Title:
PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2020/090698
Kind Code:
A1
Abstract:
Provided, as a cancer prophylactic drug or a cancer therapeutic drug, are a compound having the effect of inhibiting DNA methyltransferase (DNMT), and another drug.
Inventors:
SAKO MAGOICHI (JP)
SUGIYAMA SHIMPEI (JP)
KURAHASHI YUKI (JP)
WAKITA HIROO (JP)
KIMURA SHINYA (JP)
WATANABE TATSURO (JP)
URESHINO HIROSHI (JP)
SUGIYAMA SHIMPEI (JP)
KURAHASHI YUKI (JP)
WAKITA HIROO (JP)
KIMURA SHINYA (JP)
WATANABE TATSURO (JP)
URESHINO HIROSHI (JP)
Application Number:
PCT/JP2019/042080
Publication Date:
May 07, 2020
Filing Date:
October 28, 2019
Export Citation:
Assignee:
OHARA PHARMACEUTICAL CO LTD (JP)
UNIV SAGA (JP)
UNIV SAGA (JP)
International Classes:
A61K45/06; A61K31/165; A61K31/166; A61K31/255; A61K31/405; A61K31/52; A61K31/706; A61K31/7072; A61K31/7076; A61P35/00; A61P35/02; A61P43/00
Domestic Patent References:
| WO2017183217A1 | 2017-10-26 | |||
| WO2019160127A1 | 2019-08-22 |
Other References:
MOMPARLER R. L. ET AL.: "Epigenetic therapy of acute myeloid leukemia using 5-aza-2'-deoxycytidine (decitabine) in combination with inhibitors of histone methylation and deacetylation", CLINICAL EPIGENETICS, vol. 6, no. 1, 2014, pages 1 - 12, XP021200068, DOI: 10.1186/1868-7083-6-19
YAN, P. ET AL.: "Human I- cell leukemia virus type I-mediated repression of PDZ-LIM domain-containing protein 2 involves DNA methylation but independent of the viral oncoprotein tax", NEOPLASIA, vol. 11, no. 10, 2009, pages 1036 - 1041, XP055634577, DOI: 10.1593/neo.09752
FUJIKAWA, D. ET AL.: "Polycomb-dependent epigenetic landscape in adult I- cell leukemia", BLOOD, vol. 127, no. 14, 2016, pages 1790 - 1802, XP055704354
NISHIOKA, C. ET AL.: "Histone deacetylase inhibitors induce growth arrest and apoptosis of HTLV-1-infected I-cells via blockade of signaling by nuclear factor kappaB", LEUKEMIA RESEARCH, vol. 32, no. 2, 2008, pages 287 - 296, XP022477409, DOI: 10.1016/j.leukres.2007.05.026
YAN, P. ET AL.: "Human I- cell leukemia virus type I-mediated repression of PDZ-LIM domain-containing protein 2 involves DNA methylation but independent of the viral oncoprotein tax", NEOPLASIA, vol. 11, no. 10, 2009, pages 1036 - 1041, XP055634577, DOI: 10.1593/neo.09752
FUJIKAWA, D. ET AL.: "Polycomb-dependent epigenetic landscape in adult I- cell leukemia", BLOOD, vol. 127, no. 14, 2016, pages 1790 - 1802, XP055704354
NISHIOKA, C. ET AL.: "Histone deacetylase inhibitors induce growth arrest and apoptosis of HTLV-1-infected I-cells via blockade of signaling by nuclear factor kappaB", LEUKEMIA RESEARCH, vol. 32, no. 2, 2008, pages 287 - 296, XP022477409, DOI: 10.1016/j.leukres.2007.05.026
Attorney, Agent or Firm:
Sha Patent and Trademark Firm (JP)
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