Title:
PHARMACEUTICAL COMPOSITION CONTAINING PEROXIREDOXIN 1 PROTEIN ACTIVITY INHIBITOR AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING BONE DISEASE
Document Type and Number:
WIPO Patent Application WO/2018/143615
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition containing a peroxiredoxin 1 protein activity inhibitor as an active ingredient for preventing or treating a bone disease. Specifically, the peroxiredoxin 1 protein of the present invention induces the differentiation of preosteoclasts, and an antibody against the peroxiredoxin 1 protein inhibits the increase of osteoclasts induced by lipopolysaccharides and the bone loss in a bone loss animal model, so that the peroxiredoxin 1 protein activity inhibitor can be advantageously utilized in the prevention or treatment of a bone disease.
Inventors:
YIM MIJUNG (KR)
KANG JU-HEE (KR)
KANG JU-HEE (KR)
Application Number:
PCT/KR2018/001189
Publication Date:
August 09, 2018
Filing Date:
January 26, 2018
Export Citation:
Assignee:
UNIV SOOKMYUNG WOMENS IND ACAD COOP FOUND (KR)
International Classes:
A61K39/395; A23L33/10; G01N33/50; G01N33/68
Foreign References:
| KR20100124625A | 2010-11-29 |
Other References:
ISHII, T. ET AL.: "Novel Roles of Peroxiredoxins in Inflammation, Cancer and Innate Immunity", JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, vol. 50, no. 2, 18 February 2012 (2012-02-18), pages 91 - 105, XP055529932
KRISHER, T. ET AL.: "Regulation of Osteoclastogenesis by Integrated Signals from Toll-like Receptors", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 115, no. 12, December 2014 (2014-12-01), pages 2146 - 2154, XP055529939
DATABASE NCBI , GenBank 26 August 2016 (2016-08-26), Database accession no. NP_002565.1
DU, .J. ET AL.: "Ovariectomy Upregulated the Expression of Peroxiredoxin 1 & 5 in Osteoblasts of Mice", SCIENTIFIC REPORTS, vol. 6, no. 35995, 27 October 2016 (2016-10-27), pages 1 - 11
"Development of Basic Technology for Aging Control by Regulation of Redox Signaling Network", RESEARCH REPORT, November 2015 (2015-11-01), pages 1 - 192
KRISHER, T. ET AL.: "Regulation of Osteoclastogenesis by Integrated Signals from Toll-like Receptors", JOURNAL OF CELLULAR BIOCHEMISTRY, vol. 115, no. 12, December 2014 (2014-12-01), pages 2146 - 2154, XP055529939
DATABASE NCBI , GenBank 26 August 2016 (2016-08-26), Database accession no. NP_002565.1
DU, .J. ET AL.: "Ovariectomy Upregulated the Expression of Peroxiredoxin 1 & 5 in Osteoblasts of Mice", SCIENTIFIC REPORTS, vol. 6, no. 35995, 27 October 2016 (2016-10-27), pages 1 - 11
"Development of Basic Technology for Aging Control by Regulation of Redox Signaling Network", RESEARCH REPORT, November 2015 (2015-11-01), pages 1 - 192
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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