Title:
PHARMACEUTICAL PRODUCT CONTAINING HETEROCYCLIC SULFONAMIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2010/126002
Kind Code:
A1
Abstract:
Disclosed is a compound represented by formula (Ia), a pharmaceutically acceptable salt thereof, or a solvate of the compound or salt, which serves as an agent for treatment of diseases induced by the production, secretion and deposition of amyloid β protein.
(In the formula, X represents -O- or -S-; ring A represents a benzene ring or the like; R1a, R2a and R3a each independently represents a hydrogen atom, a halogen atom, a substituted or unsubstituted alkoxycarbonyl group, a substituted or unsubstituted carbon ring or the like; R4 represents a halogen atom, a hydroxy group, a substituted or unsubstituted alkyl group or the like; R5a represents a substituted or unsubstituted, 5-membered or 6-membered unsaturated heterocyclic group, C(=O)R6 or the like; p represents an integer of 0-2; R6 represents a hydroxy group, a substituted or unsubstituted alkoxy group or the like; La represents -SO2NH-, -C(=O)NH- or the like; and Ak1 and Ak2 each independently represents a single bond or the like.)
Inventors:
NISHITOMI KOUHEI (JP)
KANO KAZUYA (JP)
KATO ISSEI (JP)
SAKO YUSUKE (JP)
KANO KAZUYA (JP)
KATO ISSEI (JP)
SAKO YUSUKE (JP)
Application Number:
PCT/JP2010/057362
Publication Date:
November 04, 2010
Filing Date:
April 26, 2010
Export Citation:
Assignee:
SHIONOGI & CO (JP)
NISHITOMI KOUHEI (JP)
KANO KAZUYA (JP)
KATO ISSEI (JP)
SAKO YUSUKE (JP)
NISHITOMI KOUHEI (JP)
KANO KAZUYA (JP)
KATO ISSEI (JP)
SAKO YUSUKE (JP)
International Classes:
C07D307/68; A61K31/341; A61K31/381; A61K31/40; A61K31/4025; A61K31/404; A61K31/41; A61K31/4155; A61K31/4178; A61K31/4196; A61K31/42; A61K31/422; A61K31/427; A61K31/437; A61K31/4436; A61K31/4439; A61K31/496; A61K31/497; A61K31/506; A61K31/5377; A61K31/541; A61P25/28; A61P43/00; C07D307/64; C07D333/34; C07D333/54; C07D333/62; C07D401/14; C07D409/04; C07D409/12; C07D413/04; C07D413/12; C07D413/14; C07D415/00; C07D417/04; C07D417/14; C07D471/04
Domestic Patent References:
| WO2007071598A1 | 2007-06-28 | |||
| WO2002046171A2 | 2002-06-13 | |||
| WO2005037257A2 | 2005-04-28 | |||
| WO2005090298A1 | 2005-09-29 | |||
| WO1999019303A1 | 1999-04-22 | |||
| WO2008061795A2 | 2008-05-29 | |||
| WO2004092155A1 | 2004-10-28 | |||
| WO2004033439A1 | 2004-04-22 |
Foreign References:
| DE10010429A1 | 2001-09-06 |
Other References:
WHITE,G.A. ET AL.: "Thiophene carboxamide fungicides: structure-activity relationships with the succinate dehydrogenase complex from wild-type and carboxin-resistant mutant strains of Aspergillus nidulans", PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY, vol. 25, no. 2, 1986, pages 188 - 204
Attorney, Agent or Firm:
TAKAYAMA, Hirotsugu et al. (JP)
Hiromitsu Takayama (JP)
Hiromitsu Takayama (JP)
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