Title:
PHARMACEUTICAL COMPOSITION COMPRISING SALMETEROL AND BUDESONIDE FOR THE TREATMENT OF RESPIRATORY DISORDERS
Document Type and Number:
WIPO Patent Application WO/2003/013547
Kind Code:
A1
Abstract:
Pharmaceutical composition for inhalation, containing as active ingredient effective amounts of salmeterol or a physiologically salt of salmeterol or a solvate thereof, and budesonide or a therapeutically salt of budesonide or a solvate thereof, wherein the molecular ratio of salmeterol component to budesonide component is in the range 1:2 to 1:50, together with a pharmaceutically acceptable carrier.
Inventors:
VANDERBIST FRANCIS (BE)
DEBOECK ARTHUR (US)
BAUDIER PHILIPPE (BE)
DEBOECK ARTHUR (US)
BAUDIER PHILIPPE (BE)
Application Number:
PCT/BE2002/000132
Publication Date:
February 20, 2003
Filing Date:
July 31, 2002
Export Citation:
Assignee:
GALEPHAR M F (BE)
VANDERBIST FRANCIS (BE)
DEBOECK ARTHUR (US)
BAUDIER PHILIPPE (BE)
VANDERBIST FRANCIS (BE)
DEBOECK ARTHUR (US)
BAUDIER PHILIPPE (BE)
International Classes:
A61K9/14; A61L9/04; A61P11/06; B65D21/04; (IPC1-7): A61K31/58; A61P11/06
Other References:
V.MANCINI, L.PINTO: "Fluticasone propionate or budesonide with salmeterol in bronchial severe asthma in pediatric age", ALLERGY, vol. 53, no. suppl.43, 1998, pages 185, XP001013216
N.VAITKIENE E.A.: "Optimal inhaled steroids dose determination for asthma patients using monotherapy or combining it with salmeterol", EUROPEAN RESPIRATORY JOURNAL SUPPLEMENT, vol. 10, no. 25, 1997, pages 105S, XP001013222
J.FERRES E.A.: "Budesonide combined with salmeterolin the treatment of asthma in children", EUROPEAN RESPIRATORY JOURNAL, vol. 12, no. suppl.29, 1998, pages 69s, XP001013401
P.ODEBACK: "Is the addition of salmeterol more effective than doubling the dose of budesonide in mild asthma?", EUROPEAN RESPIRATORY JOURNAL, vol. 12, no. suppl.28, 1998, pages 38s, XP001008684
G.FUGLSANG E.A.: "Effect of salmeterol treatment on nitric oxide level in exhaled air and dose-response to terbutaline in children with mild asthma", PEDIATRIC PULMONOLOGY, vol. 25, no. 5, 1998, pages 314 - 321, XP001073773
D.H.YATES E.A.: "An inhaled glucocorticoid does not prevent tolerance to the bronchoprotective effect of a long-acting inhaled beta2-agonist", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 154, no. 6 part 1, 1996, pages 1603 - 1607, XP001073766
D.H.YATES: "Effect of short- and long-acting inhaled beta2-agonists on exhaled nitric oxide in asthmatic patients", EUROPEAN RESPIRATORY JOURNAL, vol. 10, no. 7, 1997, pages 1483 - 1488, XP001073772
L.P.NIELSEN E.A.: "Salmeterol reduces the need for inhaled corticosteroid in steroid-dependent asthmatics", RESPIRATORY MEDICINE, vol. 93, no. 12, 1999, pages 863 - 868, XP001073799
N.VAITKIENE E.A.: "Optimal inhaled steroids dose determination for asthma patients using monotherapy or combining it with salmeterol", EUROPEAN RESPIRATORY JOURNAL SUPPLEMENT, vol. 10, no. 25, 1997, pages 105S, XP001013222
J.FERRES E.A.: "Budesonide combined with salmeterolin the treatment of asthma in children", EUROPEAN RESPIRATORY JOURNAL, vol. 12, no. suppl.29, 1998, pages 69s, XP001013401
P.ODEBACK: "Is the addition of salmeterol more effective than doubling the dose of budesonide in mild asthma?", EUROPEAN RESPIRATORY JOURNAL, vol. 12, no. suppl.28, 1998, pages 38s, XP001008684
G.FUGLSANG E.A.: "Effect of salmeterol treatment on nitric oxide level in exhaled air and dose-response to terbutaline in children with mild asthma", PEDIATRIC PULMONOLOGY, vol. 25, no. 5, 1998, pages 314 - 321, XP001073773
D.H.YATES E.A.: "An inhaled glucocorticoid does not prevent tolerance to the bronchoprotective effect of a long-acting inhaled beta2-agonist", AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, vol. 154, no. 6 part 1, 1996, pages 1603 - 1607, XP001073766
D.H.YATES: "Effect of short- and long-acting inhaled beta2-agonists on exhaled nitric oxide in asthmatic patients", EUROPEAN RESPIRATORY JOURNAL, vol. 10, no. 7, 1997, pages 1483 - 1488, XP001073772
L.P.NIELSEN E.A.: "Salmeterol reduces the need for inhaled corticosteroid in steroid-dependent asthmatics", RESPIRATORY MEDICINE, vol. 93, no. 12, 1999, pages 863 - 868, XP001073799
Attorney, Agent or Firm:
Powis De, Tenbossche Roland (Boulevard Lambermont 140, Bruxelles, BE)
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