Title:
PHARMACEUTICAL COMPOSITION CONTAINING 2,4-DIAMINOQUINAZOLINE DERIVATIVE OR SALT THEREOF AS ACTIVE INGREDIENT, AND 2,4-DIAMINOQUINAZOLINE DERIVATIVE HAVING SPECIFIC STRUCTURE
Document Type and Number:
WIPO Patent Application WO/2017/150174
Kind Code:
A1
Abstract:
Provided is a pharmaceutical composition for the treatment or prevention of Plasmodium diseases, the pharmaceutical composition being characterized by containing at least one quinazoline derivative represented by general formula (I) or a salt thereof.
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Inventors:
MIZUKAWA YUKI (JP)
ITOH ISAMU (JP)
IHARA MASATAKA (JP)
SAKANOUE SEIKI (JP)
ITOH ISAMU (JP)
IHARA MASATAKA (JP)
SAKANOUE SEIKI (JP)
Application Number:
PCT/JP2017/005318
Publication Date:
September 08, 2017
Filing Date:
February 14, 2017
Export Citation:
Assignee:
SYNSTAR JAPAN CO LTD (JP)
International Classes:
A61K31/517; A61P33/06
Domestic Patent References:
| WO2004062666A2 | 2004-07-29 |
Foreign References:
| US2497347A | 1950-02-14 | |||
| JPH11209287A | 1999-08-03 | |||
| JP2009545544A | 2009-12-24 | |||
| GB587936A | 1947-05-09 | |||
| KR20140000531A | 2014-01-03 | |||
| EP2433636A1 | 2012-03-28 | |||
| JP2004528314A | 2004-09-16 |
Other References:
CURD. F. H. S. ET AL.: "Synthetic Antimalarials. Part XXXI. 2-p-Chloroanilino-4-beta-di- ethylaminoethylaminoquinazolines containing Various Substituents in the Quinazoline Nucleus.", JOURNAL OF THE CHEMICAL SOCIETY, 1948, pages 1759 - 66, XP009064869
FRANCISCO-JAVIER GAMO ET AL.: "Thousands of chemical starting points for antimalarial lead identification", NATURE, vol. 465, no. 20, 2010, pages 305 - 312, XP002600760
ANQI MA ET AL.: "Structure-activity relationship studies of SETD8 inhibitors", MEDCHEMCOMM, vol. 5, 2014, pages 1892 - 1898, XP055414573
TUAN-ANH N. PHAM ET AL.: "Synthesis and biological evaluation of novel 2,4- disubstituted quinazoline analogues as GPR119 agonists", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, 2013, pages 1349 - 1356, XP028977149
K. YOKOYAMA ET AL.: "Discovery of potent CCR4 antagonists: Synthesis and structure-activity relationship study of 2,4-diaminoquinazolines", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, 2008, pages 7021 - 7032, XP022941570
SANDEEP SUNDRIYAL ET AL.: "Development of Diaminoquinazoline Histone Lysine Methyltransferase Inhibitors as Potent Blood- Stage Antimalarial Compounds", CHEMMEDCHEM, vol. 9, no. 10, 2014, pages 2360 - 2373, XP055414575
TANTRY, SUBRAMANYAM J. ET AL.: "Scaffold morphing leading to evolution of 2,4- diaminoquinolines and aminopyrazolopyrimidines as inhibitors of the ATP synthesis pathway", MEDCHEMCOMM, vol. 7, no. 5, 1 May 2016 (2016-05-01), pages 1022 - 1032, XP055414576
FRANCISCO-JAVIER GAMO ET AL.: "Thousands of chemical starting points for antimalarial lead identification", NATURE, vol. 465, no. 20, 2010, pages 305 - 312, XP002600760
ANQI MA ET AL.: "Structure-activity relationship studies of SETD8 inhibitors", MEDCHEMCOMM, vol. 5, 2014, pages 1892 - 1898, XP055414573
TUAN-ANH N. PHAM ET AL.: "Synthesis and biological evaluation of novel 2,4- disubstituted quinazoline analogues as GPR119 agonists", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 21, 2013, pages 1349 - 1356, XP028977149
K. YOKOYAMA ET AL.: "Discovery of potent CCR4 antagonists: Synthesis and structure-activity relationship study of 2,4-diaminoquinazolines", BIOORGANIC & MEDICINAL CHEMISTRY, vol. 16, 2008, pages 7021 - 7032, XP022941570
SANDEEP SUNDRIYAL ET AL.: "Development of Diaminoquinazoline Histone Lysine Methyltransferase Inhibitors as Potent Blood- Stage Antimalarial Compounds", CHEMMEDCHEM, vol. 9, no. 10, 2014, pages 2360 - 2373, XP055414575
TANTRY, SUBRAMANYAM J. ET AL.: "Scaffold morphing leading to evolution of 2,4- diaminoquinolines and aminopyrazolopyrimidines as inhibitors of the ATP synthesis pathway", MEDCHEMCOMM, vol. 7, no. 5, 1 May 2016 (2016-05-01), pages 1022 - 1032, XP055414576
Attorney, Agent or Firm:
TAIYO, NAKAJIMA & KATO (JP)
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