Title:
PHARMACEUTICAL COMPOSITION FOR EXTERNAL USE
Document Type and Number:
WIPO Patent Application WO/2015/151989
Kind Code:
A1
Abstract:
[Problem] The objective of the present invention is to provide a preparation technique with which yellowing that occurs over time or in high-temperature conditions can be suppressed and excellent storage stability can be provided even when diclofenac and/or a salt thereof and a tocopherol and/or derivative thereof are included in a pharmaceutical composition for external use that includes water. [Solution] Provided is a pharmaceutical composition for external use that includes diclofenac and/or a salt thereof, a tocopherol and/or derivative thereof, and water, wherein by mixing in lactic acid and/or a salt thereof, yellowing that occurs over time or in high-temperature conditions can be suppressed, and excellent storage stability can be provided.
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Inventors:
ADO KAZUYOSHI (JP)
IMAI KOZUE (JP)
IMAI KOZUE (JP)
Application Number:
PCT/JP2015/059321
Publication Date:
October 08, 2015
Filing Date:
March 26, 2015
Export Citation:
Assignee:
KOBAYASHI PHARMA (JP)
International Classes:
A61K31/196; A61K9/08; A61K31/355; A61K47/10; A61K47/12; A61P19/02; A61P29/00; A61P43/00
Domestic Patent References:
| WO1992007561A1 | 1992-05-14 |
Foreign References:
| CH699814B1 | 2010-05-14 | |||
| JP2005336063A | 2005-12-08 | |||
| JPH0648939A | 1994-02-22 |
Other References:
DR. H. BARTSCH: "Ergebnis und Auswertung einer Doppelblind-Studie mit Vitamin E und Diclofenac-Natrium sowie der Kombination Vitamin E plus Diclofenac-Natrium bei entzu''ndlich aktivierter Gonarthrose", FAT SCIENCE TECHNOLOGY, vol. 92, no. 5, 1990, pages 197 - 201
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