Title:
PHARMACEUTICAL COMPOSITION COMPRISING HYDROPHOBIC DRUG HAVING IMPROVED SOLUBILITY
Document Type and Number:
WIPO Patent Application WO/2005/107719
Kind Code:
A2
Abstract:
A pharmaceutical composition comprising a hydrophobic drug or pharmaceutically acceptable salt thereof and a compound having at least one carboxylic acid moiety, wherein the molar ratio of the compound having at least one carboxylic acid moiety to hydrophobic drug or pharmaceutically acceptable salt thereof is from about 0.1:1 to about 25:1. The pharmaceutical composition exhibits preferably an improved solubility illustrated by rapid dissolution upon contact with physiological solvents, such as water, saliva or gastrointestinal fluids.
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Inventors:
BARBERA GARY (US)
DOSHI CHETAN CHHABILDAS (US)
PATEL MAHENDRA R (US)
DAVILA PABLO (US)
PATEL SATISHKUMAR AMBALAL (US)
DOSHI CHETAN CHHABILDAS (US)
PATEL MAHENDRA R (US)
DAVILA PABLO (US)
PATEL SATISHKUMAR AMBALAL (US)
Application Number:
PCT/EP2005/004885
Publication Date:
November 17, 2005
Filing Date:
May 04, 2005
Export Citation:
Assignee:
SANDOZ AG (CH)
BARBERA GARY (US)
DOSHI CHETAN CHHABILDAS (US)
PATEL MAHENDRA R (US)
DAVILA PABLO (US)
PATEL SATISHKUMAR AMBALAL (US)
BARBERA GARY (US)
DOSHI CHETAN CHHABILDAS (US)
PATEL MAHENDRA R (US)
DAVILA PABLO (US)
PATEL SATISHKUMAR AMBALAL (US)
International Classes:
A61K9/48; A61K31/205; A61K31/496; A61K31/519; A61K31/5513; A61K31/56; A61K31/704; A61K47/12; (IPC1-7): A61K9/48; A61K31/496; A61K47/12; A61P25/18
Domestic Patent References:
| WO1997041896A2 | 1997-11-13 | |||
| WO2004039411A2 | 2004-05-13 | |||
| WO2004039410A2 | 2004-05-13 | |||
| WO1998020873A1 | 1998-05-22 | |||
| WO2000072847A1 | 2000-12-07 |
Foreign References:
| EP0965343A2 | 1999-12-22 | |||
| US4732915A | 1988-03-22 | |||
| EP0439030A2 | 1991-07-31 |
Attorney, Agent or Firm:
Lehmeier, Thomas J. (Corporate Intellectual Property, Basel, CH)
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