Title:
PHARMACEUTICAL COMPOSITION CONTAINING BENZIMIDAZOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2024/029819
Kind Code:
A1
Abstract:
The present invention relates to a benzimidazole derivative or a pharmaceutically acceptable salt thereof, and a preparation method thereof. The benzimidazole derivative or pharmaceutically acceptable salt thereof exhibit the effect of strongly inhibiting the production of PGE2, which is an inflammatory mediator, in A549 (a human lung cancer cell line) through the inhibitory activity of microsomal prostaglandin E2 synthase-1 (mPGES-1), and can be used as a pharmaceutical composition for treating mPGES-1-mediated diseases.
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Inventors:
LEE JAE YEOL (KR)
LEE KYUNG-TAE (KR)
KIM JAEMIN (KR)
YOON YOUNGSEO (KR)
YANG SEYOUNG (KR)
MOON GWANG HYUN (KR)
AHN JUNSEONG (KR)
GWON MINJU (KR)
CHOI HYEMIN (KR)
KIM MINJI (KR)
WOO JIWON (KR)
LEE KYUNG-TAE (KR)
KIM JAEMIN (KR)
YOON YOUNGSEO (KR)
YANG SEYOUNG (KR)
MOON GWANG HYUN (KR)
AHN JUNSEONG (KR)
GWON MINJU (KR)
CHOI HYEMIN (KR)
KIM MINJI (KR)
WOO JIWON (KR)
Application Number:
PCT/KR2023/010808
Publication Date:
February 08, 2024
Filing Date:
July 26, 2023
Export Citation:
Assignee:
UNIV INDUSTRY COOPERATION GROUP KYUNG HEE UNIV (KR)
International Classes:
C07D235/18; A23L33/10; A61K31/4184; A61P29/00
Domestic Patent References:
| WO2011099832A2 | 2011-08-18 | |||
| WO2012076672A1 | 2012-06-14 | |||
| WO2012055995A1 | 2012-05-03 |
Foreign References:
| US20070004713A1 | 2007-01-04 |
Other References:
UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY: "Development of a New PGE2 Production Inhibitor Based on Benzimidazole", INDUSTRY-ACADEMIA JOINT TECHNOLOGY DEVELOPMENT PROJECT REPORT, January 2022 (2022-01-01), pages 1 - 32
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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