Title:
PHARMACEUTICAL COMPOSITION OF FORSKOLIN-ISOFORSKOLIN AND PENTACYCLIC TRITERPENOID COMPOUND, AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2022/178967
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition, comprising two components: the first component is selected from forskolin, isoforskolin, or a pharmaceutically acceptable salt thereof; the second component is selected from a pentacyclic triterpenoid compound or a pharmaceutically acceptable salt thereof. According to the pharmaceutical composition in the present invention, forskolin-isoforskolin is used in combination with a pentacyclic triterpenoid compound; compared with the use of the two components alone, a significant synergistic effect on the prevention and treatment of metabolic, fibrotic, and liver diseases can be achieved; thus, the present invention has a wide medicinal prospect in treatment, prevention, and relief of diseases such as obesity, non-alcoholic fatty liver disease, liver injury, and hepatic fibrosis.
Inventors:
WU LIANG (CN)
Application Number:
PCT/CN2021/090005
Publication Date:
September 01, 2022
Filing Date:
April 26, 2021
Export Citation:
Assignee:
UNIV CHINA PHARMA (CN)
International Classes:
A61K31/56; A61K31/352; A61K31/70; A61K31/7024; A61K31/704; A61P1/16; A61P3/04; A61P3/06; A61P3/08; A61P3/10; A61P9/00; A61P9/12; C07D311/92
Domestic Patent References:
| WO2014040632A1 | 2014-03-20 |
Foreign References:
| CN1512889A | 2004-07-14 | |||
| CN109875992A | 2019-06-14 | |||
| DE102009028996A1 | 2011-03-03 | |||
| CN105560092A | 2016-05-11 |
Other References:
WANG YAQIN: "Studies on Chemical Constituents from Coleus Forskohlii and Quality Evaluation of Its Extract", MASTER THESIS, TIANJIN POLYTECHNIC UNIVERSITY, CN, no. 12, 15 December 2009 (2009-12-15), CN , XP055961718, ISSN: 1674-0246
WANG CONG-RONG, GU LI-YAN, LIU YA-BING, WANG CHUN-YONG, LIANG WEI: "Effects of Forscolin on Body Fat, Blood Lipid Contents and Physical Performance in Mice", JOURNAL OF BEIJING UNIVERSITY OF PHYSICAL EDUCATION, vol. 23, no. 3, 30 September 2000 (2000-09-30), pages 330 - 331, XP009539306, ISSN: 1007-3612, DOI: 10.19582/j.cnki.11-3785/g8.2000.03.016
SHAN, YUPEI ET AL.: "Isolation and Identification of Terpenes from Coleus forskohlii", CHINESE JOURNAL OF NATURAL MEDICINES; ISSN 2672-3651, vol. 4, no. 4, 31 July 2006 (2006-07-31), pages 271 - 274, XP009539284
WANG CONG-RONG, GU LI-YAN, LIU YA-BING, WANG CHUN-YONG, LIANG WEI: "Effects of Forscolin on Body Fat, Blood Lipid Contents and Physical Performance in Mice", JOURNAL OF BEIJING UNIVERSITY OF PHYSICAL EDUCATION, vol. 23, no. 3, 30 September 2000 (2000-09-30), pages 330 - 331, XP009539306, ISSN: 1007-3612, DOI: 10.19582/j.cnki.11-3785/g8.2000.03.016
SHAN, YUPEI ET AL.: "Isolation and Identification of Terpenes from Coleus forskohlii", CHINESE JOURNAL OF NATURAL MEDICINES; ISSN 2672-3651, vol. 4, no. 4, 31 July 2006 (2006-07-31), pages 271 - 274, XP009539284
Attorney, Agent or Firm:
CENTRAL SOUTH WELL INTELLECTUAL PROPERTY OFFICE (CN)
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