Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING CARNITINE ACYLCARNITINE CARRIER INHIBITOR AND ANTICANCER AGENT
Document Type and Number:
WIPO Patent Application WO/2023/048506
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating cancer, comprising a carnitine acylcarnitine carrier (CAC) inhibitor and an anticancer agent, and an anticancer adjuvant. The composition comprising a CAC inhibitor and an anticancer agent, according to the present invention, not only significantly reduced the growth of various cancer cells compared to when the CAC inhibitor or the anticancer agent is used alone, but was also confirmed to have a synergistic anticancer effect according to combined administration of the CAC inhibitor and the anticancer agent even in a xenograft tumor animal model. Therefore, the composition of the present invention can be effectively used as an effective anticancer agent for combined use.
Inventors:
KIM SOO YOUL (KR)
Application Number:
PCT/KR2022/014279
Publication Date:
March 30, 2023
Filing Date:
September 23, 2022
Export Citation:
Assignee:
NAT CANCER CT (KR)
NEW CANCER CURE BIO CO LTD (KR)
NEW CANCER CURE BIO CO LTD (KR)
International Classes:
A61K31/4439; A61K31/337; A61K31/4745; A61K31/7068; A61K33/243; A61K45/06; A61P35/00
Foreign References:
| US20080160106A1 | 2008-07-03 | |||
| KR20200005662A | 2020-01-15 | |||
| KR20200041806A | 2020-04-22 |
Other References:
GAO HUAN; WANG XIANGFENG; QU XIAOYU; ZHAI JINGHUI; TAO LINA; ZHANG YUEMING; SONG YANQING; ZHANG WENRUI: "Omeprazole attenuates cisplatin-induced kidney injury through suppression of the TLR4/NF-κB/NLRP3 signaling pathway", TOXICOLOGY, LIMERICK, IR, vol. 440, 11 May 2020 (2020-05-11), IR , XP086177428, ISSN: 0300-483X, DOI: 10.1016/j.tox.2020.152487
JESSICA M. VAN DER BOL; WALTER J. LOOS; FLORIS A. DE JONG; ESTHER VAN MEERTEN; INGE R.H.M. KONINGS; MEI H. LAM; PETER DE BRUIJN; E: "Effect of omeprazole on the pharmacokinetics and toxicities of irinotecan in cancer patients: A prospective cross-over drugdrug interaction study", EUROPEAN JOURNAL OF CANCER, ELSEVIER, AMSTERDAM NL, vol. 47, no. 6, 26 November 2010 (2010-11-26), Amsterdam NL , pages 831 - 838, XP028369387, ISSN: 0959-8049, DOI: 10.1016/j.ejca.2010.11.030
JESSICA M. VAN DER BOL; WALTER J. LOOS; FLORIS A. DE JONG; ESTHER VAN MEERTEN; INGE R.H.M. KONINGS; MEI H. LAM; PETER DE BRUIJN; E: "Effect of omeprazole on the pharmacokinetics and toxicities of irinotecan in cancer patients: A prospective cross-over drugdrug interaction study", EUROPEAN JOURNAL OF CANCER, ELSEVIER, AMSTERDAM NL, vol. 47, no. 6, 26 November 2010 (2010-11-26), Amsterdam NL , pages 831 - 838, XP028369387, ISSN: 0959-8049, DOI: 10.1016/j.ejca.2010.11.030
Attorney, Agent or Firm:
PADO IP LAW PLLC (KR)
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