Title:
PHARMACEUTICAL COMPOSITION FOR TREATING SKIN OR VASCULAR TISSUE DAMAGE AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/199416
Kind Code:
A1
Abstract:
The present invention relates to: a therapeutic pharmaceutical composition containing spheroids for a diseased area transplant, the composition being used to improve the treatment effect in the treatment of skin or vascular tissue damage by using an LED light source to irradiate a red-wavelength band light; and a method for treating skin or vascular tissue damage using the same. Further, the present invention relates to a method for differentiating mesenchymal stem cells using a red-wavelength band light. The pharmaceutical composition of the present invention can induce the regeneration of the damaged vessel or skin in vivo, and thus can be widely utilized for the treatment of vessel damage, skin ulcers, or wounds. The differentiation method of the present invention can induce the differentiation of stem cells into vascular endothelial cells, even without using a differentiation inducer, and thus can be widely utilized in the development of more economical therapeutic agents for vascular diseases.
Inventors:
PARK IN SU (KR)
AHN JIN CHUL (KR)
CHUNG PIL SANG (KR)
AHN JIN CHUL (KR)
CHUNG PIL SANG (KR)
Application Number:
PCT/KR2015/006371
Publication Date:
December 30, 2015
Filing Date:
June 23, 2015
Export Citation:
Assignee:
UNIV DANKOOK CHEONAN CAMPUS IND ACADEMIC COOPERATION FOUNDATION (KR)
International Classes:
A61K35/35; A61K31/56; A61P17/00; A61P17/02; C12N5/0775; C12N13/00
Foreign References:
| US20120219572A1 | 2012-08-30 | |||
| KR20080091832A | 2008-10-14 |
Other References:
PARK, IN SU: "A novel three-dimensional adipose-derived stem cell cluster for vascular regeneration in ischemic tissue", CYTOTHERAPY, vol. 16, no. 4, April 2014 (2014-04-01), pages 508 - 522, XP055597391, DOI: 10.1016/j.jcyt.2013.08.011
BARBOZA ET AL., LOW-LEVEL LASER IRRADIATION INDUCES IN VITRO PROLIFERATION OF MESENCHYMAL STEM CELLS, vol. 12, no. 1, March 2014 (2014-03-01), Sao Paulo, pages 75 - 81, XP055597405
CHENG, NAI-CHEN ET AL.: "Short-Term Spheroid Formation Enhances the Regenerative Capacity of Adipose-Derived Stem Cells by Promoting Sternness, Angiogenesis, and Chemotaxis", STEM CELLS TRANSLATIONAL MEDICINE, vol. 2, no. 8, 1 August 2013 (2013-08-01), pages 584 - 594, XP055340340
PARK, IN - SU: "Enhancement of Ischemic Wound Healing by Spheroid Grafting of Human Adipose-Derived Stem Cells Treated with Low-Level Light Irradiation", PLOS ONE, vol. 10, no. 6, e0122776, 11 June 2015 (2015-06-11), pages 1 - 16, XP055597454
BARBOZA ET AL., LOW-LEVEL LASER IRRADIATION INDUCES IN VITRO PROLIFERATION OF MESENCHYMAL STEM CELLS, vol. 12, no. 1, March 2014 (2014-03-01), Sao Paulo, pages 75 - 81, XP055597405
CHENG, NAI-CHEN ET AL.: "Short-Term Spheroid Formation Enhances the Regenerative Capacity of Adipose-Derived Stem Cells by Promoting Sternness, Angiogenesis, and Chemotaxis", STEM CELLS TRANSLATIONAL MEDICINE, vol. 2, no. 8, 1 August 2013 (2013-08-01), pages 584 - 594, XP055340340
PARK, IN - SU: "Enhancement of Ischemic Wound Healing by Spheroid Grafting of Human Adipose-Derived Stem Cells Treated with Low-Level Light Irradiation", PLOS ONE, vol. 10, no. 6, e0122776, 11 June 2015 (2015-06-11), pages 1 - 16, XP055597454
Attorney, Agent or Firm:
SON, MIN (KR)
손민 (KR)
손민 (KR)
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