Title:
PHARMACEUTICAL COMPOSITION CONTAINING ANTAGONIST OF EGF FAMILY LIGAND AS COMPONENT
Document Type and Number:
WIPO Patent Application WO/2010/137654
Kind Code:
A1
Abstract:
A combination of targets for the EGFR ligand inhibition for the purpose of inhibiting the proliferation of cancer cells can be identified. More specifically, it is found that an EREG antagonist and a TGFα antagonist are useful as cell proliferation inhibitors. Thus, disclosed is a pharmaceutical composition containing an antagonist of an EGF family ligand as a component.
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Inventors:
YOSHIDA KENJI (JP)
ITO HIROTAKA (JP)
ITO HIROTAKA (JP)
Application Number:
PCT/JP2010/059008
Publication Date:
December 02, 2010
Filing Date:
May 27, 2010
Export Citation:
Assignee:
FORERUNNER PHARMA RES CO LTD (JP)
YOSHIDA KENJI (JP)
ITO HIROTAKA (JP)
YOSHIDA KENJI (JP)
ITO HIROTAKA (JP)
International Classes:
A61K45/06; A61K39/395; A61P35/00; A61P43/00; C07K16/24; C07K16/46; G01N33/15; G01N33/50; C12N15/09
Domestic Patent References:
| WO2008047723A1 | 2008-04-24 | |||
| WO2007015578A1 | 2007-02-08 | |||
| WO2008047723A1 | 2008-04-24 | |||
| WO2004076622A2 | 2004-09-10 | |||
| WO2003104453A1 | 2003-12-18 | |||
| WO1994025585A1 | 1994-11-10 | |||
| WO1993012227A1 | 1993-06-24 | |||
| WO1992003918A1 | 1992-03-19 | |||
| WO1994002602A1 | 1994-02-03 | |||
| WO1994011523A2 | 1994-05-26 | |||
| WO1996002576A1 | 1996-02-01 | |||
| WO1996034096A1 | 1996-10-31 | |||
| WO1996033735A1 | 1996-10-31 | |||
| WO1992001047A1 | 1992-01-23 | |||
| WO1992020791A1 | 1992-11-26 | |||
| WO1993006213A1 | 1993-04-01 | |||
| WO1993011236A1 | 1993-06-10 | |||
| WO1993019172A1 | 1993-09-30 | |||
| WO1995001438A1 | 1995-01-12 | |||
| WO1995015388A1 | 1995-06-08 | |||
| WO1993011161A1 | 1993-06-10 | |||
| WO1999054342A1 | 1999-10-28 | |||
| WO2000061739A1 | 2000-10-19 | |||
| WO2002031140A1 | 2002-04-18 | |||
| WO2002079255A1 | 2002-10-10 | |||
| WO2008047914A1 | 2008-04-24 |
Foreign References:
| JP2008527978A | 2008-07-31 | |||
| JPH0159878B2 | 1989-12-20 | |||
| EP0239400A2 | 1987-09-30 | |||
| EP0404097A2 | 1990-12-27 |
Other References:
DEAN C ET AL.: "Immunotherapy with antibodies to the EGF receptor", INTERNATIONAL JOURNAL OF CANCER, vol. 57, no. SUPPL., 1994, pages 103 - 107, XP008150875
MODJTAHEDI H ET AL.: "Anti-EGFR monoclonal antibodies which act as EGF, TGFa, HB-EGF and BTC antagonists block the binding of epiregulin to EGFR-expressing tumours", INTERNATIONAL JOURNAL OF CANCER, vol. 75, no. 2, 1998, pages 310 - 316, XP002492891
ITO M ET AL.: "Expression of several growth factors and their receptor genes in human colon carcinomas", VIRCHOWS ARCHIV. B, CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY, vol. 59, no. 3, 1990, pages 173 - 178, XP009015191
QIAN JF ET AL.: "Human transforming growth factor alpha: sequence analysis of the 4.5-kb and 1.6-kb mRNA species", GENE, vol. 132, no. 2, 1993, pages 291 - 296, XP023541751
LU Y ET AL.: "Immunogene Therapy of Tumors with Vaccine Based on Xenogeneic Epidermal Growth Factor Receptor", THE JOURNAL OF IMMUNOLOGY, vol. 170, no. 6, 2003, pages 3162 - 3170, XP002384263
See also references of EP 2436397A4
BABA, I. ET AL., CANCER RES., vol. 60, 2000, pages 6886 - 6889
FORCE, T. ET AL., NAT. REV. CANCER, vol. 7, 2007, pages 332 - 344
HIGASHIYAMA, S. ET AL., CANCER SCI., vol. 99, 2008, pages 214 - 220
JOHNSON, G. R. ET AL., J. CELL BIOL., vol. 118, 1992, pages 741 - 751
LACOUTURE, M. E., NAT. REV. CANCER, vol. 6, 2006, pages 803 - 812
SCHNEIDER, M. R.; WOLF, E., J. CELL. PHYSIOL., vol. 218, 2009, pages 460 - 466
SETH, D. ET AL., BR. J. CANCER, vol. 80, 1999, pages 657 - 669
TEJPAR, S. ET AL., LANCET ONCOL., vol. 8, 2007, pages 387 - 394
GROENESTEGE, W. M. ET AL., J. CLIN. INVEST., vol. 117, 2007, pages 2260 - 2267
WILLMARTH, N. E. ET AL., J. BIOL. CHEM., vol. 281, 2006, pages 37728 - 37737
WILSON, K.J. ET AL., PHARMACOL. THER., vol. 122, 2009, pages 1 - 8
SAMBROOK, J. ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOR LAB. PRESS, pages: 9.47 - 9.58
J. IMMUNOL., vol. 123, 1979, pages 1548 - 1550
CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 81, 1978, pages 1 - 7
KOHLER. G.; MILSTEIN, C., EUR. J. IMMUNOL., vol. 6, 1976, pages 511 - 519
MARGULIES. D.H., CELL, vol. 8, 1976, pages 405 - 415
SHULMAN, M. ET AL., NATURE, vol. 276, 1978, pages 269 - 270
DE ST. GROTH, S. F., J. IMMUNOL. METHODS, vol. 35, 1980, pages 1 - 21
TROWBRIDGE, 1. S., J. EXP. MED., vol. 148, 1978, pages 313 - 323
GALFRE, G., NATURE, vol. 277, 1979, pages 131 - 133
KOHLER. G.; MILSTEIN, C., METHODS ENZYMOL., vol. 73, 1981, pages 3 - 46
VANDAMME, A. M. ET AL., EUR. J. BIOCHEM., vol. 192, 1990, pages 767 - 775
CHIRGWIN, J. M. ET AL., BIOCHEMISTRY, vol. 18, 1979, pages 5294 - 5299
CHOMCZYNSKI, P. ET AL., ANAL. BIOCHEM., vol. 162, 1987, pages 156 - 159
FROHMAN, M. A. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 8998 - 9002
BELYAVSKY, A., NUCLEIC ACIDS RES., vol. 17, 1989, pages 2919 - 2932
EBERT, K. M. ET AL., BIO/TECHNOLOGY, vol. 12, 1994, pages 699 - 702
SATO, K. ET AL., CANCER RES., vol. 53, 1993, pages 851 - 856
CO, M. S. ET AL., J. IMMUNOL., vol. 152, 1994, pages 2968 - 2976
BETTER, M.; HORWITZ, A. H., METHODS IN ENZYMOLOGY, vol. 178, 1989, pages 476 - 496
PLUECKTHUN, A.; SKERRA, A., METHODS IN ENZYMOLOGY, vol. 178, 1989, pages 476 - 496
LAMOYI, E., METHODS IN ENZYMOLOGY, vol. 121, 1989, pages 652 - 663
ROUSSEAUX, J. ET AL., METHODS IN ENZYMOLOGY, vol. 121, 1989, pages 663 - 669
BIRD, R. E. ET AL., TIBTECH, vol. 9, 1991, pages 132 - 137
HOLLINGER P. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
HUSTON, J. S. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 85, 1988, pages 5879 - 5883
HUDSON ET AL., J. HNMUNOL. METHODS, vol. 231, 1999, pages 177 - 189
PROTEIN ENGINEERING, vol. 9, no. 3, 1996, pages 299 - 305
CO, M. S., J. IMMUNOL., vol. 152, 1994, pages 2968 - 2976
BETTER, M.; HORWITZ, A. H., METHODS ENZYMOL., vol. 178, 1989, pages 476 - 496
PLUCKTHUN, A.; SKERRA, A., METHODS ENZYMOL., vol. 178, 1989, pages 497 - 515
LAMOYI, E., METHODS ENZYMOL., vol. 121, 1986, pages 652 - 663
ROUSSEAUX, J. ET AL., METHODS ENZYMOL., vol. 121, 1986, pages 663 - 669
BIRD, R. E.; WALKER, B. W., TRENDS BIOTECHNOL., vol. 9, 1991, pages 132 - 137
MULLIGAN ET AL., NATURE, vol. 277, 1979, pages 108
MIZUSHIMA ET AL., NUCLEIC ACIDS RES., vol. 18, 1990, pages 5322
WARD, NATURE, vol. 341, 1989, pages 544 - 546
FASEB J., vol. 6, 1992, pages 2422 - 2427
BETTER ET AL., SCIENCE, vol. 240, 1988, pages 1041 - 1043
LEI, S. P. ET AL., J. BACTERIOL., vol. 169, 1987, pages 4379
"Antibodies A Laboratory Manual.", 1988, COLD SPRING HARBOR LABORATORY
"Immunologic studies in humans", 1993, JOHN WILEY & SONS, INC., article "Current Protocols in Immunology"
WILBUR, W. J.; LIPMAN, D. J., PROC. NATL. ACAD. SCI. USA, vol. 80, 1983, pages 726 - 730
"Remington's Pharmaceutical Science", MARK PUBLISHING COMPANY
CIARDIELLO ET AL., CLIN CANCER RES, vol. 5, 1999, pages 909 - 916
MODJTAHEDI H ET AL.: "Anti-EGFR monoclonal antibodies which act as EGF, TGFa, HB-EGF and BTC antagonists block the binding of epiregulin to EGFR-expressing tumours", INTERNATIONAL JOURNAL OF CANCER, vol. 75, no. 2, 1998, pages 310 - 316, XP002492891
ITO M ET AL.: "Expression of several growth factors and their receptor genes in human colon carcinomas", VIRCHOWS ARCHIV. B, CELL PATHOLOGY INCLUDING MOLECULAR PATHOLOGY, vol. 59, no. 3, 1990, pages 173 - 178, XP009015191
QIAN JF ET AL.: "Human transforming growth factor alpha: sequence analysis of the 4.5-kb and 1.6-kb mRNA species", GENE, vol. 132, no. 2, 1993, pages 291 - 296, XP023541751
LU Y ET AL.: "Immunogene Therapy of Tumors with Vaccine Based on Xenogeneic Epidermal Growth Factor Receptor", THE JOURNAL OF IMMUNOLOGY, vol. 170, no. 6, 2003, pages 3162 - 3170, XP002384263
See also references of EP 2436397A4
BABA, I. ET AL., CANCER RES., vol. 60, 2000, pages 6886 - 6889
FORCE, T. ET AL., NAT. REV. CANCER, vol. 7, 2007, pages 332 - 344
HIGASHIYAMA, S. ET AL., CANCER SCI., vol. 99, 2008, pages 214 - 220
JOHNSON, G. R. ET AL., J. CELL BIOL., vol. 118, 1992, pages 741 - 751
LACOUTURE, M. E., NAT. REV. CANCER, vol. 6, 2006, pages 803 - 812
SCHNEIDER, M. R.; WOLF, E., J. CELL. PHYSIOL., vol. 218, 2009, pages 460 - 466
SETH, D. ET AL., BR. J. CANCER, vol. 80, 1999, pages 657 - 669
TEJPAR, S. ET AL., LANCET ONCOL., vol. 8, 2007, pages 387 - 394
GROENESTEGE, W. M. ET AL., J. CLIN. INVEST., vol. 117, 2007, pages 2260 - 2267
WILLMARTH, N. E. ET AL., J. BIOL. CHEM., vol. 281, 2006, pages 37728 - 37737
WILSON, K.J. ET AL., PHARMACOL. THER., vol. 122, 2009, pages 1 - 8
SAMBROOK, J. ET AL.: "Molecular Cloning", 1989, COLD SPRING HARBOR LAB. PRESS, pages: 9.47 - 9.58
J. IMMUNOL., vol. 123, 1979, pages 1548 - 1550
CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY, vol. 81, 1978, pages 1 - 7
KOHLER. G.; MILSTEIN, C., EUR. J. IMMUNOL., vol. 6, 1976, pages 511 - 519
MARGULIES. D.H., CELL, vol. 8, 1976, pages 405 - 415
SHULMAN, M. ET AL., NATURE, vol. 276, 1978, pages 269 - 270
DE ST. GROTH, S. F., J. IMMUNOL. METHODS, vol. 35, 1980, pages 1 - 21
TROWBRIDGE, 1. S., J. EXP. MED., vol. 148, 1978, pages 313 - 323
GALFRE, G., NATURE, vol. 277, 1979, pages 131 - 133
KOHLER. G.; MILSTEIN, C., METHODS ENZYMOL., vol. 73, 1981, pages 3 - 46
VANDAMME, A. M. ET AL., EUR. J. BIOCHEM., vol. 192, 1990, pages 767 - 775
CHIRGWIN, J. M. ET AL., BIOCHEMISTRY, vol. 18, 1979, pages 5294 - 5299
CHOMCZYNSKI, P. ET AL., ANAL. BIOCHEM., vol. 162, 1987, pages 156 - 159
FROHMAN, M. A. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 85, 1988, pages 8998 - 9002
BELYAVSKY, A., NUCLEIC ACIDS RES., vol. 17, 1989, pages 2919 - 2932
EBERT, K. M. ET AL., BIO/TECHNOLOGY, vol. 12, 1994, pages 699 - 702
SATO, K. ET AL., CANCER RES., vol. 53, 1993, pages 851 - 856
CO, M. S. ET AL., J. IMMUNOL., vol. 152, 1994, pages 2968 - 2976
BETTER, M.; HORWITZ, A. H., METHODS IN ENZYMOLOGY, vol. 178, 1989, pages 476 - 496
PLUECKTHUN, A.; SKERRA, A., METHODS IN ENZYMOLOGY, vol. 178, 1989, pages 476 - 496
LAMOYI, E., METHODS IN ENZYMOLOGY, vol. 121, 1989, pages 652 - 663
ROUSSEAUX, J. ET AL., METHODS IN ENZYMOLOGY, vol. 121, 1989, pages 663 - 669
BIRD, R. E. ET AL., TIBTECH, vol. 9, 1991, pages 132 - 137
HOLLINGER P. ET AL., PROC. NATL. ACAD. SCI. USA, vol. 90, 1993, pages 6444 - 6448
HUSTON, J. S. ET AL., PROC. NATL. ACAD. SCI. U.S.A., vol. 85, 1988, pages 5879 - 5883
HUDSON ET AL., J. HNMUNOL. METHODS, vol. 231, 1999, pages 177 - 189
PROTEIN ENGINEERING, vol. 9, no. 3, 1996, pages 299 - 305
CO, M. S., J. IMMUNOL., vol. 152, 1994, pages 2968 - 2976
BETTER, M.; HORWITZ, A. H., METHODS ENZYMOL., vol. 178, 1989, pages 476 - 496
PLUCKTHUN, A.; SKERRA, A., METHODS ENZYMOL., vol. 178, 1989, pages 497 - 515
LAMOYI, E., METHODS ENZYMOL., vol. 121, 1986, pages 652 - 663
ROUSSEAUX, J. ET AL., METHODS ENZYMOL., vol. 121, 1986, pages 663 - 669
BIRD, R. E.; WALKER, B. W., TRENDS BIOTECHNOL., vol. 9, 1991, pages 132 - 137
MULLIGAN ET AL., NATURE, vol. 277, 1979, pages 108
MIZUSHIMA ET AL., NUCLEIC ACIDS RES., vol. 18, 1990, pages 5322
WARD, NATURE, vol. 341, 1989, pages 544 - 546
FASEB J., vol. 6, 1992, pages 2422 - 2427
BETTER ET AL., SCIENCE, vol. 240, 1988, pages 1041 - 1043
LEI, S. P. ET AL., J. BACTERIOL., vol. 169, 1987, pages 4379
"Antibodies A Laboratory Manual.", 1988, COLD SPRING HARBOR LABORATORY
"Immunologic studies in humans", 1993, JOHN WILEY & SONS, INC., article "Current Protocols in Immunology"
WILBUR, W. J.; LIPMAN, D. J., PROC. NATL. ACAD. SCI. USA, vol. 80, 1983, pages 726 - 730
"Remington's Pharmaceutical Science", MARK PUBLISHING COMPANY
CIARDIELLO ET AL., CLIN CANCER RES, vol. 5, 1999, pages 909 - 916
Attorney, Agent or Firm:
SHIMIZU, Hatsushi et al. (JP)
Spring water Original aim (JP)
Spring water Original aim (JP)
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