Title:
PHARMACEUTICAL COMPOSITION CONTAINING VITAMIN K2 FOR IMPROVING CARDIOVASCULAR CALCIFICATION, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/178799
Kind Code:
A1
Abstract:
A pharmaceutical composition containing vitamin K2 for improving cardiovascular calcification. The pharmaceutical composition is composed of composition I, composition II, and composition III, the mass ratio of which is (0.1-5):(0.01-0.5):(100-500). Also provided are a preparation method for the pharmaceutical composition and use thereof. The pharmaceutical composition can comprehensively prevent and block cardiovascular calcification, is particularly suitable for reversing a cardiovascular calcification symptom caused by taking statin drugs, and also provides an effect of daily supporting and protecting heart health. Each active ingredient of the pharmaceutical composition is stable, and the pharmaceutical composition has high bioavailability, has a strong targeting property, has no side effects, and can achieve the purpose of prevention and treatment at the same time.
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Inventors:
HE TIANMING (CN)
SHI LUQIU (CN)
XUE HONGYU (CN)
SU GUIZHEN (CN)
SHI LUQIU (CN)
XUE HONGYU (CN)
SU GUIZHEN (CN)
Application Number:
PCT/CN2022/090653
Publication Date:
September 28, 2023
Filing Date:
April 29, 2022
Export Citation:
Assignee:
NANJING SHENGDE NSTITUTE OF BIOTECHNOLOGY CO LTD (CN)
NANJING YI SHENG KANG PIN BIOLOGY SCIENCE AND TECH CO LTD (CN)
NANJING YI SHENG KANG PIN BIOLOGY SCIENCE AND TECH CO LTD (CN)
International Classes:
A61K31/593; A23L33/10; A23L33/12; A23L33/125; A23L33/155; A23L33/18; A23P10/30; A61K9/50; A61K31/122; A61K45/06; A61P9/00; A61P9/10; A61P19/08; A61P35/00; A61P37/04; A61P39/06; A61K31/202; A61K31/4745
Foreign References:
| EP1728507A1 | 2006-12-06 | |||
| CN101534807A | 2009-09-16 | |||
| CN103687495A | 2014-03-26 | |||
| CN113631156A | 2021-11-09 | |||
| CN108969540A | 2018-12-11 | |||
| CN112515172A | 2021-03-19 |
Other References:
LEE SU MI, AN WON SUK: "Supplementary nutrients for prevention of vascular calcification in patients with chronic kidney disease", KOREAN JOURNAL OF INTERNAL MEDICINE KOREA (SOUTH), vol. 34, no. 3, 1 May 2019 (2019-05-01), pages 459 - 469, XP093094608, ISSN: 1226-3303, DOI: 10.3904/kjim.2019.125
KNAPEN, M. H. J. ET AL.: "Steady-state vitamin K2 (menaquinone-7) plasma concentrations after intake of dairy products and soft gel capsules", EUROPEAN JOURNAL OF CLINICAL NUTRITION, vol. 70, no. 7, 24 February 2016 (2016-02-24), pages 831 - 836, XP037766955, DOI: 10.1038/ejcn.2016.3
KNAPEN, M. H. J. ET AL.: "Steady-state vitamin K2 (menaquinone-7) plasma concentrations after intake of dairy products and soft gel capsules", EUROPEAN JOURNAL OF CLINICAL NUTRITION, vol. 70, no. 7, 24 February 2016 (2016-02-24), pages 831 - 836, XP037766955, DOI: 10.1038/ejcn.2016.3
Attorney, Agent or Firm:
NANJING ZHONGQING KEZHI INTELLECTUAL PROPERTY AGENCY OFFICE (GENERAL PARTNERSHIP) (CN)
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