Title:
PHARMACEUTICAL COMPOSITION CONTAINING HOT WATER EXTRACT OF FRUIT OF VACCINIUM BRACTEATUM THUNB. AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING BENIGN PROSTATIC HYPERPLASIA
Document Type and Number:
WIPO Patent Application WO/2023/090542
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating benign prostatic hyperplasia, the composition containing, as an active ingredient, an extract of the fruit of Vaccinium bracteatum thunb. The composition inhibits the in vitro generation of 5 alpha reductase, dihydrotestosterone, and androgen receptor (AR). In a benign prostatic hyperplasia rat model induced by testosterone, the composition inhibits prostate tissue enlargement, inhibits 5-alpha reductase generation in prostate hypertrophy tissue, relieves enlarged epithelial cells, and inhibits polyps, thus exhibiting an excellent benign prostatic hyperplasia prevention or inhibition effect in animal models.
Inventors:
KIM JAE YONG (KR)
SEO KYU HWA (KR)
LEE GYU OK (KR)
SHIN JA WON (KR)
KIM HYE YOUN (KR)
KIM CHO EEN (KR)
LEE HAK SUNG (KR)
SEO KYU HWA (KR)
LEE GYU OK (KR)
SHIN JA WON (KR)
KIM HYE YOUN (KR)
KIM CHO EEN (KR)
LEE HAK SUNG (KR)
Application Number:
PCT/KR2022/004445
Publication Date:
May 25, 2023
Filing Date:
March 29, 2022
Export Citation:
Assignee:
JEONNAM BIOINDUSTRY FOUND (KR)
KIM JAE YONG (KR)
SEO KYU HWA (KR)
LEE GYU OK (KR)
SHIN JA WON (KR)
KIM HYE YOUN (KR)
KIM CHO EEN (KR)
LEE HAK SUNG (KR)
KIM JAE YONG (KR)
SEO KYU HWA (KR)
LEE GYU OK (KR)
SHIN JA WON (KR)
KIM HYE YOUN (KR)
KIM CHO EEN (KR)
LEE HAK SUNG (KR)
International Classes:
A61K36/45; A23L33/105; A61P13/08
Foreign References:
| KR102176783B1 | 2020-11-10 | |||
| KR20200082554A | 2020-07-08 | |||
| KR20160079884A | 2016-07-06 |
Other References:
HIROTOSHI TSUDA, HISATO KUNITAKE, RYOKO KAWASAKI-TAKAKI, KAZUO NISHIYAMA, MASAO YAMASAKI, HARUKI KOMATSU, CHIZUKO YUKIZAKI: "Antioxidant Activities and Anti-Cancer Cell Proliferation Properties of Natsuhaze (Vaccinium oldhamii Miq.), Shashanbo (V. bracteatum Thunb.) and Blueberry Cultivars", PLANTS, vol. 2, no. 1, pages 57 - 71, XP055562770, DOI: 10.3390/plants2010057
KIM NA-HYUN, JEGAL JONGHWAN, KIM YUN NA, HEO JEONG-DOO, RHO JUNG-RAE, YANG MIN HYE, JEONG EUN JU: "The Effects of Aronia melanocarpa Extract on Testosterone-Induced Benign Prostatic Hyperplasia in Rats, and Quantitative Analysis of Major Constituents Depending on Extract Conditions", NUTRIENTS, vol. 12, no. 6, pages 1575, XP093067536, DOI: 10.3390/nu12061575
KIM NA-HYUN, JEGAL JONGHWAN, KIM YUN NA, HEO JEONG-DOO, RHO JUNG-RAE, YANG MIN HYE, JEONG EUN JU: "The Effects of Aronia melanocarpa Extract on Testosterone-Induced Benign Prostatic Hyperplasia in Rats, and Quantitative Analysis of Major Constituents Depending on Extract Conditions", NUTRIENTS, vol. 12, no. 6, pages 1575, XP093067536, DOI: 10.3390/nu12061575
Attorney, Agent or Firm:
CHOI, Sok Jin (KR)
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