Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING MUSCULAR WEAKNESS-RELATED DISEASES COMPRISING ALVERINE, 4-HYDROXY ALVERINE, DERIVATIVE THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/206513
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for preventing or treating muscular weakness-related diseases, comprising alverine, 4-hydroxy alverine, a derivative thereof, or a pharmaceutically acceptable salt thereof. When myoblasts are treated with the alverine, 4-hydroxy alverine, derivative thereof, or pharmaceutically acceptable salt thereof of the present invention, differentiation into myotubes is promoted. Therefore, the alverine, 4-hydroxy alverine, derivative thereof, or pharmaceutically acceptable salt thereof according to the present invention can be effectively used in the promotion of differentiation of myoblasts and the prevention or treatment of muscular weakness-related diseases.
Inventors:
KWON KI-SUN (KR)
LEE YOUNGLANG (KR)
YOON JONG HYUN (KR)
LEE SEUNG-MIN (KR)
JEON CHANG HOON (KR)
HA TAI HWAN (KR)
JEONG DO YEUN (KR)
LEE YOUNGLANG (KR)
YOON JONG HYUN (KR)
LEE SEUNG-MIN (KR)
JEON CHANG HOON (KR)
HA TAI HWAN (KR)
JEONG DO YEUN (KR)
Application Number:
PCT/KR2021/004523
Publication Date:
October 14, 2021
Filing Date:
April 09, 2021
Export Citation:
Assignee:
KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)
AVENTI INC (KR)
AVENTI INC (KR)
International Classes:
C07C215/54; A23L33/10; A61K31/133; A61K31/135; A61P21/00; C07C211/03; C12N5/077
Other References:
ANITA ANNAHÁZI, ROKA, RICHARD; ROSZTOCZY, ANDRAS; WITTMANN, TIBOR: "Role of antispasmodics in the treatment of irritable bowel syndrome", WORLD JOURNAL OF GASTROENTEROLOGY, WJG PRESS, CN, vol. 20, no. 20, 28 May 2014 (2014-05-28), CN , pages 6031 - 6043, XP055356010, ISSN: 1007-9327, DOI: 10.3748/wjg.v20.i20.6031
DATABASE REGISTRY STN; 4 November 1999 (1999-11-04), ANONYMOUS : "/1 -(C) FILE REGISTRY RN -246178-12-1 REGISTRY ED -Entered STN: 04 Nov 1999 CN -Benzenepropanamine, N-methyl-N-(3-phenylpropyl)-, ethanedioate (2:1) (CA INDEX NAME) ", XP055856723, retrieved from STN Database accession no. 246178-12-1
DATABASE REGISTRY STN; 2 January 2005 (2005-01-02), ANONYMOUS : "/1 -(C) FILE REGISTRY RN -807264-08-0 REGISTRY ED -Entered STN: 02 Jan 2005 CN -Phenol, 4,4'-[(ethylimino)di-3,1-propanediyl]bis-(9CI) (CA INDEX NAME)", XP055856726, retrieved from STN Database accession no. 807264-08-0
HAYASE M, HASHITANI H, SUZUKI H, KOHRI K, BRADING A F: "Evolving mechanisms of action of alverine citrate on phasic smooth muscles : Paradoxical effects of alverine on smooth muscle", BRITISH JOURNAL OF PHARMACOLOGY, WILEY-BLACKWELL, UK, vol. 152, no. 8, 1 December 2007 (2007-12-01), UK , pages 1228 - 1238, XP055856671, ISSN: 0007-1188, DOI: 10.1038/sj.bjp.0707496
ANNE-MARIE COELHO , LUC JACOB , JEAN FIORAMONTI , LIONEL BUENO: "Rectal antinociceptive properties of alverine citrate are linked to antagonism at the 5-HT1A receptor subtype", JOURNAL OF PHARMACY AND PHARMACOLOGY : JPP, JOHN WILEY & SONS LTD, LONDON, GB, vol. 53, no. 10, 1 January 2001 (2001-01-01), GB , pages 1419 - 1426, XP009025660, ISSN: 0022-3573, DOI: 10.1211/0022357011777783
JU YEON KWAKKI-SUN KWON, ANN GERIATR MED RES, 2019, pages 98 - 104
JIAYU YINXIANG LUZHIYUAN QIANWEITING XUXIANG ZHOU, THERANOSTICS, 2019, pages 4019 - 4029
AJ CRUZ-JENTOFT ET AL., AGE AGEING, 2019, pages 601
JESSICA HIU-TUNG LOKIN PONGUTSZLAMYIU, J ORTHOP TRANSLAT, 2020, pages 38 - 52
CARLSON ET AL., J GERONTOL, 2001, pages B224 - 233
SABOURIN LARUDNICKI MA, CLIN GENET, vol. 57, no. 1, January 2000 (2000-01-01), pages 16 - 25
FRANCESCA RIUZZIGUGLIELMO SORCICATALDO ARCURI, J CACHEXIA SARCOPENIA MUSCLE, 2018, pages 1255 - 1268
MARY F. O'LEARY, SCI REP, 2017, pages 12997
JIN-A KIMSEONG MIN KIM, BMC COMPLEMENT ALTERN MED, vol. 287, 2019
JIN-A KIMSEONG MIN KIM, BMC COMPLEMENT ALTERN
See also references of EP 4134363A1
DATABASE REGISTRY STN; 4 November 1999 (1999-11-04), ANONYMOUS : "/1 -(C) FILE REGISTRY RN -246178-12-1 REGISTRY ED -Entered STN: 04 Nov 1999 CN -Benzenepropanamine, N-methyl-N-(3-phenylpropyl)-, ethanedioate (2:1) (CA INDEX NAME) ", XP055856723, retrieved from STN Database accession no. 246178-12-1
DATABASE REGISTRY STN; 2 January 2005 (2005-01-02), ANONYMOUS : "/1 -(C) FILE REGISTRY RN -807264-08-0 REGISTRY ED -Entered STN: 02 Jan 2005 CN -Phenol, 4,4'-[(ethylimino)di-3,1-propanediyl]bis-(9CI) (CA INDEX NAME)", XP055856726, retrieved from STN Database accession no. 807264-08-0
HAYASE M, HASHITANI H, SUZUKI H, KOHRI K, BRADING A F: "Evolving mechanisms of action of alverine citrate on phasic smooth muscles : Paradoxical effects of alverine on smooth muscle", BRITISH JOURNAL OF PHARMACOLOGY, WILEY-BLACKWELL, UK, vol. 152, no. 8, 1 December 2007 (2007-12-01), UK , pages 1228 - 1238, XP055856671, ISSN: 0007-1188, DOI: 10.1038/sj.bjp.0707496
ANNE-MARIE COELHO , LUC JACOB , JEAN FIORAMONTI , LIONEL BUENO: "Rectal antinociceptive properties of alverine citrate are linked to antagonism at the 5-HT1A receptor subtype", JOURNAL OF PHARMACY AND PHARMACOLOGY : JPP, JOHN WILEY & SONS LTD, LONDON, GB, vol. 53, no. 10, 1 January 2001 (2001-01-01), GB , pages 1419 - 1426, XP009025660, ISSN: 0022-3573, DOI: 10.1211/0022357011777783
JU YEON KWAKKI-SUN KWON, ANN GERIATR MED RES, 2019, pages 98 - 104
JIAYU YINXIANG LUZHIYUAN QIANWEITING XUXIANG ZHOU, THERANOSTICS, 2019, pages 4019 - 4029
AJ CRUZ-JENTOFT ET AL., AGE AGEING, 2019, pages 601
JESSICA HIU-TUNG LOKIN PONGUTSZLAMYIU, J ORTHOP TRANSLAT, 2020, pages 38 - 52
CARLSON ET AL., J GERONTOL, 2001, pages B224 - 233
SABOURIN LARUDNICKI MA, CLIN GENET, vol. 57, no. 1, January 2000 (2000-01-01), pages 16 - 25
FRANCESCA RIUZZIGUGLIELMO SORCICATALDO ARCURI, J CACHEXIA SARCOPENIA MUSCLE, 2018, pages 1255 - 1268
MARY F. O'LEARY, SCI REP, 2017, pages 12997
JIN-A KIMSEONG MIN KIM, BMC COMPLEMENT ALTERN MED, vol. 287, 2019
JIN-A KIMSEONG MIN KIM, BMC COMPLEMENT ALTERN
See also references of EP 4134363A1
Attorney, Agent or Firm:
FIRSTLAW P.C. (KR)
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