Title:
PHARMACEUTICAL COMPOSITION FOR TREATING ALLERGY
Document Type and Number:
WIPO Patent Application WO/2022/162992
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a new pharmaceutical composition that can treat a T cell-independent reaction or an early phase reaction (a symptom in an early phase) of an allergic disease. Examples of the present invention include a pharmaceutical composition that contains tacrolimus in an effective amount and that is for treating a T cell-independent allergic disease and/or symptom, a pharmaceutical composition for treating a T cell-independent allergic disease and/or symptom in which ILC2s are activated, and a pharmaceutical composition for treating a T cell-independent allergic disease and/or symptom in which the release and/or production of IL-33 is increased. The present invention can be used for treating an early phase reaction (reaction in an early phase) of an allergic disease and/or symptom or a T cell-independent allergic disease and/or symptom. The present invention is also useful as an ILC2 inactivating agent and an IL-33 inhibitor.
Inventors:
MUKOYAMA YOHEI (JP)
MORIMOTO HIROSHI (JP)
KUBO MASATO (JP)
MORIMOTO HIROSHI (JP)
KUBO MASATO (JP)
Application Number:
PCT/JP2021/032406
Publication Date:
August 04, 2022
Filing Date:
September 03, 2021
Export Citation:
Assignee:
MARUHO KK (JP)
RIKEN (JP)
RIKEN (JP)
International Classes:
A61K31/706; A61K9/08; A61K9/10; A61K9/12; A61K9/14; A61K9/16; A61K9/20; A61K9/48; A61K9/72; A61K31/137; A61K31/40; A61K31/439; A61K31/46; A61K31/4704; A61K31/573; A61K39/395; A61P11/06; A61P37/08; A61P43/00; C07D207/12; C07D215/26; C07D451/10; C07D453/02; C07D471/20; C07H15/04; C07J5/00
Foreign References:
| JPH03291225A | 1991-12-20 |
Other References:
HAMASAKI YUHEI: "Degranulation inhibitory effect of cyclosporin D (CSD) -comparison with other immunosuppressive agents/anti-inflammatory agents", JAPANESE JOURNAL OF PEDIATRIC ALLERGY AND CLINICAL IMMUNOLOGY, vol. 14, no. 2, 1 June 2000 (2000-06-01), Tokyo , pages 182 - 188, XP055954120, ISSN: 0914-2649, DOI: 10.3388/jspaci.14.182
CAI TING; QIU JINXIN; JI YAN; LI WENJING; DING ZHAOYUN; SUO CAIXIA; CHANG JIALI; WANG JINGJING; HE RUI; QIAN YOUCUN; GUO XIAOHUAN;: "IL-17-producing ST2+group 2 innate lymphoid cells play a pathogenic role in lung inflammation", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 143, no. 1, 1 January 2019 (2019-01-01), AMSTERDAM, NL , pages 229 - 224, XP085572588, ISSN: 0091-6749, DOI: 10.1016/j.jaci.2018.03.007
CAI TING; QIU JINXIN; JI YAN; LI WENJING; DING ZHAOYUN; SUO CAIXIA; CHANG JIALI; WANG JINGJING; HE RUI; QIAN YOUCUN; GUO XIAOHUAN;: "IL-17-producing ST2+group 2 innate lymphoid cells play a pathogenic role in lung inflammation", JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, vol. 143, no. 1, 1 January 2019 (2019-01-01), AMSTERDAM, NL , pages 229 - 224, XP085572588, ISSN: 0091-6749, DOI: 10.1016/j.jaci.2018.03.007
Attorney, Agent or Firm:
SHIMIZU Naoto (JP)
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