PHARMACEUTICAL COMPOSITION FOR TREATING SEVERE COMPLEX IMMUNODEFICIENCY COMPRISING FUSION PROTEIN OF CELL PENETRATING PEPTIDE AND ADENOSINE DEAMINASE

Title:

PHARMACEUTICAL COMPOSITION FOR TREATING SEVERE COMPLEX IMMUNODEFICIENCY COMPRISING FUSION PROTEIN OF CELL PENETRATING PEPTIDE AND ADENOSINE DEAMINASE

Document Type and Number:

WIPO Patent Application WO/2019/240429

Kind Code:

A1

Abstract:

The present invention relates to a composition comprising, as an active ingredient, a fusion protein of a cell penetrating peptide and adenosine deaminase, wherein the composition can be efficiently used for treating severe complex immunodeficiency due to the increased cell permeability of adenosine deaminase.

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Inventors:

JI EUN HYE (KR)
AHN GEON YOUNG (KR)
BAEK YI YONG (KR)
CHOI JUN SUB (KR)
KOO HYE CHEONG (KR)

Application Number:

PCT/KR2019/006847

Publication Date:

December 19, 2019

Filing Date:

June 07, 2019

Export Citation:

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Assignee:

AVIXGEN INC (KR)

International Classes:

C12N9/78; A61K38/50; A61K47/64; A61P37/02

Foreign References:

KR101813560B1	2018-01-31
KR20170002475A	2017-01-06
KR20080057751A	2008-06-25
US9796981B2	2017-10-24

Other References:

QI, X. ET AL.: "Cell -penetrating peptides derived from viral capsid proteins", MOLECULAR PLANT-MICROBE INTERACTIONS, vol. 24, no. 1, 2011, pages 25 - 36, XP055669148, ISSN: 0894-0282, DOI: 10.1094/MPMI-07-10-0147
KEMPF, N. ET AL.: "The HIV-1 nucleocapsid protein recruits negatively charged lipids to ensure its optimal binding to lipid membranes", JOURNAL OF VIROLOGY, vol. 89, no. 3, February 2015 (2015-02-01), pages 1756 - 1767, XP055669154, ISSN: 0022-538X, DOI: 10.1128/JVI.02931-14

Attorney, Agent or Firm:

PCR INTELLECTUAL PROPERTY LAW FIRM (KR)

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