjugate (c-Met ADC) formulation and use thereof in medicine. Said formulation comprises c-Met ADC, a buffer, and can also comprise at least one stabilizer, and optionally a surfactant. The c-Met ADC formulation of the present invention can effectively inhibit the aggregation and isomerization of antibodies, and prevent the degradation of an antibody product therein, being a stable injectable pharmaceutical formulation.
Inventors:
FANG JINGJING (CN)
YAN ZHEN (CN)
TONG GUIMEI (CN)
LIU XUN (CN)
YAN ZHEN (CN)
TONG GUIMEI (CN)
LIU XUN (CN)
Application Number:
PCT/CN2018/089955
Publication Date:
December 13, 2018
Filing Date:
June 05, 2018
Export Citation:
Assignee:
JIANGSU HENGRUI MEDICINE CO (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
SHANGHAI HENGRUI PHARMACEUTICAL CO LTD (CN)
International Classes:
A61K47/68; A61K39/395; A61P35/00; C07K16/28
Domestic Patent References:
| WO2016042412A1 | 2016-03-24 | |||
| WO2016165580A1 | 2016-10-20 | |||
| WO2016165580A1 | 2016-10-20 | |||
| WO2013072813A2 | 2013-05-23 |
Foreign References:
| CN106456794A | 2017-02-22 | |||
| CN106188293A | 2016-12-07 | |||
| CN105163763A | 2015-12-16 | |||
| CN201710417725A | 2017-06-06 | |||
| CN201710551046A | 2017-07-07 | |||
| CN103781493A | 2014-05-07 | |||
| CN105050618A | 2015-11-11 |
Other References:
J. BIOL. CHEM., vol. 243, 1968, pages 3558
KABAT, E A ET AL.: "Sequences of Proteins of Immunological Interest", 1991
WATSON ET AL.: "Molecular Biology of the Gene", 1987, THE BENJARNIN/CUMMINGS PUB. CO., pages: 224
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1977, pages 3389 - 3402
KABAT, E A ET AL.: "Sequences of Proteins of Immunological Interest", 1991
WATSON ET AL.: "Molecular Biology of the Gene", 1987, THE BENJARNIN/CUMMINGS PUB. CO., pages: 224
ALTSCHUL ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
ALTSCHUL ET AL., NUCLEIC ACIDS RES., vol. 25, 1977, pages 3389 - 3402
Attorney, Agent or Firm:
SHANGHAI BESHINING LAW OFFICE (CN)
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