Title:
PHARMACEUTICAL COMPOSITION CONTAINING ACID ADDITION SALT OF N,N-DIMETHYL IMIDOCARBONIMIDIC DIAMIDE FOR ANTI-CANCER
Document Type and Number:
WIPO Patent Application WO/2011/049400
Kind Code:
A2
Abstract:
Provided is a use for anticancer of dichloroacetic acid salt or aminooxyacetic acid salt of N,N-dimethyl imidodicarbonimidic diamide (metformin). According to the present invention, the acid addition salt of metformin synergistically causes anticancer effect by AMPK enzyme activation of metformin and anticancer effect of organic acids used as a salt, and thus shows a remarkable anticancer effect. In addition, the acid addition salt has superior physiochemical properties such as solubility, stability, non-hygroscopicity, processibility as a tablet formulation and the like, and has lower toxicity compared with metformin hydrochloride. Therefore, the acid addition salt can be useful as a pharmaceutically acceptable salt.
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Inventors:
KIM SUNG WUK (KR)
JUN SUNG SOO (KR)
KIM YOUNG WOONG (KR)
OH BYUNG KYU (KR)
LEE SEUNG HO (KR)
JUN SUNG SOO (KR)
KIM YOUNG WOONG (KR)
OH BYUNG KYU (KR)
LEE SEUNG HO (KR)
Application Number:
PCT/KR2010/007273
Publication Date:
April 28, 2011
Filing Date:
October 22, 2010
Export Citation:
Assignee:
HANALL BIOPHARMA CO LTD (KR)
KIM SUNG WUK (KR)
JUN SUNG SOO (KR)
KIM YOUNG WOONG (KR)
OH BYUNG KYU (KR)
LEE SEUNG HO (KR)
KIM SUNG WUK (KR)
JUN SUNG SOO (KR)
KIM YOUNG WOONG (KR)
OH BYUNG KYU (KR)
LEE SEUNG HO (KR)
International Classes:
A61K31/155; A61P3/04; A61P3/06; A61P3/10
Foreign References:
| US4028402A | 1977-06-07 | |||
| KR20080071095A | 2008-08-01 | |||
| US4835184A | 1989-05-30 | |||
| US3957853A | 1976-05-18 | |||
| US4080472A | 1978-03-21 | |||
| US6031004A | 2000-02-29 |
Attorney, Agent or Firm:
DANA PATENT LAW FIRM (KR)
특허법인다나 (KR)
특허법인다나 (KR)
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