Title:
PHARMACEUTICAL COMPOSITION COMPRISING CURCUMIN AND GINSENOSIDE, AND FORMULATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/153861
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition comprising curcumin and ginsenoside, and a formulation comprising same. Using curcumin and ginsenoids according to the present invention in combination with butyric acid and sucralfate restores cell growth, mobility, and endothelial cell tube-forming ability reduced by irradiation, and inhibits an inflammatory response induced in macrophages by LPS treatment. In addition, it was confirmed that, when an irradiated mouse is topically treated with the formulation according to the present invention comprising the compounds, intestinal epithelial tissue damaged by irradiation is restored and the expression of inflammatory cytokines in the intestinal tissue is suppressed. Furthermore, a mixture of a ginseng extract and a turmeric extract also restored the intestinal epithelial tissue damaged by irradiation. Therefore, the pharmaceutical composition comprising curcumin, ginsenoid, butyric acid, and sucralfate, or the pharmaceutical composition comprising a mixture of a ginseng extract and a turmeric extract, and the formulation according to the present invention comprising same can be utilized for treating radiation proctitis.
Inventors:
LEE TAE YONG (KR)
KIM MIN SUNG (KR)
YANG SU JEONG (KR)
LEE RYUNG-AH (KR)
KIM SEONG-EUN (KR)
KIM MIN SUNG (KR)
YANG SU JEONG (KR)
LEE RYUNG-AH (KR)
KIM SEONG-EUN (KR)
Application Number:
PCT/KR2023/001992
Publication Date:
August 17, 2023
Filing Date:
February 10, 2023
Export Citation:
Assignee:
CORESTEMCHEMON INC (KR)
UNIV EWHA IND COLLABORATION (KR)
UNIV EWHA IND COLLABORATION (KR)
International Classes:
A61K31/12; A61K9/06; A61K31/606; A61K31/635; A61K31/704; A61K47/32; A61K47/36; A61P1/00; A61P17/16; A61P29/00
Domestic Patent References:
| WO1995011699A1 | 1995-05-04 | |||
| WO1998001112A1 | 1998-01-15 |
Other References:
MERYEM AKPOLAT ; MEHMET KANTER ; MUSTAFA CEM UZAL: "Protective effects of curcumin against gamma radiation-induced ileal mucosal damage", ARCHIVES OF TOXICOLOGY, SPRINGER-VERLAG, BERLIN, DE, vol. 83, no. 6, 27 August 2008 (2008-08-27), DE , pages 609 - 617, XP019701769, ISSN: 1432-0738
TINGTING HU; HONGYI CAI.: " Experimental study of ginsenoside Rg3 in the treatment of acute radiation proctitis in rat models. ", CHINESE JOURNAL OF RADIATION ONCOLOGY., vol. 11, no. 6, 15 November 2019 (2019-11-15), pages 854 - 857, XP009547912, ISSN: 1004-4221
KENNEDY GREGORY, HEISE CHARLES: "Radiation Colitis and Proctitis", CLINICS IN COLON & RECTAL SURGERY, THIEME MEDICAL PUBLISHERS, US, vol. 20, no. 1, 1 February 2007 (2007-02-01), US , pages 064 - 072, XP093082849, ISSN: 1531-0043, DOI: 10.1055/s-2007-970202
LIZA VECCHI BRUMATTI, ANNALISA MARCUZZI, PAOLA TRICARICO, VALENTINA ZANIN, MARTINA GIRARDELLI, ANNA BIANCO: "Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments", MOLECULES, SPRINGER VERLAG, BERLIN, DE, vol. 19, no. 12, 1 December 2014 (2014-12-01), DE , pages 21127 - 21153, XP055523238, ISSN: 1433-1373, DOI: 10.3390/molecules191221127
KANG ZENGPING, ZHONGA YOUBAO, WU TIANTIAN, HUANG JIAQI, ZHAO HAIMEI, LIU DUANYONG: "Ginsenoside from ginseng: a promising treatment for inflammatory bowel disease", PHARMACOLOGICAL REPORTS, POLSKA AKADEMIA NAUK, INSTYTUT FARMAKOLOGII, KRAKOW, PL, vol. 73, no. 3, 1 June 2021 (2021-06-01), PL , pages 700 - 711, XP093082851, ISSN: 1734-1140, DOI: 10.1007/s43440-020-00213-z
VERMA VIVEK: "Relationship and interactions of curcumin with radiation therapy", WORLD JOURNAL OF CLINICAL ONCOLOGY, BAISHIDENG PUBLISHING GROUP CO., LIMITED, US, vol. 7, no. 3, 10 June 2016 (2016-06-10), US , pages 275 - 283, XP093082852, ISSN: 2218-4333, DOI: 10.5306/wjco.v7.i3.275
ZHANG QIKE, BAIXIA YANG, XIAOGANG ZHAI, KUILING ZHAO, ZHIJUN WU, QIWEI ZHU, JINLIN ZHANG, XIAOFANG WEI, YINGLING ZHAO, JING CAI, Z: "Protective effects of ginsenosides Rb2 on irradiation-induced hematopoietic system injury in the mice. ", INTERNATIONAL JOURNAL OF PHARMACOLOGY, vol. 10, no. 8, 1 January 2014 (2014-01-01), pages 524 - 527, XP093082855
HAE-JUNE LEE, SE-RA KIM, SUNG-HO KIM: "Morphological evaluation on the effect of panaxadiol series ginsenosides in irradiated mice", KOREAN JOURNAL OF VETERINARY RESEARCH, THE KOREAN SOCIETY OF VETERINARY SCIENCE, KR, vol. 44, no. 2, 1 January 2004 (2004-01-01), KR , pages 179 - 184, XP009547911, ISSN: 2234-134X
ZOI VASILIKI, GALANI VASILIKI, TSEKERIS PERICLES, KYRITSIS ATHANASIOS P., ALEXIOU GEORGE A.: "Radiosensitization and Radioprotection by Curcumin in Glioblastoma and Other Cancers", BIOMEDICINES, vol. 10, no. 2, 28 January 2022 (2022-01-28), pages 312, XP093082856, DOI: 10.3390/biomedicines10020312
CHEN SUFANG, LI XIANG, WANG YANLING, MU PANWEI, CHEN CHAOJIN, HUANG PINJIE, LIU DEZHAO: "Ginsenoside Rb1 attenuates intestinal ischemia/reperfusion‑induced inflammation and oxidative stress via activation of the PI3K/Akt/Nrf2 signaling pathway", MOLECULAR MEDICINE REPORTS, SPANDIDOS PUBLICATIONS, GR, 1 January 2019 (2019-01-01), GR , pages 3633 - 3641, XP093082860, ISSN: 1791-2997, DOI: 10.3892/mmr.2019.10018
SHABEEB DHEYAULDEEN, MUSA AHMED ELEOJO, ABD ALI HAYDER SHABEEB, NAJAFI MASOUD: "Curcumin Protects Against Radiotherapy-Induced Oxidative Injury to the Skin", DRUG DESIGN, DEVELOPMENT AND THERAPY, vol. 14, 1 August 2020 (2020-08-01), pages 3159 - 3163, XP093082861, DOI: 10.2147/DDDT.S265228
TINGTING HU; HONGYI CAI.: " Experimental study of ginsenoside Rg3 in the treatment of acute radiation proctitis in rat models. ", CHINESE JOURNAL OF RADIATION ONCOLOGY., vol. 11, no. 6, 15 November 2019 (2019-11-15), pages 854 - 857, XP009547912, ISSN: 1004-4221
KENNEDY GREGORY, HEISE CHARLES: "Radiation Colitis and Proctitis", CLINICS IN COLON & RECTAL SURGERY, THIEME MEDICAL PUBLISHERS, US, vol. 20, no. 1, 1 February 2007 (2007-02-01), US , pages 064 - 072, XP093082849, ISSN: 1531-0043, DOI: 10.1055/s-2007-970202
LIZA VECCHI BRUMATTI, ANNALISA MARCUZZI, PAOLA TRICARICO, VALENTINA ZANIN, MARTINA GIRARDELLI, ANNA BIANCO: "Curcumin and Inflammatory Bowel Disease: Potential and Limits of Innovative Treatments", MOLECULES, SPRINGER VERLAG, BERLIN, DE, vol. 19, no. 12, 1 December 2014 (2014-12-01), DE , pages 21127 - 21153, XP055523238, ISSN: 1433-1373, DOI: 10.3390/molecules191221127
KANG ZENGPING, ZHONGA YOUBAO, WU TIANTIAN, HUANG JIAQI, ZHAO HAIMEI, LIU DUANYONG: "Ginsenoside from ginseng: a promising treatment for inflammatory bowel disease", PHARMACOLOGICAL REPORTS, POLSKA AKADEMIA NAUK, INSTYTUT FARMAKOLOGII, KRAKOW, PL, vol. 73, no. 3, 1 June 2021 (2021-06-01), PL , pages 700 - 711, XP093082851, ISSN: 1734-1140, DOI: 10.1007/s43440-020-00213-z
VERMA VIVEK: "Relationship and interactions of curcumin with radiation therapy", WORLD JOURNAL OF CLINICAL ONCOLOGY, BAISHIDENG PUBLISHING GROUP CO., LIMITED, US, vol. 7, no. 3, 10 June 2016 (2016-06-10), US , pages 275 - 283, XP093082852, ISSN: 2218-4333, DOI: 10.5306/wjco.v7.i3.275
ZHANG QIKE, BAIXIA YANG, XIAOGANG ZHAI, KUILING ZHAO, ZHIJUN WU, QIWEI ZHU, JINLIN ZHANG, XIAOFANG WEI, YINGLING ZHAO, JING CAI, Z: "Protective effects of ginsenosides Rb2 on irradiation-induced hematopoietic system injury in the mice. ", INTERNATIONAL JOURNAL OF PHARMACOLOGY, vol. 10, no. 8, 1 January 2014 (2014-01-01), pages 524 - 527, XP093082855
HAE-JUNE LEE, SE-RA KIM, SUNG-HO KIM: "Morphological evaluation on the effect of panaxadiol series ginsenosides in irradiated mice", KOREAN JOURNAL OF VETERINARY RESEARCH, THE KOREAN SOCIETY OF VETERINARY SCIENCE, KR, vol. 44, no. 2, 1 January 2004 (2004-01-01), KR , pages 179 - 184, XP009547911, ISSN: 2234-134X
ZOI VASILIKI, GALANI VASILIKI, TSEKERIS PERICLES, KYRITSIS ATHANASIOS P., ALEXIOU GEORGE A.: "Radiosensitization and Radioprotection by Curcumin in Glioblastoma and Other Cancers", BIOMEDICINES, vol. 10, no. 2, 28 January 2022 (2022-01-28), pages 312, XP093082856, DOI: 10.3390/biomedicines10020312
CHEN SUFANG, LI XIANG, WANG YANLING, MU PANWEI, CHEN CHAOJIN, HUANG PINJIE, LIU DEZHAO: "Ginsenoside Rb1 attenuates intestinal ischemia/reperfusion‑induced inflammation and oxidative stress via activation of the PI3K/Akt/Nrf2 signaling pathway", MOLECULAR MEDICINE REPORTS, SPANDIDOS PUBLICATIONS, GR, 1 January 2019 (2019-01-01), GR , pages 3633 - 3641, XP093082860, ISSN: 1791-2997, DOI: 10.3892/mmr.2019.10018
SHABEEB DHEYAULDEEN, MUSA AHMED ELEOJO, ABD ALI HAYDER SHABEEB, NAJAFI MASOUD: "Curcumin Protects Against Radiotherapy-Induced Oxidative Injury to the Skin", DRUG DESIGN, DEVELOPMENT AND THERAPY, vol. 14, 1 August 2020 (2020-08-01), pages 3159 - 3163, XP093082861, DOI: 10.2147/DDDT.S265228
Attorney, Agent or Firm:
RYU, Jong Woo et al. (KR)
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