Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING HYPERTENSIVE DISEASE COMPRISING ISOLATED MITOCHONDRIA AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2023/234678
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating a hypertensive disease, comprising isolated mitochondria as an active ingredient. When the pharmaceutical composition comprising isolated mitochondria as an active ingredient, according to the present invention, is administered to an individual suffering from a hypertensive disease, the blood pressure of the individual can be lowered. In addition, the pharmaceutical composition can restore damaged blood vessels in the placenta of individuals suffering from hypertension in pregnancy among hypertensive diseases. Moreover, the pharmaceutical composition can normalize side effects, such as low fetal weight and fetal growth restriction, due to a hypertensive disease in pregnancy. Therefore, the pharmaceutical composition according to the present invention can be effectively used in the prevention or treatment of hypertensive diseases, particularly hypertension in pregnancy and resistant hypertension.
Inventors:
KANG YOUNG CHEOL (KR)
HAN KYUBOEM (KR)
KIM CHUN-HYUNG (KR)
KIM SOOMIN (KR)
ZHANG YIN HUA (KR)
CUI HUI XING (KR)
HAN KYUBOEM (KR)
KIM CHUN-HYUNG (KR)
KIM SOOMIN (KR)
ZHANG YIN HUA (KR)
CUI HUI XING (KR)
Application Number:
PCT/KR2023/007392
Publication Date:
December 07, 2023
Filing Date:
May 30, 2023
Export Citation:
Assignee:
PAEAN BIOTECHNOLOGY INC (KR)
SEOUL NAT UNIV R&DB FOUNDATION (KR)
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
A61K35/12; A61P9/12; A61P43/00
Domestic Patent References:
| WO2020202103A1 | 2020-10-08 |
Foreign References:
| KR20220041145A | 2022-03-31 | |||
| KR20220037435A | 2022-03-24 | |||
| CN110022884A | 2019-07-16 |
Other References:
SMITH ALEX N, WANG XI, THOMAS DANIEL G, TATUM ROBERT E, BOOZ GEORGE W, CUNNINGHAM MARK W: "The Role of Mitochondrial Dysfunction in Preeclampsia: Causative Factor or Collateral Damage?", AMERICAN JOURNAL OF HYPERTENSION, NATURE PUBLISHING GROUP, UNITED STATES, vol. 34, no. 5, 22 May 2021 (2021-05-22), United States , pages 442 - 452, XP093116228, ISSN: 0895-7061, DOI: 10.1093/ajh/hpab003
Attorney, Agent or Firm:
RYU, Jong Woo et al. (KR)
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