Title:
PHARMACEUTICAL COMPOSITION
Document Type and Number:
WIPO Patent Application WO/2022/154044
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a pharmaceutical composition for therapeutic use that is efficacious against pancreatic cancer. This problem can be solved by the pharmaceutical composition according to the present invention that comprises a fibroblast growth factor receptor 4 inhibitor and a senescent cell death inducer as active ingredients.
More Like This:
Inventors:
ISHIWATA TOSHIYUKI (JP)
SASAKI NORIHIKO (JP)
SASAKI NORIHIKO (JP)
Application Number:
PCT/JP2022/000890
Publication Date:
July 21, 2022
Filing Date:
January 13, 2022
Export Citation:
Assignee:
TOKYO METROPOLITAN GERIATRIC HOSPITAL AND INST OF GERONTOLOGY (JP)
International Classes:
A61K45/06; A61K31/352; A61K31/496; A61K31/517; A61K39/395; A61K47/68; A61P1/16; A61P35/00; A61P43/00
Domestic Patent References:
| WO2020063788A1 | 2020-04-02 |
Other References:
TOSHIYUKI ISHIWATARI, HISASHI YOSHIMURA, YOKO MATSUDA, TAEKO SUZUKI, YOKO KAWAMOTO, KIYOKO KAWAHARA, SHUNJI ISHIWATARI, AKIRA MATS: "Expression of fibroblast growth factor receptor (FGFR-4) in pancreas cancer, and its feasibility as therapeutic target", SUIZO - JAPAN PANCREAS SOCIETY. JOURNAL, NIHON SUIZO GAKKAI, SENDAI, JP, vol. 30, no. 3, 1 January 2015 (2015-01-01), JP , pages 352 (PCA1), XP009538339, ISSN: 0913-0071
GUO YANGYANG; TONG YU; ZHU HENGYUE; XIAO YANYI; GUO HANGCHENG; SHANG LUMENG; ZHENG WENJING; MA SHUMEI; LIU XIAODONG; BAI YONGHENG: "Quercetin suppresses pancreatic ductal adenocarcinoma progression via inhibition of SHH and TGF-β/Smad signaling pathways", CELL BIOLOGY AND TOXICOLOGY., SPRINGER NETHERLANDS, NL, vol. 37, no. 3, 17 October 2020 (2020-10-17), NL , pages 479 - 496, XP037466855, ISSN: 0742-2091, DOI: 10.1007/s10565-020-09562-0
PHAM THAO N.D., STEMPEL SOPHIE, SHIELDS MARIO A., SPAULDING CHRISTINA, KUMAR KRISHAN, BENTREM DAVID J., MATSANGOU MARIA, MUNSHI HI: "Quercetin Enhances the Anti-Tumor Effects of BET Inhibitors by Suppressing hnRNPA1", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, no. 17, 2 September 2019 (2019-09-02), pages 4293, XP055950067, DOI: 10.3390/ijms20174293
PANG BING, XU XIAOGUANG, LU YAO, JIN HAN, YANG RONGRONG, JIANG CHUNMEI, SHAO DONGYAN, LIU YANLIN, SHI JUNLING: "Prediction of new targets and mechanisms for quercetin in the treatment of pancreatic cancer, colon cancer, and rectal cancer", FOOD & FUNCTION, R S C PUBLICATIONS, GB, vol. 10, no. 9, 18 September 2019 (2019-09-18), GB , pages 5339 - 5349, XP055950069, ISSN: 2042-6496, DOI: 10.1039/C9FO01168D
SASAKI NORIHIKO, GOMI FUJIYA, YOSHIMURA HISASHI, YAMAMOTO MASAMI, MATSUDA YOKO, MICHISHITA MASAKI, HATAKEYAMA HITOSHI, KAWANO YOIC: "FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Proliferation and Invasion While Inducing Senescence: Evidence for Senolytic Therapy Potential in Pancreatic Cancer", CANCERS, vol. 12, no. 10, 14 October 2020 (2020-10-14), pages 2976, XP055950071, DOI: 10.3390/cancers12102976
NAITO: "Overexpression of fibroblast growth factor receptor 4 in high-grade pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma", INTERNATIONAL JOURNAL OF ONCOLOGY, DEMETRIOS A. SPANDIDOS ED. & PUB, GR, vol. 38, no. 1, 24 November 2010 (2010-11-24), GR , XP055950073, ISSN: 1019-6439, DOI: 10.3892/ijo_00000832
GUO YANGYANG; TONG YU; ZHU HENGYUE; XIAO YANYI; GUO HANGCHENG; SHANG LUMENG; ZHENG WENJING; MA SHUMEI; LIU XIAODONG; BAI YONGHENG: "Quercetin suppresses pancreatic ductal adenocarcinoma progression via inhibition of SHH and TGF-β/Smad signaling pathways", CELL BIOLOGY AND TOXICOLOGY., SPRINGER NETHERLANDS, NL, vol. 37, no. 3, 17 October 2020 (2020-10-17), NL , pages 479 - 496, XP037466855, ISSN: 0742-2091, DOI: 10.1007/s10565-020-09562-0
PHAM THAO N.D., STEMPEL SOPHIE, SHIELDS MARIO A., SPAULDING CHRISTINA, KUMAR KRISHAN, BENTREM DAVID J., MATSANGOU MARIA, MUNSHI HI: "Quercetin Enhances the Anti-Tumor Effects of BET Inhibitors by Suppressing hnRNPA1", INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, vol. 20, no. 17, 2 September 2019 (2019-09-02), pages 4293, XP055950067, DOI: 10.3390/ijms20174293
PANG BING, XU XIAOGUANG, LU YAO, JIN HAN, YANG RONGRONG, JIANG CHUNMEI, SHAO DONGYAN, LIU YANLIN, SHI JUNLING: "Prediction of new targets and mechanisms for quercetin in the treatment of pancreatic cancer, colon cancer, and rectal cancer", FOOD & FUNCTION, R S C PUBLICATIONS, GB, vol. 10, no. 9, 18 September 2019 (2019-09-18), GB , pages 5339 - 5349, XP055950069, ISSN: 2042-6496, DOI: 10.1039/C9FO01168D
SASAKI NORIHIKO, GOMI FUJIYA, YOSHIMURA HISASHI, YAMAMOTO MASAMI, MATSUDA YOKO, MICHISHITA MASAKI, HATAKEYAMA HITOSHI, KAWANO YOIC: "FGFR4 Inhibitor BLU9931 Attenuates Pancreatic Cancer Cell Proliferation and Invasion While Inducing Senescence: Evidence for Senolytic Therapy Potential in Pancreatic Cancer", CANCERS, vol. 12, no. 10, 14 October 2020 (2020-10-14), pages 2976, XP055950071, DOI: 10.3390/cancers12102976
NAITO: "Overexpression of fibroblast growth factor receptor 4 in high-grade pancreatic intraepithelial neoplasia and pancreatic ductal adenocarcinoma", INTERNATIONAL JOURNAL OF ONCOLOGY, DEMETRIOS A. SPANDIDOS ED. & PUB, GR, vol. 38, no. 1, 24 November 2010 (2010-11-24), GR , XP055950073, ISSN: 1019-6439, DOI: 10.3892/ijo_00000832
Attorney, Agent or Firm:
YAMAGUCHI Kenjiro et al. (JP)
Download PDF:
Previous Patent: LINEAR ACTUATOR
Next Patent: METHOD FOR PREDICTING RISK FOR THROMBOSIS IN CANCER PATIENT USING SOLUBLE CLEC2
Next Patent: METHOD FOR PREDICTING RISK FOR THROMBOSIS IN CANCER PATIENT USING SOLUBLE CLEC2