Title:
PHARMACEUTICAL COMPOSITION COMPRISING ISOLATED MITOCHONDRIA FOR PREVENTING OR TREATING TENDINOPATHY
Document Type and Number:
WIPO Patent Application WO/2020/091463
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating tendinopathy, comprising isolated mitochondria as an effective component. The pharmaceutical composition of the present invention, comprising isolated mitochondria as an effective component, can restore the ATP synthesis capacity and antioxidant capacity of tenocytes damaged by inflammations to a normal tenocyte level. In addition, the pharmaceutical composition of the present invention, when administered to damaged tenocytes, inhibits the expression of an apoptosis promoter, Bax, and increases the expression of an apoptosis inhibitor, Blc-2. In addition, the pharmaceutical composition of the present invention, when administered to damaged tenocytes, can restore the expression of MMP1 to a normal tenocyte level. Accordingly, the pharmaceutical composition of the present invention may be beneficially used in the prevention or treatment of tendinopathy.
Inventors:
CHOI YONG-SOO (KR)
LEE JI MIN (KR)
KIM MI JIN (KR)
MIN KYUNGHOON (KR)
LEE JI MIN (KR)
KIM MI JIN (KR)
MIN KYUNGHOON (KR)
Application Number:
PCT/KR2019/014605
Publication Date:
May 07, 2020
Filing Date:
October 31, 2019
Export Citation:
Assignee:
UNIV CHA IND ACAD COOP FOUND (KR)
International Classes:
A61K35/12; A61K9/00; A61P19/02; A61P21/00
Domestic Patent References:
| WO2008137035A1 | 2008-11-13 | |||
| WO2017124037A1 | 2017-07-20 |
Foreign References:
| KR20180062387A | 2018-06-08 | |||
| KR20180071030A | 2018-06-27 |
Other References:
LOWES, D. A: "The mitochondria targeted antioxidant MitoQ protects against fluoroquinolone-induced oxidative stress and mitochondrial membrane damage in human Achilles tendon cells", FREE RADICAL RESEARCH, vol. 43, no. 4, 2009, pages 323 - 328, XP055431611
Attorney, Agent or Firm:
FIRSTLAW P.C. (KR)
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