Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING METABOLIC DISEASES CONTAINING DEMETHYLZEYLASTERAL
Document Type and Number:
WIPO Patent Application WO/2023/239016
Kind Code:
A1
Abstract:
A composition containing demethylzeylasteral or a pharmaceutically acceptable salt thereof according to the present invention is a glucocorticoid receptor antagonist that inhibits intracellular glucocorticoid receptor activity and is highly effective for inhibiting the accumulation of fat cells and thereby preventing and treating metabolic diseases.
Inventors:
YANG HEE (KR)
SHIN SEO HYUN (KR)
HUR GI HYUN (KR)
KIM NA RA (KR)
LEE JOON YOUNG (KR)
KIM YE EUN (KR)
YOON JUNG HAN (KR)
LEE KI WON (KR)
SHIN SEO HYUN (KR)
HUR GI HYUN (KR)
KIM NA RA (KR)
LEE JOON YOUNG (KR)
KIM YE EUN (KR)
YOON JUNG HAN (KR)
LEE KI WON (KR)
Application Number:
PCT/KR2023/003227
Publication Date:
December 14, 2023
Filing Date:
March 09, 2023
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
A61K31/192; A23K10/30; A23K20/111; A23L33/10; A23L33/105; A61K36/37; A61P3/00; A61P9/12
Foreign References:
| JP2015531376A | 2015-11-02 | |||
| KR102470686B1 | 2022-11-23 |
Other References:
HUANG WEI-JUN; LIU WEI-JING; XIAO YONG-HUA; ZHENG HUI-JUAN; XIAO YAO; JIA QI; JIANG HAN-XUE; ZHU ZE-BING; XIA CHEN-HUI; HAN XUE-TI: "Tripterygium and its extracts for diabetic nephropathy: Efficacy and pharmacological mechanisms", BIOMEDICINE & PHARMACOTHERAPY, ELSEVIER, FR, vol. 121, 7 November 2019 (2019-11-07), FR , XP085930349, ISSN: 0753-3322, DOI: 10.1016/j.biopha.2019.109599
HUANG YING, WANG SHAOFENG, ZHANG CHUNYA, XU ZHIQING, SHEN JINGHUA, DU XIAOGANG, ZHANG HUANHUA, ZHANG KANGJIAN, ZHANG DAIFU: "Experimental study of the anti-atherosclerotic effect of demethylzeylasteral", EXPERIMENTAL AND THERAPEUTIC MEDICINE, SPANDIDOS PUBLICATIONS, GR, vol. 13, no. 6, 1 June 2017 (2017-06-01), GR , pages 2787 - 2792, XP093114768, ISSN: 1792-0981, DOI: 10.3892/etm.2017.4352
CHANG BAOCHAO, CHEN WEIDONG, ZHANG YAN, YANG PING, LIU LEI: "Tripterygium wilfordii mitigates hyperglycemia-induced upregulated Wnt/β-catenin expression and kidney injury in diabetic rats", EXPERIMENTAL AND THERAPEUTIC MEDICINE, SPANDIDOS PUBLICATIONS, GR, vol. 15, GR , pages 3874 - 3882, XP093114771, ISSN: 1792-0981, DOI: 10.3892/etm.2018.5901
KANG MYUNG-JI, KWON EUN-BIN, YUK HEUNG JOO, RYU HYUNG WON, KIM SOO-YEON, LEE MI-KYEONG, MOON DONG-OH, LEE SU UI, OH SEI-RYANG, LEE: "Tripterygium regelii decreases the biosynthesis of triacylglycerol and cholesterol in HepG2 cells", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, JP, vol. 81, no. 12, 2 December 2017 (2017-12-02), JP , pages 2285 - 2291, XP093114773, ISSN: 0916-8451, DOI: 10.1080/09168451.2017.1390392
HUANG YING, WANG SHAOFENG, ZHANG CHUNYA, XU ZHIQING, SHEN JINGHUA, DU XIAOGANG, ZHANG HUANHUA, ZHANG KANGJIAN, ZHANG DAIFU: "Experimental study of the anti-atherosclerotic effect of demethylzeylasteral", EXPERIMENTAL AND THERAPEUTIC MEDICINE, SPANDIDOS PUBLICATIONS, GR, vol. 13, no. 6, 1 June 2017 (2017-06-01), GR , pages 2787 - 2792, XP093114768, ISSN: 1792-0981, DOI: 10.3892/etm.2017.4352
CHANG BAOCHAO, CHEN WEIDONG, ZHANG YAN, YANG PING, LIU LEI: "Tripterygium wilfordii mitigates hyperglycemia-induced upregulated Wnt/β-catenin expression and kidney injury in diabetic rats", EXPERIMENTAL AND THERAPEUTIC MEDICINE, SPANDIDOS PUBLICATIONS, GR, vol. 15, GR , pages 3874 - 3882, XP093114771, ISSN: 1792-0981, DOI: 10.3892/etm.2018.5901
KANG MYUNG-JI, KWON EUN-BIN, YUK HEUNG JOO, RYU HYUNG WON, KIM SOO-YEON, LEE MI-KYEONG, MOON DONG-OH, LEE SU UI, OH SEI-RYANG, LEE: "Tripterygium regelii decreases the biosynthesis of triacylglycerol and cholesterol in HepG2 cells", BIOSCIENCE, BIOTECHNOLOGY, AND BIOCHEMISTRY, JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY, JP, vol. 81, no. 12, 2 December 2017 (2017-12-02), JP , pages 2285 - 2291, XP093114773, ISSN: 0916-8451, DOI: 10.1080/09168451.2017.1390392
Attorney, Agent or Firm:
LEECHAE INTELLECTUAL PROPERTY (KR)
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