Title:
PHARMACEUTICAL COMPOSITION FOR TREATING AND RESISTING BLOOD COAGULATION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/241688
Kind Code:
A1
Abstract:
The present invention relates to a composition for treating and resisting blood coagulation and use thereof, and particularly relates to a pharmaceutical composition containing (7aS, 2'S)-2-oxo-clopidogrel and use thereof. The present invention provides a medicinal specification of a solid preparation which, after oral administration before/after meals for use in healthy adults, can be similar to clopidogrel bisulfate tablets that are 12.5 times larger in specification in terms of Cmax, AUC(0-t), and AUC(0-∞) of a metabolically produced compound A and an active metabolite H4, thereby ensuring the effectiveness and safety of usage of medication.
Inventors:
ZHANG HAI (CN)
NIE YU (CN)
MOU XIA (CN)
SU YONGWEN (CN)
YI ZEQIN (CN)
NIE YU (CN)
MOU XIA (CN)
SU YONGWEN (CN)
YI ZEQIN (CN)
Application Number:
PCT/CN2023/100638
Publication Date:
December 21, 2023
Filing Date:
June 16, 2023
Export Citation:
Assignee:
CHENGDU SHIBEIKANG BIOMEDICAL TECH CO LTD (CN)
International Classes:
A61K9/20; A61K31/4365; A61P7/02; A61P9/10; A61P25/00
Domestic Patent References:
| WO2021070200A2 | 2021-04-15 |
Foreign References:
| CN115518066A | 2022-12-27 | |||
| CN112076190A | 2020-12-15 | |||
| CN101653420A | 2010-02-24 | |||
| CN101212954A | 2008-07-02 | |||
| CN103068383A | 2013-04-24 | |||
| CN111150731A | 2020-05-15 | |||
| CN111166745A | 2020-05-19 |
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