PHARMACEUTICAL COMPOUND

WIPO Patent Application WO/2016/071293

A3

Provided is a tryptophan-2,3-dioxygenase (TDO) and/or indoleamine-2,3-dioxygenase (IDO) inhibitor compound for use in medicine, which compound comprises formula (I) wherein X1, and X2 may be the same or different and each is independently selected from C, N, O and S; X3, X4, X5, and X6 may be the same or different and each is independently selected from C and N; each bond represented by a dotted line may be present or absent, provided that at least one such bond is present; R1, R2, R3, R4, R5 and R6 may be present or absent and may be the same or different and each is independently selected from H and a substituted or unsubstituted organic group, provided that the number of R1, R2, R3, R4, R5 and R6 groups present is such that the respective valencies of X1, X2, X3, X4, X5, and X6 are maintained; and wherein at least one of R5 and R6 comprises a group Y, wherein Y is a group having a formula selected from (II), (III), (IV), (V), (VI), (VII) wherein L may be present or absent, and may be a substituted or unsubstituted organic linking group; R31 and R32 may be the same or different and are selected from H and a substituted or unsubstituted organic group; each R34 may be the same or different and is selected from H and a substituted or unsubstituted organic group; R35 is selected from a substituted or unsubstituted alcohol group or ether group; each R36 may be the same or different and is selected from H and a substituted or unsubstituted organic group; X7 may be selected from C and N; X8, X9, X10, X11, X12, X13, X14, X15 and X16 may be the same or different and each is independently selected from C, N, O and S; each bond represented by a dotted line may be present or absent; and each R313 may be the same or different and is selected from H and a substituted or unsubstituted organic group.

COWLEY PHILLIP (GB)
WISE ALAN (GB)

PCT/EP2015/075486

August 25, 2016

November 02, 2015

Click for automatic bibliography generation  

IOMET PHARMA LTD (GB)

A61K31/4985; A61K31/416; A61K31/438; A61K31/439; A61K31/445; A61K31/4523; A61K31/454; A61K31/496; A61K31/499; A61K31/4995; A61P9/00; A61P25/00; A61P27/12; A61P31/00; A61P35/00; A61P37/00; A61P43/00; C07D231/56; C07D401/14; C07D403/12

WO2013131609A1	2013-09-12
WO2011067366A1	2011-06-09
WO2007038284A1	2007-04-05
WO2005039564A1	2005-05-06
WO2014159248A1	2014-10-02
WO2013130855A1	2013-09-06
WO1998035943A1	1998-08-20

US20030087908A1	2003-05-08
EP1188747A1	2002-03-20
EP0999208A1	2000-05-10
US20070249575A1	2007-10-25
EP1403255A1	2004-03-31
US20020115670A1	2002-08-22
US20050267096A1	2005-12-01
US7759339B2	2010-07-20
US20040106667A1	2004-06-03
US20070167431A1	2007-07-19

CRISTINA GALIANA-ROSELLÓ ET AL: "In Vitro and in Vivo Antileishmanial and Trypanocidal Studies of New N -Benzene- and N -Naphthalenesulfonamide Derivatives", JOURNAL OF MEDICINAL CHEMISTRY, vol. 56, no. 22, 27 November 2013 (2013-11-27), pages 8984 - 8998, XP055101136, ISSN: 0022-2623, DOI: 10.1021/jm4006127
FENG ET AL: "Structure-activity relationships, and drug metabolism and pharmacokinetic properties for indazole piperazine and indazole piperidine inhibitors of ROCK-II", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, AMSTERDAM, NL, vol. 17, no. 8, 30 March 2007 (2007-03-30), pages 2355 - 2360, XP022009265, ISSN: 0960-894X, DOI: 10.1016/J.BMCL.2006.12.043
PAOLO MOMBELLI ET AL: "Identification of 1,3-Diiminoisoindoline Carbohydrazides as Potential Antimalarial Candidates", CHEMMEDCHEM, vol. 7, no. 1, 2 January 2012 (2012-01-02), DE, pages 151 - 158, XP055243129, ISSN: 1860-7179, DOI: 10.1002/cmdc.201100441
EDUARD DOLUŠIC ET AL: "Tryptophan 2,3-Dioxygenase (TDO) Inhibitors. 3-(2-(Pyridyl)ethenyl)indoles as Potential Anticancer Immunomodulators", JOURNAL OF MEDICINAL CHEMISTRY, vol. 54, no. 15, 11 August 2011 (2011-08-11), pages 5320 - 5334, XP055048345, ISSN: 0022-2623, DOI: 10.1021/jm2006782
PERNER R J ET AL: "In vitro Structure-Activity Relationship and in vivo Characterization of 1-(Aryl)-3-(4-(amino)benzyl)urea transient Receptor Potential Vanilloid 1 Antagonists", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 50, no. 15, 1 January 2007 (2007-01-01), pages 3651 - 3660, XP002591492, ISSN: 0022-2623, [retrieved on 20070621], DOI: 10.1021/JM070276I

BUCHAN, Gavin, M. et al. (European Patent DepartmentHertford Roa, Hoddesdon Hertfordshire EN11 9BU, GB)

View/Download PDF      PDF Help

Previous Patent: BEVERAGE DISPENSING APPARATUS AND METHOD

Next Patent: WATER-SOLUBLE CONTAINER AND METHOD FOR THE PRODUCTION THEREOF