PHARMACEUTICAL FORMULATIONS TARGETING SPECIFIC REGIONS OF THE GASTROINTESTINAL TRACT

Title:

PHARMACEUTICAL FORMULATIONS TARGETING SPECIFIC REGIONS OF THE GASTROINTESTINAL TRACT

Document Type and Number:

WIPO Patent Application WO2004041195

Kind Code:

A3

Abstract:

Oral formulations of pharmaceuticals are provided with enhanced bioavailability by targeting specific regions of the gastrointestinal tract. Particularly, water soluble and acid-labile drugs such as cytidine analogs (e.g., decitabine) and 2'-deoxyadenosine analogs (e.g., pentostatin) are formulated with pH-sensitive polymers so that these drugs are preferably absorbed in the upper regions of the small intestine, such as the jejunum. In addition, drugs with poor oral bioavailability such as camptothecin compounds (e.g., 9 nitro-camptothecin) can also be formulated using similar strategies in order to significantly improve their oral bioavailability. These formulations can be used to treat a wide variety of diseases or conditions, such hematological disorders, benign tumors, cancer, restenosis, inflammatory diseases, and autoimmune diseases.

Inventors:

SANDS HOWARD (US)
REDKAR SANJEEV (US)
RAVIVARAPU HARISH (US)

Application Number:

PCT/US2003/034781

Publication Date:

August 19, 2004

Filing Date:

October 31, 2003

Export Citation:

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Assignee:

SUPERGEN INC (US)
SANDS HOWARD (US)
REDKAR SANJEEV (US)
RAVIVARAPU HARISH (US)

International Classes:

A61K9/14; A61K9/22; A61K9/24; A61K9/26; A61K9/28; A61K9/30; A61K9/32; A61K9/34; A61K9/40; A61K9/42; A61K31/4745; A61K31/55; A61K31/7052; A61K31/706; A61K31/7064; A61K31/7068; A61K31/7072; A61K31/7076; A61K31/708; A61K; (IPC1-7): A61K9/14; A61K9/22; A61K9/26; A61K9/28; A61K9/32; A61K9/34; A61K9/40; A61K9/42

Foreign References:

US6248363B1

2001-06-19

Other References: