Title:
PHARMACEUTICAL COMPOSITION, MEGASPHAERA, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/208225
Kind Code:
A1
Abstract:
Provided are Megasphaera sp. strains preserved in Guangdong Microbial Culture Collection Center, with preservation numbers of GDMCC No: 62001, GDMCC No: 62000, and GDMCC No: 61999, respectively. 16S rRNAs of the strains are set forth in SEQ ID NOs: 1-3, respectively. The bacterial strains produce high yields of butyric acid and/or acetic acid. Further provided is use of the strains in the preparation of a pharmaceutical composition for preventing and/or treating tumors.
Inventors:
HUANG BAOJIA (CN)
ZHANG DONGYA (CN)
ZHAO GUOZHEN (CN)
JIANG XIANZHI (CN)
ZHANG DONGYA (CN)
ZHAO GUOZHEN (CN)
JIANG XIANZHI (CN)
Application Number:
PCT/CN2023/091798
Publication Date:
November 02, 2023
Filing Date:
April 28, 2023
Export Citation:
Assignee:
MOON GUANGZHOU BIOTECH CO LTD (CN)
International Classes:
A61K35/74; C12N1/20; A61P35/00; C12R1/01
Foreign References:
| CN110545828A | 2019-12-06 | |||
| CN112239741A | 2021-01-19 | |||
| CN113382740A | 2021-09-10 | |||
| CN111372596A | 2020-07-03 |
Other References:
MAKI JOEL J., LOOFT TOREY: "Megasphaera stantonii sp. nov., a butyrate-producing bacterium isolated from the cecum of a healthy chicken", INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY, SOCIETY FOR GENERAL MICROBIOLOGY, GB, vol. 68, no. 11, 1 November 2018 (2018-11-01), GB , pages 3409 - 3415, XP093100479, ISSN: 1466-5026, DOI: 10.1099/ijsem.0.002991
DATABASE Nucleotide 25 August 2020 (2020-08-25), ANONYMOUS: "Megasphaera hominis Strain NSJ-59 16S Ribosomal RNA Gene, Partial Sequence", XP093100480, retrieved from NCBI Database accession no. MT905219.1
SAMANTHA YUILLE ET AL.: "Human Gut Bacteria as Potent Class I Histone Deacetylase Inhibitors In Vitro through Production of Butyric Acid and Valeric Acid", PLOS ONE, vol. 13, no. 7, 27 July 2018 (2018-07-27), XP009508155, DOI: 10.1371/journal.pone.0201073
SUDARSHAN ANAND SHETTY ET AL.: "Comparative Genome Analysis of Megasphaera sp. Reveals Niche Specialization and Its Potential Role in the Human Gut", PLOS ONE, vol. 8, no. 11, 18 November 2013 (2013-11-18), XP093003485, DOI: 10.1371/journal.pone.0079353
DATABASE Nucleotide 25 August 2020 (2020-08-25), ANONYMOUS: "Megasphaera hominis Strain NSJ-59 16S Ribosomal RNA Gene, Partial Sequence", XP093100480, retrieved from NCBI Database accession no. MT905219.1
SAMANTHA YUILLE ET AL.: "Human Gut Bacteria as Potent Class I Histone Deacetylase Inhibitors In Vitro through Production of Butyric Acid and Valeric Acid", PLOS ONE, vol. 13, no. 7, 27 July 2018 (2018-07-27), XP009508155, DOI: 10.1371/journal.pone.0201073
SUDARSHAN ANAND SHETTY ET AL.: "Comparative Genome Analysis of Megasphaera sp. Reveals Niche Specialization and Its Potential Role in the Human Gut", PLOS ONE, vol. 8, no. 11, 18 November 2013 (2013-11-18), XP093003485, DOI: 10.1371/journal.pone.0079353
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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