Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY SKIN DISEASES, CONTAINING INTERLEUKIN-32 PROTEIN AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2021/002739
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating inflammatory skin diseases, containing interleukin-32 protein as an active ingredient. Specifically, interleukin-32 protein of the present invention alleviates inflammation of the skin in an animal model with atopic dermatitis, inhibits an increase in skin thickness and mast cells, inhibits the blood level and expression of inflammatory cytokines, and inhibits an increase in inflammatory cytokines that are also in skin keratinocytes, thereby being effectively usable in the treatment of inflammatory skin diseases.
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Inventors:
HONG JIN TAE (KR)
LEE YONG SUN (KR)
LEE YONG SUN (KR)
Application Number:
PCT/KR2020/095041
Publication Date:
January 07, 2021
Filing Date:
March 18, 2020
Export Citation:
Assignee:
NAT UNIV CHUNGBUK IND ACAD COOP FOUND (KR)
International Classes:
A61K38/20; A61K8/64; A61K9/00; A61P17/00; A61P29/00; A61Q19/00
Foreign References:
| KR20110132735A | 2011-12-09 | |||
| KR20160106952A | 2016-09-13 |
Other References:
BO-RAM BANG, HYOUK-SOO KWON, SOO-HYUN KIM, SUN-YOUNG YOON, JI-DA CHOI, GYONG HWA HONG, SUNJOO PARK, TAE-BUM KIM, HEE-BOM MOON, YOU: "Interleukin-32γ Suppresses Allergic Airway Inflammation in Mouse Models of Asthma", AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY., AMERICAN LUNG ASSOCIATION, NEW YORK, NY, US, vol. 50, no. 6, 1 June 2014 (2014-06-01), NEW YORK, NY, US, pages 1021 - 1030, XP055771230, ISSN: 1044-1549, DOI: 10.1165/rcmb.2013-0234OC
RODRIGO SAAR GOMES, MURIEL VILELA TEODORO SILVA, JÉSSICA CRISTINA DOS SANTOS, LUCAS LUIZ DE LIMA SILVA, ALINE CARVALHO BATISTA, JU: "IL-32γ promotes the healing of murine cutaneous lesions caused by Leishmania braziliensis infection in contrast to Leishmania amazonensis", PARASITES & VECTORS, vol. 10, no. 1, 1 December 2017 (2017-12-01), XP055771239, DOI: 10.1186/s13071-017-2268-4
TONG XIN, MO CHEN, LIWEI DUAN, YANLING XU, PENG GAO: "Interleukin-32: its role in asthma and potential as a therapeutic agent", RESPIRATORY RESEARCH, vol. 19, no. 1, 1 December 2018 (2018-12-01), XP055771244, DOI: 10.1186/s12931-018-0832-x
LEE YONG SUN; HAN SANG-BAE; HAM HYEON JOO; PARK JU HO; LEE JONG SUNG; HWANG DAE YEON; JUNG YOUNG SUK; YOON DO YOUNG; HONG JIN TAE: "IL-32γ suppressed atopic dermatitis through inhibition of miR-205 expression via inactivation of nuclear factor-kappa B", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 146, no. 1, 10 January 2020 (2020-01-10), AMSTERDAM, NL, pages 156 - 168, XP086207320, ISSN: 0091-6749, DOI: 10.1016/j.jaci.2019.12.905
RODRIGO SAAR GOMES, MURIEL VILELA TEODORO SILVA, JÉSSICA CRISTINA DOS SANTOS, LUCAS LUIZ DE LIMA SILVA, ALINE CARVALHO BATISTA, JU: "IL-32γ promotes the healing of murine cutaneous lesions caused by Leishmania braziliensis infection in contrast to Leishmania amazonensis", PARASITES & VECTORS, vol. 10, no. 1, 1 December 2017 (2017-12-01), XP055771239, DOI: 10.1186/s13071-017-2268-4
TONG XIN, MO CHEN, LIWEI DUAN, YANLING XU, PENG GAO: "Interleukin-32: its role in asthma and potential as a therapeutic agent", RESPIRATORY RESEARCH, vol. 19, no. 1, 1 December 2018 (2018-12-01), XP055771244, DOI: 10.1186/s12931-018-0832-x
LEE YONG SUN; HAN SANG-BAE; HAM HYEON JOO; PARK JU HO; LEE JONG SUNG; HWANG DAE YEON; JUNG YOUNG SUK; YOON DO YOUNG; HONG JIN TAE: "IL-32γ suppressed atopic dermatitis through inhibition of miR-205 expression via inactivation of nuclear factor-kappa B", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, ELSEVIER, AMSTERDAM, NL, vol. 146, no. 1, 10 January 2020 (2020-01-10), AMSTERDAM, NL, pages 156 - 168, XP086207320, ISSN: 0091-6749, DOI: 10.1016/j.jaci.2019.12.905
Attorney, Agent or Firm:
IPMAGNA INTELLECTUAL PROPERTY LAW FIRM (KR)
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