Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF ALZHEIMER'S DISEASE
Document Type and Number:
WIPO Patent Application WO/2024/071509
Kind Code:
A1
Abstract:
The present invention may provide a pharmaceutical composition for the prevention or treatment of Alzheimer's disease, the composition containing: an amyloid-beta peptide or a nucleic acid encoding same; and rapamycin or a derivative thereof. The composition can generate antibodies against amyloid-beta to suppress the accumulation of amyloid-beta while inducing amyloid-beta-specific regulatory T cells to suppress inflammatory reactions in the brain affected by Alzheimer's disease. Therefore, the composition can be utilized as an Alzheimer's vaccine composition that is therapeutically excellent and preferably has few side effects.
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Inventors:
KIM BYUNG SOO (KR)
JUNG MUN GYO (KR)
KIM YOUNG SOO (KR)
LEE SONG MIN (KR)
JUNG MUN GYO (KR)
KIM YOUNG SOO (KR)
LEE SONG MIN (KR)
Application Number:
PCT/KR2022/016873
Publication Date:
April 04, 2024
Filing Date:
November 01, 2022
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
UNIV YONSEI IACF (KR)
UNIV YONSEI IACF (KR)
International Classes:
A61K38/17; A61K9/51; A61K31/436; A61K39/00; A61P25/28
Domestic Patent References:
| WO2004014367A2 | 2004-02-19 |
Other References:
ARTI TYAGI: "Integrated Pathways of COX-2 and mTOR: Roles in Cell Sensing and Alzheimer’s Disease", FRONTIERS IN NEUROSCIENCE, FRONTIERS RESEARCH FOUNDATION, CH, vol. 14, 9 July 2020 (2020-07-09), CH , XP093153990, ISSN: 1662-453X, DOI: 10.3389/fnins.2020.00693
DATABASE Protein 5 August 2021 (2021-08-05), ANONYMOUS: "Amyloid-beta A4 protein [Galemys pyrenaicus]", XP093153994, Database accession no. KAG8518514.1
DATABASE Protein 18 February 1994 (1994-02-18), ANONYMOUS: "beta-amyloid-(1-42), A beta-(1-42)=amyloid major component {N-terminal} [human, leptomeningeal blood vessels, Peptide Partial, 19 aa]", XP093153996, Database accession no. AAB29001.1
SUNG PIL KWON: "Nanoparticle‐Mediated Blocking of Excessive Inflammation for Prevention of Heart Failure Following Myocardial Infarction", SMALL, WILEY, HOBOKEN, USA, vol. 17, no. 32, 1 August 2021 (2021-08-01), Hoboken, USA, XP093153998, ISSN: 1613-6810, DOI: 10.1002/smll.202101207
DATABASE Protein 5 August 2021 (2021-08-05), ANONYMOUS: "Amyloid-beta A4 protein [Galemys pyrenaicus]", XP093153994, Database accession no. KAG8518514.1
DATABASE Protein 18 February 1994 (1994-02-18), ANONYMOUS: "beta-amyloid-(1-42), A beta-(1-42)=amyloid major component {N-terminal} [human, leptomeningeal blood vessels, Peptide Partial, 19 aa]", XP093153996, Database accession no. AAB29001.1
SUNG PIL KWON: "Nanoparticle‐Mediated Blocking of Excessive Inflammation for Prevention of Heart Failure Following Myocardial Infarction", SMALL, WILEY, HOBOKEN, USA, vol. 17, no. 32, 1 August 2021 (2021-08-01), Hoboken, USA, XP093153998, ISSN: 1613-6810, DOI: 10.1002/smll.202101207
Attorney, Agent or Firm:
LEECHAE INTELLECTUAL PROPERTY (KR)
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