PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION

Title:

PHARMACEUTICAL COMPOSITION FOR ORAL ADMINISTRATION

Document Type and Number:

WIPO Patent Application WO/2014/157603

Kind Code:

A1

Abstract:

Provided is a pharmaceutical composition for oral administration, said pharmaceutical composition comprising as an active ingredient 4-{[(1R,2s,3S,5s, 7s)-5-hydroxy-2-adamantyl]amino}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide, the solubility of which varies between in an acidic pH range and in a neutral pH range, having quick disintegration properties and quick elution properties and holding promise for good drug compliance. The pharmaceutical composition for oral administration according to the present invention, which comprises 4-{[(1R,2s,3S,5s, 7s)-5-hydroxy-2-adamantyl]amino}-1H-pyrrolo[2,3-b]pyridine-5-carboxamide or a pharmaceutically acceptable salt thereof and a hydrophilic lubricating agent, is useful as a pharmaceutical composition for oral administration that has quick disintegration properties and quick elution properties and holds promise for good drug compliance.

Inventors:

TAKAE SEIJI (JP)
KOJIMA HIROYUKI (JP)
SAKURAI ATSUSHI (JP)
TAMURA TETSUYA (JP)
TASAKI HIROAKI (JP)
MURO ATSUSHI (JP)

Application Number:

PCT/JP2014/059078

Publication Date:

October 02, 2014

Filing Date:

March 28, 2014

Export Citation:

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Assignee:

ASTELLAS PHARMA INC (JP)

International Classes:

A61K31/437; A61K9/20; A61K9/30; A61K47/10; A61K47/14; A61P29/00; A61P37/02; A61P37/08; A61P43/00

Domestic Patent References:

WO2013022059A1	2013-02-14
WO2012002547A1	2012-01-05
WO2007077949A1	2007-07-12
WO2011162300A1	2011-12-29
WO2011142478A1	2011-11-17

Foreign References:

JP2009522206A	2009-06-11
JP2004131393A	2004-04-30

Other References: