Title:
PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING NEUROLOGICAL DISORDERS CAUSED BY ALCOHOL EXPOSURE DURING PREGNANCY, CONTAINING METFORMIN AND/OR THYMOQUINONE
Document Type and Number:
WIPO Patent Application WO/2013/172537
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition for treating or preventing neurological disorders caused by alcohol exposure during pregnancy, and a dietary supplement for alleviating or preventing neurological disorders caused by alcohol exposure during pregnancy, containing metformin or a pharmaceutically acceptable salt thereof. In addition, the present invention comprises the composition further containing thymoquinone or a pharmaceutically acceptable salt thereof, and the dietary supplement further containing thymoquinone or a pharmaceutically acceptable salt thereof. The composition and the dietary supplement of the present protects the nerves of a fetus who is expected to have neurological disorders caused by alcohol intake by a mother, thereby preventing or treating neurological disorders caused by alcohol exposure of a fetus.
Inventors:
KIM MYEONG OK (KR)
PARK MOON SEOK (KR)
KIM TAE HYUN (KR)
LEE HAE YOUNG (KR)
PARK MOON SEOK (KR)
KIM TAE HYUN (KR)
LEE HAE YOUNG (KR)
Application Number:
PCT/KR2013/000485
Publication Date:
November 21, 2013
Filing Date:
January 21, 2013
Export Citation:
Assignee:
NAT UNIV GYEONGSANG IACF (KR)
International Classes:
A61K31/155; A61K31/122; A61P25/00
Foreign References:
| US20080188457A1 | 2008-08-07 | |||
| KR101071684B1 | 2011-10-11 |
Other References:
ULLAH, I. ET AL.: "Neuroprotection with metformin and thymoquinone against ethanol- induced apoptotic neurodegeneration in prenatal rat cortical neurons", BMC NEUROSCIENCE, vol. 13, no. 11., January 2012 (2012-01-01)
EL-MIR, M. -Y. ET AL.: "Neuroprotective role of antidiabetic drug metformin against apoptotic cell death in primary cortical neurons", J. MOL. NEUROSCI., vol. 34, 2008, pages 77 - 87
AL-MAJED, A. A. ET AL.: "Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 543, 2006, pages 40 - 47
LI, J. ET AL.: "Effects of metformin in experimental stroke", STROKE, vol. 41, 2010, pages 2645 - 2652
EL-MIR, M. -Y. ET AL.: "Neuroprotective role of antidiabetic drug metformin against apoptotic cell death in primary cortical neurons", J. MOL. NEUROSCI., vol. 34, 2008, pages 77 - 87
AL-MAJED, A. A. ET AL.: "Neuroprotective effects of thymoquinone against transient forebrain ischemia in the rat hippocampus", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 543, 2006, pages 40 - 47
LI, J. ET AL.: "Effects of metformin in experimental stroke", STROKE, vol. 41, 2010, pages 2645 - 2652
Attorney, Agent or Firm:
SON, MIN (KR)
손민 (KR)
손민 (KR)
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