Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING LIVER DISEASE, COMPRISING BIOIMPLANT COMPRISING MESENCHYMAL STEM CELLS
Document Type and Number:
WIPO Patent Application WO/2020/122666
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating liver diseases, comprising a bioimplant comprising mesenchymal stem cells, wherein the bioimplant comprising mesenchymal stem cells of the present invention can be inserted as a one-time subcutaneous or intraperitoneal implant in hepatic fibrosis animal models, to reduce the levels of AST and ALT, which are indicators of liver damage, as well as the ratio of an area occupied by collagen fibers in liver parenchyma, the number of degenerate hepatic cells, and the number of infiltrated inflammatory cells, and is effective in regenerating the liver, inhibiting hepatic fibrosis, and increasing the expression of growth factors, and thus can be beneficially used for preventing or treating liver diseases.
Inventors:
NOH SEUNG KWON (KR)
LEE CHUL KYU (KR)
KIM SAY-JUNE (KR)
LEE CHUL KYU (KR)
KIM SAY-JUNE (KR)
Application Number:
PCT/KR2019/017692
Publication Date:
June 18, 2020
Filing Date:
December 13, 2019
Export Citation:
Assignee:
THOTHSCIENCE INC (KR)
International Classes:
A61K9/00; A61K35/28; A61P1/16
Foreign References:
| KR20160027341A | 2016-03-10 | |||
| KR20150009441A | 2015-01-26 | |||
| KR20180074557A | 2018-07-03 | |||
| US20090232781A1 | 2009-09-17 | |||
| KR101542849B1 | 2015-08-10 |
Other References:
GUO, L.: "The role of microRNAs in self-renewal and differentiation of mesenchymal stem cells", EXPERIMENTAL HEMATOLOGY, vol. 39, 2011, pages 608 - 616, XP028217379, DOI: 10.1016/j.exphem.2011.01.011
BEDOSSA PPARADIS V, J PATHOL, vol. 200, 2003, pages 504 - 515
BEDOSSA PPARADIS V, J PATHOL, vol. 200, 2003, pages 504 - 515
Attorney, Agent or Firm:
LEE, Won Hee (KR)
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