Title:
PHARMACEUTICAL COMPOSITION CONTAINING HERES EXPRESSION INHIBITOR FOR PREVENTING OR TREATING SQUAMOUS CELL CARCINOMAMODULATOR
Document Type and Number:
WIPO Patent Application WO/2020/246717
Kind Code:
A1
Abstract:
The present invention pertains to a pharmaceutical composition for preventing or treating squamous cell carcinoma, the pharmaceutical composition containing a HERES (Highly Expressed lncRNAs in Esophageal Squamous Cell Carcinoma) expression inhibitor. More specifically, the present invention pertains to a pharmaceutical composition which uses a HERES expression inhibitor to reduce the expression of HERES and affect Wnt signaling pathways, and thereby prevent or treat squamous cell carcinoma. The present inventors discovered that the expression pattern of HERES is related to the onset of squamous cell carcinoma, and found that HERES can be a target for treating squamous cell carcinoma. Accordingly, the pharmaceutical composition according to the present invention was determined to have the effect of inhibiting the proliferation, metastasis, etc. of squamous cell carcinoma due to containing the HERES expression inhibitor, and is thus expected to be advantageously used for preventing and treating or ameliorating squamous cell carcinoma.
Inventors:
NAM JIN-WU (KR)
YOU BO-HYUN (KR)
LEE SANG KIL (KR)
YOON JUNG HO (KR)
YOU BO-HYUN (KR)
LEE SANG KIL (KR)
YOON JUNG HO (KR)
Application Number:
PCT/KR2020/006064
Publication Date:
December 10, 2020
Filing Date:
May 08, 2020
Export Citation:
Assignee:
UNIV HANYANG IND UNIV COOP FOUND (KR)
UNIV YONSEI IACF (KR)
UNIV YONSEI IACF (KR)
International Classes:
A61K31/7088; A61K48/00; A61P35/00
Foreign References:
| US20180112272A1 | 2018-04-26 | |||
| US20160271163A1 | 2016-09-22 |
Other References:
LUMING WANG, MENG DI, WANG YIQING, HU JIAN: "Long non-coding RNA LINC01296 promotes esophageal squamous cell carcinoma cell proliferation and invasion by epigenetic suppression of KLF2", AMERICAN JOURNAL OF CANCER RESEARCH, vol. 8, no. 10, 1 October 2018 (2018-10-01), pages 2020 - 2029, XP055771719
YU JUN, WU XIAOLIU, HUANG KAIDAN, ZHU MING, ZHANG XIAOMEI, ZHANG YUANYING, CHEN SENQING, XU XINYU, ZHANG QIN: "Bioinformatics identification of IncRNA biomarkers associated with the progression of esophageal squamous cell carcinoma", MOLECULAR MEDICINE REPORTS, vol. 19, no. 6, 2 May 2019 (2019-05-02) - June 2019 (2019-06-01), pages 5309 - 5320, XP055771723
DATABASE NUCLEOTIDE 16 April 2005 (2005-04-16), "Homo sapiens BAC clone RP11-284E5 from 2, complete sequence", XP055771728, retrieved from NCBI Database accession no. AC006460.4
SHEN ET AL., J CANCER., vol. 7, no. 10, 2016, pages 1258 - 1264
YU JUN, WU XIAOLIU, HUANG KAIDAN, ZHU MING, ZHANG XIAOMEI, ZHANG YUANYING, CHEN SENQING, XU XINYU, ZHANG QIN: "Bioinformatics identification of IncRNA biomarkers associated with the progression of esophageal squamous cell carcinoma", MOLECULAR MEDICINE REPORTS, vol. 19, no. 6, 2 May 2019 (2019-05-02) - June 2019 (2019-06-01), pages 5309 - 5320, XP055771723
DATABASE NUCLEOTIDE 16 April 2005 (2005-04-16), "Homo sapiens BAC clone RP11-284E5 from 2, complete sequence", XP055771728, retrieved from NCBI Database accession no. AC006460.4
SHEN ET AL., J CANCER., vol. 7, no. 10, 2016, pages 1258 - 1264
Attorney, Agent or Firm:
ISIS IP LAW LLC (KR)
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