Title:
PHARMACEUTICAL COMPOSITION FOR TREATMENT OF DEMYELINATING DISEASES CONTAINING SUPERNATANT OF IMMORTALIZED MESENCHYMAL STEM CELLS, AND PHARMACEUTICAL PREPARATION CONTAINING SAME COMPOSITION AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2023/167243
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a therapeutic agent for demyelinating diseases in which a culture supernatant of immortalized mesenchymal stem cells into which specific genes are incorporated serves as an active ingredient. Provided is a therapeutic agent for demyelinating diseases in which a culture supernatant of immortalized mesenchymal stem cells into which either the hTERT or pTERT gene and the bmi-1 gene, the HPV-E6 gene, and the HPV-E7 gene are incorporated serves as an active ingredient. The mesenchymal stem cells are preferably of human or porcine origin, and the culture supernatant is preferably obtained by culturing the mesenchymal stem cells for 24-96 hours and contains a component that acts on the receptor c-MET of hepatocyte growth factor (HGF).
Inventors:
YOSHIMOTO TAKAYUKI (JP)
HASEGAWA HIDEAKI (JP)
MIZOGUCHI IZURU (JP)
YAMASHITA YASUHIRO (JP)
HASEGAWA HIDEAKI (JP)
MIZOGUCHI IZURU (JP)
YAMASHITA YASUHIRO (JP)
Application Number:
PCT/JP2023/007619
Publication Date:
September 07, 2023
Filing Date:
March 01, 2023
Export Citation:
Assignee:
UNIV TOKYO MEDICAL (JP)
CYSAY INC (JP)
CYSAY INC (JP)
International Classes:
A61P25/02; A61K35/28; A61P25/28; C12N5/0775; C12N5/10; C12N15/12; C12N15/37; C12N15/54; C12N15/86
Domestic Patent References:
| WO2014126176A1 | 2014-08-21 | |||
| WO2017078176A1 | 2017-05-11 | |||
| WO2015111712A1 | 2015-07-30 |
Other References:
CHIAKI SHIMOJIMA, ET AL.: "Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorates Experimental Autoimmune Encephalomyelitis", THE JOURNAL OF IMMUNOLOGY, WILLIAMS & WILKINS CO., US, vol. 196, no. 10, 15 May 2016 (2016-05-15), US , pages 4164 - 4171, XP055603828, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1501457
YAMAMOTO, AKIHITO ET AL. : "Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorntes Experimental Autoimmune Encephalomyelitis", BIO INDUSTRY, CMC, TOKYO,, JP, vol. 34, no. 3, 1 March 2017 (2017-03-01), JP , pages 70 - 77, XP009548840, ISSN: 0910-6545
ASHIBA KEISUKE, TERUNUMA ATSUSHI, TERUNUMA HIROSHI, TAKANE TSUBASA, DENG XUEWEN, YAMASHITA YASUHIRO, WATANABE KAZUO, : "Mini Review Immortalized mesenchymal stem cells Mini Review Immortalized mesenchymal stem cells producing conditioned medium in a large scale for therapeutic usage", INFLAMMATION AND REGENERATION, vol. 35, no. 2, 1 March 2015 (2015-03-01), pages 57 - 60, XP093088978
SUGIMURA, YUKIKO AND 7 OTHERS: "P-2-098 Possibility of peripheral nerve regeneration treatment using humoral factors derived from deciduous tooth pulp stem cells", REGENERATIVE MEDICINE, JAPANESE SOCIETY FOR REGENERATIVE MEDICINE, JP, vol. 13, no. Suppl., 1 January 2014 (2014-01-01), JP , pages 333, XP009549402, ISSN: 1347-7919
YAMAMOTO, AKIHITO ET AL. : "Conditioned Medium from the Stem Cells of Human Exfoliated Deciduous Teeth Ameliorntes Experimental Autoimmune Encephalomyelitis", BIO INDUSTRY, CMC, TOKYO,, JP, vol. 34, no. 3, 1 March 2017 (2017-03-01), JP , pages 70 - 77, XP009548840, ISSN: 0910-6545
ASHIBA KEISUKE, TERUNUMA ATSUSHI, TERUNUMA HIROSHI, TAKANE TSUBASA, DENG XUEWEN, YAMASHITA YASUHIRO, WATANABE KAZUO, : "Mini Review Immortalized mesenchymal stem cells Mini Review Immortalized mesenchymal stem cells producing conditioned medium in a large scale for therapeutic usage", INFLAMMATION AND REGENERATION, vol. 35, no. 2, 1 March 2015 (2015-03-01), pages 57 - 60, XP093088978
SUGIMURA, YUKIKO AND 7 OTHERS: "P-2-098 Possibility of peripheral nerve regeneration treatment using humoral factors derived from deciduous tooth pulp stem cells", REGENERATIVE MEDICINE, JAPANESE SOCIETY FOR REGENERATIVE MEDICINE, JP, vol. 13, no. Suppl., 1 January 2014 (2014-01-01), JP , pages 333, XP009549402, ISSN: 1347-7919
Attorney, Agent or Firm:
AYAFUNE INTERNATIONAL PATENTS & TRADEMARKS PATENT PROFESSIONAL CORPORATION (JP)
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