Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING FIBROSIS, COMPRISING ISOLATED MITOCHONDRIA
Document Type and Number:
WIPO Patent Application WO/2022/098143
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating fibrosis and, more specifically, to a pharmaceutical composition for preventing or treating fibrosis, comprising mitochondria as an active ingredient. When a pharmaceutical composition comprising exogenous mitochondria as an active ingredient, of the present invention, is administered to an individual afflicted with fibrosis such as pulmonary fibrosis, hepatic fibrosis and renal fibrosis, the fibrosis of tissues can be inhibited. In addition, the pharmaceutical composition of the present invention can effectively inhibit the expression of fibronetin, CTGF2, α-SMA, collagen 1A and the like during treatment of TGF-β. Therefore, a pharmaceutical composition according to the present invention can be effectively used in the prevention or treatment of fibrosis.
Inventors:
KIM CHUN-HYUNG (KR)
HAN KYUBOEM (KR)
YU SHIN-HYE (KR)
KIM YU JIN (KR)
LEE SEO-EUN (KR)
PARK JONG HYEOK (KR)
CHO GAYOUNG (KR)
HAN KYUBOEM (KR)
YU SHIN-HYE (KR)
KIM YU JIN (KR)
LEE SEO-EUN (KR)
PARK JONG HYEOK (KR)
CHO GAYOUNG (KR)
Application Number:
PCT/KR2021/016000
Publication Date:
May 12, 2022
Filing Date:
November 05, 2021
Export Citation:
Assignee:
PAEAN BIOTECHNOLOGY INC (KR)
International Classes:
A61K35/28; A61P43/00
Domestic Patent References:
| WO2019060297A1 | 2019-03-28 |
Foreign References:
| KR20200126341A | 2020-11-06 | |||
| KR20180071030A | 2018-06-27 |
Other References:
BLANCO ELVIN: "Mitochondrial Transplantation: A Novel Therapy for Lung Fibrosis", TECHNICAL REPORT OF THE METHODIST HOSPITAL RESEARCH INSTITUTE, METHODIST HOSPITAL RESEARCH INSTITUTE, 1 July 2020 (2020-07-01), pages 1 - 18, XP055931185, Retrieved from the Internet [retrieved on 20220614]
LI XINYU, ZHANG WEI, CAO QINGTAI, WANG ZEYU, ZHAO MINGYI, XU LINYONG, ZHUANG QUAN: "Mitochondrial dysfunction in fibrotic diseases", CELL DEATH DISCOVERY, NATURE PUBLISHING GROUP, UK, vol. 6, no. 1, 1 December 2020 (2020-12-01), UK , pages 80, XP055931188, ISSN: 2058-7716, DOI: 10.1038/s41420-020-00316-9
DUFFERIELD JS ET AL., ANNU. REV. PATHOL. MECH. DIS, vol. 8, 2013, pages 241 - 276
See also references of EP 4241776A4
LI XINYU, ZHANG WEI, CAO QINGTAI, WANG ZEYU, ZHAO MINGYI, XU LINYONG, ZHUANG QUAN: "Mitochondrial dysfunction in fibrotic diseases", CELL DEATH DISCOVERY, NATURE PUBLISHING GROUP, UK, vol. 6, no. 1, 1 December 2020 (2020-12-01), UK , pages 80, XP055931188, ISSN: 2058-7716, DOI: 10.1038/s41420-020-00316-9
DUFFERIELD JS ET AL., ANNU. REV. PATHOL. MECH. DIS, vol. 8, 2013, pages 241 - 276
See also references of EP 4241776A4
Attorney, Agent or Firm:
RYU, Jong Woo et al. (KR)
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