Title:
PHARMACEUTICAL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2023/246247
Kind Code:
A1
Abstract:
The present invention relates to a pharmaceutical composition, comprising an anti-CD73 (for example, human CD73) antibody or an antigen-binding fragment thereof, and an anti-PD-1-anti-VEGFA bispecific antibody or an antigen-binding fragment thereof. Specifically, a heavy chain variable region of the anti-CD73 antibody comprises HCDR1-HCDR3 with amino acid sequences shown in SEQ ID NOs: 15-17; and a light chain variable region of the antibody comprises LCDR1-LCDR3 with amino acid sequences shown in SEQ ID NOs: 18-20.
Inventors:
LI BAIYONG (CN)
XIA YU (CN)
WANG ZHONGMIN (CN)
XIA YU (CN)
WANG ZHONGMIN (CN)
Application Number:
PCT/CN2023/087998
Publication Date:
December 28, 2023
Filing Date:
April 13, 2023
Export Citation:
Assignee:
AKESO BIOPHARMA INC (CN)
International Classes:
C07K16/46; A61K39/395; A61P7/06; A61P35/00; C07K16/28; C07K16/40; C12N5/20; C12N15/13
Domestic Patent References:
| WO2017019896A1 | 2017-02-02 | |||
| WO2019173692A2 | 2019-09-12 |
Foreign References:
| CN113527501A | 2021-10-22 | |||
| CN113214400A | 2021-08-06 | |||
| CN110498857A | 2019-11-26 | |||
| CN111712522A | 2020-09-25 | |||
| CN113527489A | 2021-10-22 | |||
| CN110960543A | 2020-04-07 | |||
| US5747654A | 1998-05-05 | |||
| US4816567A | 1989-03-28 | |||
| CN112830972A | 2021-05-25 |
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CHOTHIALESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
CHOTHIA ET AL., NATURE, vol. 342, 1989, pages 878 - 883
EHRENMANN, FRANCOISQUENTIN KAASMARIE-PAULE LEFRANC.: "IMGT/3Dstructure-DB and IMGT/DomainGapAlign: a database and a tool for immunoglobulins or antibodies, T cell receptors, MHC, IgSF and MhcSF", NUCLEIC ACIDS RESEARCH, vol. 38, 2009
KOHLER GMILSTEIN C.: "Continuous cultures of fused cells secreting antibody of predefined specificity [J", NATURE, vol. 256, no. 5517, 1975, pages 495, XP037052082, DOI: 10.1038/256495a0
JONES ET AL., NATURE, vol. 321, 1986, pages 522 - 525
REICHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 329
PRESTA, CURR. OP. STRUCT. BIOL., vol. 2, 1992, pages 593 - 596
CLARK M.: "Antibody humanization: a case of the ''Emperor's new clothes'' [J", IMMUNOL. TODAY, vol. 21, no. 8, 2000, pages 397 - 402, XP004215168, DOI: 10.1016/S0167-5699(00)01680-7
"Remington's Pharmaceutical Sciences", 1995, MACK PUBLISHING COMPANY
ACIERNO ET AL.: "Affinity maturation increases the stability and plasticity of the Fv domain of anti-protein antibodies", J MOL BIOL., vol. 374, no. 1, 2007, pages 130 - 146, XP022310713, DOI: 10.1016/j.jmb.2007.09.005
HAGE TREINEMER PSEBALD W.: "Crystals of a 1:1 complex between human interleukin-4 and the extracellular domain of its receptor alpha chain", EURJ BIOCHEM., vol. 258, no. 2, 1998, pages 831 - 6, XP003018346, DOI: 10.1046/j.1432-1327.1998.2580831.x
SYNNESTVEDT K ET AL., J CLIN INVEST., vol. 110, 2002, pages 993 - 1002
ANTONIOLI L ET AL., NAT REV CANCER, vol. 13, 2013, pages 842 - 857
JULIE R ET AL., N ENGL J MED., vol. 366, 2012, pages 2455 - 2465
HAMANISHI ET AL., PROC. NATL. ACAD. SCI. USA, vol. 104, 2007, pages 3360 - 5
HOMET M. B.PARISI G. ET AL., SEMIN ONCOL., vol. 42, no. 3, 2015, pages 466 - 473
HELD SAHEINE A ET AL., CURR CANCER DRUG TARGETS., vol. 13, no. 7, 2013, pages 768 - 74
MA LI, CHINESE JOURNAL OF BIRTH HEALTH AND HEREDITY, vol. 24, no. 5, 2016, pages 146 - 148
ROSKOSKI R JR ET AL., CRIT REV ONCOL HEMATOL, vol. 62, no. 3, 2007, pages 179 - 213
TAKAHASHI T ET AL., ONCOGENE, vol. 18, no. 13, 1999, pages 2221 - 2230
DONG HONGCHAO ET AL., JOURNAL OF MODERN ONCOLOGY, vol. 22, no. 9, September 2014 (2014-09-01), pages 2231 - 3
KABAT ET AL.: "Sequences of Proteins of Immunological Interest", 1991, NIH PUBLICATION
RAJAGOPAL ET AL., PROT. ENGIN., vol. 10, 1997, pages 1453 - 1459
REITER ET AL., NAT. BIOTECHNOL., vol. 14, 1996, pages 1239 - 1245
REITER ET AL., PROTEIN ENGINEERING, vol. 8, 1995, pages 1323 - 1331
WEBBER ET AL., MOLECULAR IMMUNOLOGY, vol. 32, 1995, pages 249 - 258
REITER ET AL., IMMUNITY, vol. 2, 1995, pages 281 - 287
REITER ET AL., JBC, vol. 269, 1994, pages 18327 - 18331
REITER ET AL., INTER J. OF CANCER, vol. 58, 1994, pages 142 - 149
REITER ET AL., CANCER RES., vol. 54, 1994, pages 2714 - 2718
CHOTHIALESK, J. MOL. BIOL., vol. 196, 1987, pages 901 - 917
CHOTHIA ET AL., NATURE, vol. 342, 1989, pages 878 - 883
EHRENMANN, FRANCOISQUENTIN KAASMARIE-PAULE LEFRANC.: "IMGT/3Dstructure-DB and IMGT/DomainGapAlign: a database and a tool for immunoglobulins or antibodies, T cell receptors, MHC, IgSF and MhcSF", NUCLEIC ACIDS RESEARCH, vol. 38, 2009
KOHLER GMILSTEIN C.: "Continuous cultures of fused cells secreting antibody of predefined specificity [J", NATURE, vol. 256, no. 5517, 1975, pages 495, XP037052082, DOI: 10.1038/256495a0
JONES ET AL., NATURE, vol. 321, 1986, pages 522 - 525
REICHMANN ET AL., NATURE, vol. 332, 1988, pages 323 - 329
PRESTA, CURR. OP. STRUCT. BIOL., vol. 2, 1992, pages 593 - 596
CLARK M.: "Antibody humanization: a case of the ''Emperor's new clothes'' [J", IMMUNOL. TODAY, vol. 21, no. 8, 2000, pages 397 - 402, XP004215168, DOI: 10.1016/S0167-5699(00)01680-7
"Remington's Pharmaceutical Sciences", 1995, MACK PUBLISHING COMPANY
ACIERNO ET AL.: "Affinity maturation increases the stability and plasticity of the Fv domain of anti-protein antibodies", J MOL BIOL., vol. 374, no. 1, 2007, pages 130 - 146, XP022310713, DOI: 10.1016/j.jmb.2007.09.005
HAGE TREINEMER PSEBALD W.: "Crystals of a 1:1 complex between human interleukin-4 and the extracellular domain of its receptor alpha chain", EURJ BIOCHEM., vol. 258, no. 2, 1998, pages 831 - 6, XP003018346, DOI: 10.1046/j.1432-1327.1998.2580831.x
Attorney, Agent or Firm:
BEIJING C & S LAW FIRM (CN)
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