Title:
PHARMACEUTICAL FORMULATION FOR TREATING CARDIOVASCULAR DISEASE
Document Type and Number:
WIPO Patent Application WO/2009/127974
Kind Code:
A3
Abstract:
The present invention provides a pharmaceutical formulation comprising: an early release portion comprising as a pharmaceutical active ingredient a statin-based hypolipidic agent, an isomer thereof, or a pharmaceutically acceptable salt thereof; and a slow release portion comprising as a pharmaceutical active ingredient a dihydropyridine-based calcium channel blocking agent, an isomer thereof, or a pharmaceutically acceptable salt thereof. When compared with a single formulation of each of the drugs or a simple combination formulation of the drugs, the pharmaceutical formulation according to the present invention comprising an early release portion comprising a statin-based hypolipidic agent and a slow release portion comprising a dihydropyridine-based calcium channel blocking agent is pharmaceutically, scientifically, and economically very useful in preventing or treating cardiovascular disease, pulmonary heart disease, pulmonary disease, or kidney disease of patients who have a metabolic syndrome, insulin resistance, diabetes, or prediabetes. The formulation of the present invention is effective in preventing antagonistic and side effects between the drugs by making the dissolution rate of the statin-based hypolipidic agent different from that of the dihydropyridine-based calcium channel blocking agent, and in facilitating patient compliance in taking the drugs by administering the two different drugs simultaneously.
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Inventors:
KIM SUNG WUK (KR)
JUN SUNG SOO (KR)
KOO JA SEONG (KR)
KIM JIN WOOK (KR)
PARK SUN WOO (KR)
JANG SEOK YOUNG (KR)
LEE SANG JU (KR)
JO YOUNG GWAN (KR)
LEE JUN YOUNG (KR)
JUN SUNG SOO (KR)
KOO JA SEONG (KR)
KIM JIN WOOK (KR)
PARK SUN WOO (KR)
JANG SEOK YOUNG (KR)
LEE SANG JU (KR)
JO YOUNG GWAN (KR)
LEE JUN YOUNG (KR)
Application Number:
PCT/IB2009/006277
Publication Date:
March 25, 2010
Filing Date:
February 23, 2009
Export Citation:
Assignee:
HANALL PHARMACEUTICAL CO LTD (KR)
KIM SUNG WUK (KR)
JUN SUNG SOO (KR)
KOO JA SEONG (KR)
KIM JIN WOOK (KR)
PARK SUN WOO (KR)
JANG SEOK YOUNG (KR)
LEE SANG JU (KR)
JO YOUNG GWAN (KR)
LEE JUN YOUNG (KR)
KIM SUNG WUK (KR)
JUN SUNG SOO (KR)
KOO JA SEONG (KR)
KIM JIN WOOK (KR)
PARK SUN WOO (KR)
JANG SEOK YOUNG (KR)
LEE SANG JU (KR)
JO YOUNG GWAN (KR)
LEE JUN YOUNG (KR)
International Classes:
A61K9/52; A61K9/22; A61K9/28; A61K31/40; A61K31/44; A61K47/38; A61P9/00; A61P13/12
Foreign References:
| KR20070078625A | 2007-08-01 | |||
| KR20010022385A | 2001-03-15 | |||
| KR20050016452A | 2005-02-21 | |||
| KR100582347B1 | 2006-05-22 |
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