Title:
PHARMACEUTICAL COMPOSITION FOR OTIC ADMINISTRATION
Document Type and Number:
WIPO Patent Application WO/2021/020535
Kind Code:
A1
Abstract:
Provided is a pharmaceutical composition that can be otically administered without a complicated procedure, and that has the function of retaining and gradually releasing a medication within the ear. The pharmaceutical composition for otic administration contains one or more types of medication and a polymer, and has complex viscosity properties wherein, when the complex viscosity of the pharmaceutical composition is measured using a rheometer under conditions of 5% shear strain and 50 rad/sec angular frequency while heating the temperature from 25°C to 37°C at a heating rate of 1°C/10 sec, the complex viscosity is less than 1,650 mPa·s when at 25°C and is 1,650 mPa·s to 100,000 mPa·s, inclusive, at 10 minutes after reaching 37°C.
Inventors:
YOSHIDA TAKATSUNE (JP)
OSADA MARI (JP)
MATSUDA TAKAYA (JP)
SHIMADA KEN (JP)
KOJIMA HIROYUKI (JP)
NAGAKURA AKIRA (JP)
OSADA MARI (JP)
MATSUDA TAKAYA (JP)
SHIMADA KEN (JP)
KOJIMA HIROYUKI (JP)
NAGAKURA AKIRA (JP)
Application Number:
PCT/JP2020/029342
Publication Date:
February 04, 2021
Filing Date:
July 30, 2020
Export Citation:
Assignee:
ASTELLAS PHARMA INC (JP)
International Classes:
A61K45/00; A61K31/7088; A61K38/02; A61K45/06; A61K47/02; A61K47/12; A61K47/32; A61K47/34; A61P27/16; A61P43/00; C07K14/485
Domestic Patent References:
| WO2001068079A2 | 2001-09-20 | |||
| WO2014186075A2 | 2014-11-20 | |||
| WO2011049958A2 | 2011-04-28 | |||
| WO2008124467A1 | 2008-10-16 |
Foreign References:
| JP2013508381A | 2013-03-07 | |||
| JP2018509473A | 2018-04-05 |
Other References:
JAMES M. CHAMBERLAIN ET AL., ANNALS OF ENERGENCY MEDICINE, vol. 25, no. 1, 1995, pages 15 - 20
JAMES M CHAMBERLAIN ET AL., ANNALS OF EMERGENCY MEDICINE, vol. 25, no. 1, 1995, pages 15 - 20
XIAOBO WANG, AUDIOL NEUROTOL, vol. 14, 2009, pages 393 - 401
KIM ET AL., J BIOMED MATER RES B APPL BIOMATER., vol. 102, no. 7, October 2014 (2014-10-01), pages 1393 - 1406
HIRAYAMA ET AL., BIOORG MED CHEM, vol. 5, no. 4, 1997, pages 765 - 778
JAMES M CHAMBERLAIN ET AL., ANNALS OF EMERGENCY MEDICINE, vol. 25, no. 1, 1995, pages 15 - 20
XIAOBO WANG, AUDIOL NEUROTOL, vol. 14, 2009, pages 393 - 401
KIM ET AL., J BIOMED MATER RES B APPL BIOMATER., vol. 102, no. 7, October 2014 (2014-10-01), pages 1393 - 1406
HIRAYAMA ET AL., BIOORG MED CHEM, vol. 5, no. 4, 1997, pages 765 - 778
Attorney, Agent or Firm:
YAMAGUCHI Kenjiro et al. (JP)
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