Title:
PHARMACEUTICAL COMPOSITION FOR RELIEVING OR TREATING PAIN BY REGULATING CEREBELLAR GLIAL CELLS AND METHOD FOR RELIEVING OR TREATING PAIN
Document Type and Number:
WIPO Patent Application WO/2023/113429
Kind Code:
A1
Abstract:
The present invention relates to a composition for relieving or treating pain, a method for relieving or treating pain by using same, and a method for screening for a pain-relieving substance. It has been confirmed that pain can be relieved by regulating the cerebellum, whose role in pain has not been known so far, by using the pharmaceutical composition and the method for relieving pain, according to the present invention. Therefore, the cerebellum can be used as a new treatment target for pain relief through the pharmaceutical composition and the method for relieving pain, according to the present invention. It has also been confirmed that, even when the cerebellum is used as a target for pain according to the present invention, there is no impact on motor function. Thus, the pharmaceutical composition and the method can be effectively used in practice in relieving or treating pain.
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Inventors:
KIM SANG JEONG (KR)
KIM SUN KWANG (KR)
KIM SEUNG HA (KR)
KIM SUN KWANG (KR)
KIM SEUNG HA (KR)
Application Number:
PCT/KR2022/020234
Publication Date:
June 22, 2023
Filing Date:
December 13, 2022
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
UNIV INDUSTRY COOPERATION GROUP KYUNG HEE UNIV (KR)
UNIV INDUSTRY COOPERATION GROUP KYUNG HEE UNIV (KR)
International Classes:
A61K48/00; A61K31/42; A61K31/517; A61K31/7105; A61P25/04; A61P29/00; G01N33/50
Foreign References:
| US6009875A | 2000-01-04 | |||
| KR20110125424A | 2011-11-21 | |||
| KR20160087170A | 2016-07-21 |
Other References:
MARJAN HOSSEINI, ZOHREH KARAMI, ATOUSA JANZADEH, SEYED BEHNAMEDIN JAMEIE, ZAHRA HAJI MASHADI, MAHMOUD YOUSEFIFARD, FARINAZ NASIRIN: "The Effect of Intrathecal Administration of Muscimol on Modulation of Neuropathic Pain Symptoms Resulting from Spinal Cord Injury; an Experimental Study", ARCHIVES OF ACADEMIC EMERGENCY MEDICINE, SHAHID BEHESHTI UNIVERSITY OF MEDICAL SCIENCES, vol. 2, no. 4, 1 December 2018 (2018-12-01), pages 151 - 157, XP093071991, DOI: 10.22037/aaem.v2i4.127
DATABASE Nucleotide 21 September 2020 (2020-09-21), ANONYMOUS : "PREDICTED: Mus musculus adrenergic receptor, alpha 1a (Adra1a), transc -Nucleotide -NCBI", XP093071990, retrieved from NCBI Database accession no. XM_017315802.2
KIM SEUNG HA, LEE JAEGEON, ROH SEUNG-EON, JANG MIRAE, KIM SOOBIN, LEE JI HWAN, SEO JEWOO, HWANG JAE YOON, LEE YONG-SEOK, SHIGETOMI: "Cerebellar Bergmann Glia Integrating Noxious Information Modulate Nocifensive Behaviors", BIORXIV, 20 December 2022 (2022-12-20), pages 1 - 39, XP093071992, Retrieved from the Internet [retrieved on 20230808], DOI: 10.1101/2022.05.18.489807
DATABASE Nucleotide 21 September 2020 (2020-09-21), ANONYMOUS : "PREDICTED: Mus musculus adrenergic receptor, alpha 1a (Adra1a), transc -Nucleotide -NCBI", XP093071990, retrieved from NCBI Database accession no. XM_017315802.2
KIM SEUNG HA, LEE JAEGEON, ROH SEUNG-EON, JANG MIRAE, KIM SOOBIN, LEE JI HWAN, SEO JEWOO, HWANG JAE YOON, LEE YONG-SEOK, SHIGETOMI: "Cerebellar Bergmann Glia Integrating Noxious Information Modulate Nocifensive Behaviors", BIORXIV, 20 December 2022 (2022-12-20), pages 1 - 39, XP093071992, Retrieved from the Internet
Attorney, Agent or Firm:
ERUUM & LEEON INTELLECTUAL PROPERTY LAW FIRM (KR)
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