Title:
PHARMACEUTICAL COMPOSITION CONTAINING TRIAZINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2023/054292
Kind Code:
A1
Abstract:
The present invention provides a pharmaceutical composition containing a compound that exhibits a coronavirus growth inhibitory activity. A pharmaceutical composition containing a compound represented by the formula (wherein: Y is N; R1 represents an optionally substituted aromatic heterocyclic group; R2 represents an optionally substituted 6-membered aromatic carbon ring group; R3 represents an optionally substituted aromatic heterocyclic group; -X- is -NH-; m is 0 or 1; R5a represents a hydrogen atom; R5b represents a hydrogen atom; n is 1; R4a represents a hydrogen atom; and R4b represents a hydrogen atom) or a pharmaceutically acceptable salt thereof.
Inventors:
TACHIBANA YUKI (JP)
UEHARA SHOTA (JP)
UNOH YUTO (JP)
NAKAHARA KENJI (JP)
TAODA YOSHIYUKI (JP)
KASAMATSU KOJI (JP)
YAMATSU YUKIKO (JP)
ANDO SHIGERU (JP)
FUKAO KEITA (JP)
NOBORI HARUAKI (JP)
KURODA TAKAYUKI (JP)
TOBA SHINSUKE (JP)
UEMURA KENTARO (JP)
MARUYAMA YUKI (JP)
SASAKI MICHIHITO (JP)
SAWA HIROFUMI (JP)
UEHARA SHOTA (JP)
UNOH YUTO (JP)
NAKAHARA KENJI (JP)
TAODA YOSHIYUKI (JP)
KASAMATSU KOJI (JP)
YAMATSU YUKIKO (JP)
ANDO SHIGERU (JP)
FUKAO KEITA (JP)
NOBORI HARUAKI (JP)
KURODA TAKAYUKI (JP)
TOBA SHINSUKE (JP)
UEMURA KENTARO (JP)
MARUYAMA YUKI (JP)
SASAKI MICHIHITO (JP)
SAWA HIROFUMI (JP)
Application Number:
PCT/JP2022/035803
Publication Date:
April 06, 2023
Filing Date:
September 27, 2022
Export Citation:
Assignee:
SHIONOGI & CO (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)
UNIV HOKKAIDO NAT UNIV CORP (JP)
International Classes:
A61K31/5355; A61K31/53; A61K31/5377; A61P31/12; A61P31/14; A61P43/00
Domestic Patent References:
| WO2022138987A1 | 2022-06-30 | |||
| WO2022158528A1 | 2022-07-28 | |||
| WO2022212314A1 | 2022-10-06 | |||
| WO2019087884A1 | 2019-05-09 | |||
| WO2012020749A1 | 2012-02-16 | |||
| WO2013089212A1 | 2013-06-20 | |||
| WO2010092966A1 | 2010-08-19 | |||
| WO2014200078A1 | 2014-12-18 | |||
| WO2021205298A1 | 2021-10-14 | |||
| WO2021250648A1 | 2021-12-16 | |||
| WO2012020742A1 | 2012-02-16 | |||
| WO2013118855A1 | 2013-08-15 |
Foreign References:
| JP2002509140A | 2002-03-26 |
Other References:
LIU YUZHI; LIANG CHENGYUAN; XIN LIANG; REN XIAODONG; TIAN LEI; JU XINGKE; LI HAN; WANG YONGBO; ZHAO QIANQIAN; LIU HONG; CAO WENQIA: "The development of Coronavirus 3C-Like protease (3CLpro) inhibitors from 2010 to 2020", EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 206, 6 August 2020 (2020-08-06), AMSTERDAM, NL , XP086299093, ISSN: 0223-5234, DOI: 10.1016/j.ejmech.2020.112711
THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 382, 2020, pages 1564 - 1567
SCIENCE, vol. 300, 2003, pages 1763 - 1767
CELL RESEARCH, vol. 30, 2020, pages 678 - 692
SCIENCE, vol. 368, 2020, pages 409 - 412
ACS CENTRAL SCIENCE, vol. 7, no. 3, 2021, pages 467 - 475
CANCER TREATMENT REVIEWS, vol. 11, no. 1, 1984, pages 99 - 110
CONTRIBUTIONS TO ONCOLOGY, vol. 18, 1984, pages 221 - 234
ARZNEIMITTEL-FORSCHUNG, vol. 6, 1984, pages 663 - 668
SCIENCE, vol. 374, 2021, pages 1586 - 1593
ATHERTON, E.SHEPPARD, R. C: "In Solid Phase Peptide Synthesis, A Practical Approach", 1989, IRL PRESS AT OXFORD UNIVERSITY PRES
BIOORG. MED. CHEM., vol. 5, 1997, pages 1883 - 1891
JOURNAL OF CLINICAL MICROBIOLOGY., vol. 3, no. 11, 4 June 2005 (2005-06-04), pages 5452 - 5456
THE NEW ENGLAND JOURNAL OF MEDICINE, vol. 382, 2020, pages 1564 - 1567
SCIENCE, vol. 300, 2003, pages 1763 - 1767
CELL RESEARCH, vol. 30, 2020, pages 678 - 692
SCIENCE, vol. 368, 2020, pages 409 - 412
ACS CENTRAL SCIENCE, vol. 7, no. 3, 2021, pages 467 - 475
CANCER TREATMENT REVIEWS, vol. 11, no. 1, 1984, pages 99 - 110
CONTRIBUTIONS TO ONCOLOGY, vol. 18, 1984, pages 221 - 234
ARZNEIMITTEL-FORSCHUNG, vol. 6, 1984, pages 663 - 668
SCIENCE, vol. 374, 2021, pages 1586 - 1593
ATHERTON, E.SHEPPARD, R. C: "In Solid Phase Peptide Synthesis, A Practical Approach", 1989, IRL PRESS AT OXFORD UNIVERSITY PRES
BIOORG. MED. CHEM., vol. 5, 1997, pages 1883 - 1891
JOURNAL OF CLINICAL MICROBIOLOGY., vol. 3, no. 11, 4 June 2005 (2005-06-04), pages 5452 - 5456
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
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