Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING MUSCLE DISEASES COMPRISING GINSENOSIDES RG2, RG4, RG6, RH1, AND RH4 AS ACTIVE INGREDIENTS
Document Type and Number:
WIPO Patent Application WO/2021/118080
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating muscle diseases, the composition comprising at least one ginsenoside selected from among the ginsenosides Rg2, Rg4, Rg6, Rh1, and Rh4 as an active ingredient. When used to treat muscular atrophy-induced cells or aging-induced mice, the ginsenosides have an excellent effect of promoting differentiation into myotubes, and an excellent effect of regenerating muscle tissue, and thus the ginsenosides can be effectively used for treating muscle diseases, in particular, muscle diseases caused by muscle wasting, muscular degeneration, or decreased muscular function.
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Inventors:
SONG GYU YONG (KR)
AHN BYUNG HEE (KR)
AHN BYUNG HEE (KR)
Application Number:
PCT/KR2020/016007
Publication Date:
June 17, 2021
Filing Date:
November 13, 2020
Export Citation:
Assignee:
AREZ CO LTD (KR)
THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIV (KR)
THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIV (KR)
International Classes:
A61K31/704; A23L33/125; A61P21/00
Foreign References:
| KR20110038758A | 2011-04-15 | |||
| KR20130086726A | 2013-08-05 |
Other References:
SEO YOON-JEONG , LEW JAE-HWAN: "The Effect of Red Ginseng on Sarcopenic Rat", THE KOREAN SOCIETY FOR ORIENTAL INTERNAL MEDICINE, vol. 39, no. 6, 30 December 2018 (2018-12-30), pages 1168 - 1180, XP053039094, ISSN: 1226-9174, DOI: 10.22246/jikm.2018.39.6.1168
XIAONAN WANG, ZHAOYONG HU, JUNPING HU, JIE DU, WILLIAM E. MITCH: "Insulin Resistance Accelerates Muscle Protein Degradation: Activation of the Ubiquitin-Proteasome Pathway by Defects in Muscle Cell Signaling", ENDOCRINOLOGY, vol. 147, no. 9, 1 September 2006 (2006-09-01), pages 4160 - 4168, XP055820282, DOI: 10.1210/en.2006-0251
NAM KI YEUL , KIM YEONG SU , SHON MI YAE , PARK JONG DAE: "Recent Advances in Studies on Chemical Constituents and Biological Activities of Korean Black Ginseng(Panax ginseng C. A. Meyer)", KOREAN JOURNAL OF PHARMACOGNOSY, vol. 46, no. 3, 30 September 2015 (2015-09-30), pages 173 - 188, XP053034968, ISSN: 0253-3073
XIAONAN WANG, ZHAOYONG HU, JUNPING HU, JIE DU, WILLIAM E. MITCH: "Insulin Resistance Accelerates Muscle Protein Degradation: Activation of the Ubiquitin-Proteasome Pathway by Defects in Muscle Cell Signaling", ENDOCRINOLOGY, vol. 147, no. 9, 1 September 2006 (2006-09-01), pages 4160 - 4168, XP055820282, DOI: 10.1210/en.2006-0251
NAM KI YEUL , KIM YEONG SU , SHON MI YAE , PARK JONG DAE: "Recent Advances in Studies on Chemical Constituents and Biological Activities of Korean Black Ginseng(Panax ginseng C. A. Meyer)", KOREAN JOURNAL OF PHARMACOGNOSY, vol. 46, no. 3, 30 September 2015 (2015-09-30), pages 173 - 188, XP053034968, ISSN: 0253-3073
Attorney, Agent or Firm:
GHONG-GAN INTERNATIONAL PATENT LAW FIRM (KR)
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