Title:
PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF RETINAL NEURODEGENERATIVE DISEASES, COMPRISING PROX1 INHIBITOR AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2021/261965
Kind Code:
A1
Abstract:
The present invention relates to a technology for treating retinal neurodegenerative diseases through the regeneration of retinal nerves by targeting Prox1 in the mammalian retina and, more particularly, to: a pharmaceutical composition for the prevention or treatment of retinal neurodegenerative diseases, comprising, as an active ingredient, an inhibitor for inhibiting the expression or migration of Prox1; and a pharmaceutical formulation comprising the composition. The pharmaceutical composition comprising a Prox1 migration inhibitor, according to the present invention, induces the regeneration of damaged retina in mammals, and thus can be commonly applied to the treatment of various retinal neurodegenerative diseases of which there are no effective treatments in the prior art and which cause visual loss. Furthermore, when combined with a selective retinal nerve differentiation method or the like, the pharmaceutical composition is expected to be used in the development of an innovative retinal regeneration method which can selectively regenerate only specific retinal nerve cells undergoing degeneration.
Inventors:
KIM JIN WOO (KR)
LEE EUN JUNG (KR)
LEE EUN JUNG (KR)
Application Number:
PCT/KR2021/008044
Publication Date:
December 30, 2021
Filing Date:
June 25, 2021
Export Citation:
Assignee:
KOREA ADVANCED INST SCI & TECH (KR)
International Classes:
A61K48/00; A61K9/00; A61K39/395; A61K45/06; A61P27/02
Foreign References:
| US20030224516A1 | 2003-12-04 | |||
| KR20150035432A | 2015-04-06 | |||
| KR20190037166A | 2019-04-05 | |||
| KR20110117982A | 2011-10-28 | |||
| KR101268741B1 | 2013-06-04 |
Other References:
DATABASE Genbank - Nucleotide NCBI; 11 September 2007 (2007-09-11), ANONYMOUS : "Homo sapiens prospero homeobox 1, mRNA (cDNA clone MGC:3668 IMAGE:3532", XP055882785, Database accession no. BC024201.2
See also references of EP 4173641A4
See also references of EP 4173641A4
Attorney, Agent or Firm:
ISIS IP LAW LLC (KR)
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