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Title:
PHARMACEUTICAL COMPOSITION COMPRISING ELIGLUSTAT
Document Type and Number:
WIPO Patent Application WO/2019/030645
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition comprising glucosylceramide synthase inhibitor and a one or more pharmaceutically acceptable excipients. The present invention specifically relates to a sublingual pharmaceutical composition of eliglustat or a pharmaceutically acceptable salt thereof and a one or more pharmaceutically acceptable excipients. Moreover, the present invention further relates to a pharmaceutical composition of eliglustat or a pharmaceutically acceptable salt thereof which is used in the treatment of individual with lysozymal storage diseases selected from the group consisting of, Gaucher disease, Sphingolipidoses, Farber disease, Krabbe disease, Fabry disease, Schindler disease, Tay–Sachs disease and Niemann-Pick disease.

Inventors:
PUROHIT PARVA YOGESHCHANDRA (IN)
VASANANI PARAS RASIKLAL (IN)
AGRAWAL VIKAS MAHESHBHAI (IN)
SUCHAK KISHAN PRADIPBHAI (IN)
Application Number:
PCT/IB2018/055900
Publication Date:
February 14, 2019
Filing Date:
August 06, 2018
Export Citation:
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Assignee:
KASHIV PHARMA LLC (US)
International Classes:
A61K31/4025
Domestic Patent References:
WO2016038616A12016-03-17
Foreign References:
US20160331693A12016-11-17
US7067115B22006-06-27
US20130137743A12013-05-30
US20150250856A12015-09-10
US20150038594A12015-02-05
Other References:
BALWANI ET AL.: "Recommendations for the use of eliglustat in the treatment of adults with Gaucher disease type 1 in the United States", MOLECULAR GENETICS AND METABOLISM, vol. 117, no. 2, 2016, pages 95 - 103, XP029416638
See also references of EP 3664798A4
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