Title:
PHARMACEUTICAL COMPOSITION FOR CONFORMATIONAL DISEASE
Document Type and Number:
WIPO Patent Application WO/2007/123187
Kind Code:
A1
Abstract:
Disclosed is a pharmaceutical composition having a prophylactic or therapeutic effect
on a conformational disease such as Alzheimer's disease, prion disease
and amyloidosis. The pharmaceutical composition comprises, as an active ingredient,
at least one cellulose ether selected from a cellulose ether having a constitutional
unit represented by the general formula (1) shown below, an alkali metal salt
of the cellulose ether, an aliphatic acid ester of the cellulose ether, and a mixture
thereof. (1) wherein at least one of R's is selected from CH3,
C2H5, CH2CH2OH, CH2CH(OH)CH3
and CH2COOM, and the others are independently represent H; and M is
selected from H, Na, K and Ca.
Inventors:
DOHURA KATSUMI (JP)
Application Number:
PCT/JP2007/058566
Publication Date:
November 01, 2007
Filing Date:
April 20, 2007
Export Citation:
Assignee:
ITOHAM FOODS INC (JP)
UNIV TOHOKU NAT UNIV CORP (JP)
DOHURA KATSUMI (JP)
UNIV TOHOKU NAT UNIV CORP (JP)
DOHURA KATSUMI (JP)
International Classes:
C08B11/08; A61K31/717; A61P25/28; C08B11/02
Domestic Patent References:
| WO2006090815A1 | 2006-08-31 | |||
| WO2003051387A1 | 2003-06-26 | |||
| WO2004048401A1 | 2004-06-10 |
Foreign References:
| JP2003040778A | 2003-02-13 | |||
| JP2003267874A | 2003-09-25 | |||
| JP2001513569A | 2001-09-04 | |||
| JP2005192415A | 2005-07-21 | |||
| JP2004099553A | 2004-04-02 | |||
| JP2005350391A | 2005-12-22 | |||
| JP2005104850A | 2005-04-21 | |||
| JP2001513569A | 2001-09-04 | |||
| JP2001172171A | 2001-06-26 | |||
| JP2001275687A | 2001-10-09 |
Other References:
ROBIN W CARRELL; DAVID A LOMAS, THE LANCET, vol. 350, 1997, pages 134 - 138
"Basic Study and Clinical Application of Amyloidosis", March 2005, KANEHARA & CO., LTD., pages: 8 - 13
TAKESHI IWATSUBO, CELL TECHNOLOGY, vol. 20, no. 11, 2001, pages 1474 - 1477
JARRETT JT; LANSBURY PT JR., CELL, vol. 73, 1993, pages 1055 - 1058
GERVAIS F; MORISSETTE C; KONG X, CURR. MED. CHEM. IMMUN., ENDOC. & METAB. AGENTS, vol. 3, 2003, pages 361 - 370
WATSON JD; LANDER DA; SELKOE JD, THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 50, 1997, pages 31617 - 31624
KISILEVSKY R, NATURE MEDICINE, vol. 1, 1995, pages 143 - 148
ZHU H; YU J; KINDY MS, MOLECULAR MEDICINE, vol. 7, 2001, pages 517 - 522
K4TSUMI DOURA, PHARMACIA, vol. 7, 2002, pages 635 - 639
K. ISHIKAWA; K: DOH-URA ET AL., JOURNAL OF GENERAL VIROLOGY, vol. 85, 2004, pages 1785 - 1790
KATSUMI DOH-URA ET AL., JOURNAL OF VIROLOGY, vol. 78, 2004, pages 4999 - 5006
"Brain Experiment Manual Viewed in Mouse Color Atlas and Photograph", 2005, YODOSHA CO., LTD., pages: 52
"Special Experimental Zoology", 1972, ASAKURA PUBLISHING CO., LTD., pages: 12
GERLOWSKI LE; JAIN RK, JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 72, no. 10, 1983, pages 1103 - 1127
NAIKI H; NAKAKUKI K., LABORATORY INVESTIGATION, vol. 74, no. 2, 1996, pages 374 - 383
HIROSHI HATANAKA; HIROKO TSUKUI: "Culture of nerve cells from several central nerve nuclei", EXPERIMENTAL MEDICINE, EXTRA NUMBER: MANUAL FOR NEUROBIOCHEMISTRY, 1990, pages 129 - 135
D. BOCHE; C. CUNNINGHAM ET AL., NEUROBIOLOGY OF DISEASE, vol. 22, 2006, pages 638 - 650
"Basic Study and Clinical Application of Amyloidosis", March 2005, KANEHARA & CO., LTD., pages: 8 - 13
TAKESHI IWATSUBO, CELL TECHNOLOGY, vol. 20, no. 11, 2001, pages 1474 - 1477
JARRETT JT; LANSBURY PT JR., CELL, vol. 73, 1993, pages 1055 - 1058
GERVAIS F; MORISSETTE C; KONG X, CURR. MED. CHEM. IMMUN., ENDOC. & METAB. AGENTS, vol. 3, 2003, pages 361 - 370
WATSON JD; LANDER DA; SELKOE JD, THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 50, 1997, pages 31617 - 31624
KISILEVSKY R, NATURE MEDICINE, vol. 1, 1995, pages 143 - 148
ZHU H; YU J; KINDY MS, MOLECULAR MEDICINE, vol. 7, 2001, pages 517 - 522
K4TSUMI DOURA, PHARMACIA, vol. 7, 2002, pages 635 - 639
K. ISHIKAWA; K: DOH-URA ET AL., JOURNAL OF GENERAL VIROLOGY, vol. 85, 2004, pages 1785 - 1790
KATSUMI DOH-URA ET AL., JOURNAL OF VIROLOGY, vol. 78, 2004, pages 4999 - 5006
"Brain Experiment Manual Viewed in Mouse Color Atlas and Photograph", 2005, YODOSHA CO., LTD., pages: 52
"Special Experimental Zoology", 1972, ASAKURA PUBLISHING CO., LTD., pages: 12
GERLOWSKI LE; JAIN RK, JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 72, no. 10, 1983, pages 1103 - 1127
NAIKI H; NAKAKUKI K., LABORATORY INVESTIGATION, vol. 74, no. 2, 1996, pages 374 - 383
HIROSHI HATANAKA; HIROKO TSUKUI: "Culture of nerve cells from several central nerve nuclei", EXPERIMENTAL MEDICINE, EXTRA NUMBER: MANUAL FOR NEUROBIOCHEMISTRY, 1990, pages 129 - 135
D. BOCHE; C. CUNNINGHAM ET AL., NEUROBIOLOGY OF DISEASE, vol. 22, 2006, pages 638 - 650
Attorney, Agent or Firm:
Kyosei International Patent Office (8-14 Akasaka 3-chom, Minato-ku Tokyo 52, JP)
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