Title:
PHARMACEUTICAL FORMULATIONS OF RHODIOLA CRENULATA AND METHODS OF USE THEREOF
Document Type and Number:
WIPO Patent Application WO2006122274
Kind Code:
A3
Abstract:
Isolated extracts of Rhodiola crenulata and their constituents sensitize tumor cells to cancer therapies, such as tamoxifen, retinoids, and radiation, and act to potentiate radiation therapy in the treatment of cancer, with or without adjuvant chemotherapy. Methods are provided for inhibiting the P13kinase/AKT pathway in cancer cells, a general survival pathway which leads to resistance of many tumors to typical therapies; decreasing cyclooxygenase (COX) activities in cancer cells, another pathway known to increase resistance to tumors; inhibiting telomerase activity in cancer cells, an activity notable for its ability to increase the life span of the cells; enhancing the ATM (Ataxia-Telangiectasia Mutated) response in cells, which is involved in DNA damage sensing and repair; modulating cellular response to oxidation, which effects the other signaling pathways on numerous levels; and altering usage of metabolic energy pathways.
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Inventors:
SCHNEIDER SALLIE SMITH (US)
SHETTY KALIDAS (US)
SHETTY KALIDAS (US)
Application Number:
PCT/US2006/018316
Publication Date:
December 28, 2006
Filing Date:
May 11, 2006
Export Citation:
Assignee:
BAYSTATE HEALTH SYSTEMS INC (US)
UNIV MASSACHUSETTS (US)
SCHNEIDER SALLIE SMITH (US)
SHETTY KALIDAS (US)
UNIV MASSACHUSETTS (US)
SCHNEIDER SALLIE SMITH (US)
SHETTY KALIDAS (US)
International Classes:
A61P35/00; A61K36/41
Domestic Patent References:
| WO2005044182A2 | 2005-05-19 |
Foreign References:
| CN1320440A | 2001-11-07 | |||
| US6399116B1 | 2002-06-04 |
Other References:
HAN X ET AL: "Separation of salidroside from Rhodiola crenulata by high-speed counter-current chromatography", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER, AMSTERDAM, NL, vol. 971, no. 1-2, 20 September 2002 (2002-09-20), pages 237 - 241, XP004380045, ISSN: 0021-9673
PATENT ABSTRACTS OF JAPAN
LEI Y ET AL: "CHEMICAL COMPOSITION OF THE ESSENTIAL OILS OF TWO RHODIOLA SPECIES FROM TIBET", ZEITSCHRIFT FUER NATURFORSCHUNG. C, A JOURNAL OF BIOSCIENCES, TUEBINGEN, DE, vol. 58, no. 3/4, March 2003 (2003-03-01), pages 161 - 164, XP009028826, ISSN: 0939-5075
"Rhodiola rosea", ALTERNATIVE MEDICINE REVIEW 2002 UNITED STATES, vol. 7, no. 5, 2002, pages 421 - 423, XP009073499, ISSN: 1089-5159
PATENT ABSTRACTS OF JAPAN
LEI Y ET AL: "CHEMICAL COMPOSITION OF THE ESSENTIAL OILS OF TWO RHODIOLA SPECIES FROM TIBET", ZEITSCHRIFT FUER NATURFORSCHUNG. C, A JOURNAL OF BIOSCIENCES, TUEBINGEN, DE, vol. 58, no. 3/4, March 2003 (2003-03-01), pages 161 - 164, XP009028826, ISSN: 0939-5075
"Rhodiola rosea", ALTERNATIVE MEDICINE REVIEW 2002 UNITED STATES, vol. 7, no. 5, 2002, pages 421 - 423, XP009073499, ISSN: 1089-5159
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