REMINERALISATION AND ELIMINATES LESION PAIN

Related Technical Field The present invention relates to a pharmaceutical solution that eliminates swiftly and effectively the pain caused by lesions by means of facilitating dental remineralization through a brilliant extract.

State of the Art Non-steroidal anti-inflammatory drugs (NSAIDs) or painkillers used nowadays for tooth pain are commonly available in the market. Those included in the non-steroidal anti-inflammatory drugs have common properties in terms of tooth pain. Painkillers are used also for tooth pain, whereas they are not intended to be used for tooth pain.

Since some products in the state of the art and available in the market and marketed so as to bring a solution for toothache are not suitable for tooth structure, causes irritation on the tooth, and leads to tooth loses, they do not exhibit a healthy function.

Oral rinse used for oral care and dental health is a solution that comprises a content eliminating the imbalance occurring due to the excessive pressure increase in veins in dental channels and easing the toothache by means of ensuring the oral rinse.

The brilliant feature of the oral rinse solution is that the ingredients thereof are purified properly, thereby achieving a function that balances the pressure occurring in the dental vein, which causes a toothache. However, toothaches may not occur just because of the pressure on nerves in the dental channel. Therefore, when considering that the tooth is affected by hot or cold medium, the solution is brought to a proper condition by means of every condition planned through experimental conditions. Furthermore, it exhibits an advantageous feature compared to those marketed for fractures, irritations, etc. on the tooth. Said feature contains substances that ensure herbal support in terms of the mineral needed by tooth and are brought to a more useful condition by means of experimental purification and cleaning.

Advantages and Technical Solutions Provided by the Invention

The inventive solution is a medical pharmaceutical solution to be used in oral health and to eliminate the toothache by means of developing scientifically the method in the state of the art.

The inventive solution is useful and practical in terms of both pharmaceutical and dental structure by means of the chemical ingredients therein and the proper preparation of herbal functions, wherein it exhibits a function that is to be used to bring a solution for a toothache, is suitable for dental structure, causes no irritation on the tooth and leads to no dental loss.

An object of the present invention is to eliminate lesions such as germs in the mouth, bacteria, streptococcus, etc. affecting negatively the oral health and causing tooth decay and to provide a novel product that brings an effective solution for tooth pain.

Another object of the present invention is to provide a useful product for the dental both pharmaceutically and herbally. Another object of the present invention is to facilitate the remineralization on the dental layer and to exhibit a direct effect on oral health by complying with the inside of the mouth. Said effect of the oral rinse solution is ensured by means of the brilliant feature and is easy and practical in terms of administration. Thus, the present invention ensures to access easily and cheaply such practical effect, when needed.

Another object of the present invention is to contain a significantly useful function when considering the biochemical function of saliva. Furthermore, the brilliant feature and purification techniques in the prepared solution ensures to provide significantly correct results in terms of oral health, since it is required to consider the importance of oral health in daily life and to promote the significance of dental care. Such that, it is a further object to present the invention for the sake of those in need, which ensures the most suitable condition and medium to the dental structure in terms of ingredients of the oral rinse solution since the oral health is extremely significant.

Description of the Invention

The present invention is a pharmaceutical solution prepared through mixing a primary product obtained from reducing and ionizing a compound with an additive provided by agent compound and enzyme for the reaction in the purification stage of the herbal extract with distillation with a secondary product which achieved the brilliant feature by means of the enzyme in another solution prepared through proper solvent and substances. Said pharmaceutical solution is used particularly to improve oral health and to eliminate the toothache. Said primary product is a distillation product that decreases (by means of the enzyme and agent reaction during purifying the extract at certain temperatures) the efficiency of the bacteria, germ, and streptococcus that occur in the mouth. The pharmaceutical solution is achieved (ensuring the brilliant feature to the ingredients and ions therein by means of the thermal treatments and methods) by mixing the secondary product prepared through solvent, enzyme, and compounds at the appropriate pH with the primary product.

The inventive solution is preferred in the form of an oral rinse. Said oral rinse is liquid solutions used to gargle generally the oral surfaces and to form a cleaning and refreshing sense for the user's mouth. Oral rinse is an oral solution administrated in the oral cavity after taking in the mouth and spitted out of the oral cavity afterward.

Compounds used in the preparation of the inventive solution employed to improve the oral health and eliminate the toothache are pharmaceutical, wherein they are examined in terms of their pH value and are also combined by means of the experimental methods. Every condition and medium are provided, that are significant in terms of the dental structure in the experimental methods. Furthermore, giving that every sort of harmful bacteria and germs occurring in the oral cavity causes damages to the dental structure, every sort of conditions and mediums to eliminate the harmful bacteria and germs and to clean the mouth is embodied experimentally.

The present invention is a solution that facilitates dental remineralization, balances the pressure causing the gingival and dental layer pain by complying with the oral cavity, and exhibits a direct effect on toothache. The inventive pharmaceutical solution is achieved by combining multiple solutions. The following process steps are implemented in achieving the pharmaceutical solution; extracting the sap of the Platanus plant, - purifying the solution obtained through collecting the plant extract of 200 ml in the first container with 1- 1.2 g Mg(OH)2 therein and precipitating the heavy metal, achieving the primary solution in the first container after removing the precipitated heavy metals by means of decantation, distilling the primary solution at less than 70 °C and achieving the secondary solution in the first container by introducing 2-4 ml, or 1.5-2 g of dehydrogenase enzyme catalyzing the (CH-NH2) bond or 1-2 g of aniline to the first solution in the first container during the distillation process, reducing the PABA (p-aminobenzoic acid) components of 0.4-0.6 g to prevent the bacterial occurrence during the distillation process implemented for achieving the secondary solution, starting to enrich the secondary solution with the brilliant feature, wherein PABA compound is recognized with the aniline agent compound and reduced through the dehydrogenase enzyme catalyzing the (CH-NH2) bond, - adding eugenol of 2.5-3 ml in the empty secondary container and under cold environment conditions (under 0 CO) and solving the same with a certain amount of diethyl ether and achieving the third solution in the secondary container by titrating the mixture obtained after adding Na2HPC>4 of 0.5-1 g therein with KOH of 0.01 M, solving monolaurin of 2-3 ml with a certain amount of pyridine in a third empty container and a hot environment and adding NaF of 0.8-1.2 g therein and achieving the fourth solution in the third container by titrating the obtained mixture with Ca(OH)2 of 0.01 M, achieving the fifth solution by means of adding the third and fourth solution on the oxidase enzyme of 3-4 ml or 2-3g affecting on sulphonyl amide of 0.5-0.65 g and the (OH) group in a fourth empty container, enriching the obtained fifth solution with the brilliant feature by forming a thin layer on the tooth surface by means of rendering the structural similarity (the structural similarity of PABA and sulphonyl amide) appropriate to the dental structure after oxidating the sulphonyl amide (affecting the OH group) through the oxidase enzyme, mixing homogeneously the second solution and fifth solution together and keeping at a temperature (40-60 °C) under proper thermal treatments.

The second solution achieved in the process steps is the first product that constitutes the inventive pharmaceutical solution. The second product is achieved through reducing and ionizing a compound by means of the contribution provided by the agent compound and enzyme in the purification stage of an herbal extract through distillation.

The fifth solution achieved in the process steps is the second product that constitutes the inventive pharmaceutical solution. The second product is a solution enriched with the brilliant feature by means of the enzyme in another solution constituted by a proper solution and substances.

It is started to enrich the second solution with the brilliant feature, wherein it is reduced by means of the dehydrogenase enzyme catalyzing the bond CH-NH ₂ by way of recognizing the PABA compound of the achieved second product with the agent compound (aniline) and the brilliant feature is concluded by forming a thin layer on the tooth surface by means of rendering the structural similarity appropriate to the tooth structure after oxidating the second product through the oxidase enzyme affecting on the OH group of sulphonyl amide.

The achieved second product contains a brilliant feature. Said pharmaceutical solution facilitates the dental remineralization, heals mouth sores, and balances the pressure in the dental veins by equalizing the effect mechanism of streptococcus, germs, lactobacillus, actinomycosis, and other harmful bacteria by means of exhibiting a pharmaceutical effect, that causes mouth sore.

The brilliant feature of said second product is for providing the ion balance between the dental layer and oral cavity and ensuring that compounds used in easing the toothache that increases due to the excessive pressure in the nerves and veins in the dental channel exhibit a direct effect.

The inventive pharmaceutical solution facilitates to enrich of the second product with the brilliant feature and also the dental remineralization through its alkali structure and exhibits a saliva-like effect on the dental layer.

The brilliant feature of the second product is for exhibiting an activity on the dental layer by means of proper solution and enzymes and for ensuring the ion balance in the oral cavity by means of the method implemented on the compounds. Said pharmaceutical solution is a novel oral rinse with a pharmaceutical effect by means of decreasing the activity of bacteria, germs, and streptococcus in the mouth and making a significant contribution to cleaning the oral cavity.

Said pharmaceutical solution is an oral solution administrated in the oral cavity after taking in the mouth and afterward spitted out of the oral cavity, wherein it is an oral rinse.

The adaptability of said oral rinse to the oral cavity is for preventing the oral cavity dryness by means of the compounds in the solution and for exhibiting an acid balancing effect in the mouth.

Said pharmaceutical solution is a medication used as an oral rinse as of the beginning of the toothache and allowing for a direct effect on the dental layer.

It is known that the plant Platanus is good for toothache and strengthens the gingiva. It is proved by means of various studies that it is useful not only for tooth and gingiva but also exhibits several useful functions (rheumatic diseases, nephritis, vomiting, osteoarthritis, etc.). The plant Platanus is used as an antirheumatic, astringent, diuretic, emetic, laxative, poultice, and salve. Lea of the plant Platanus exhibits edema, swelling, and nausea-preventive effects and further helps wounds to heal swiftly. Said plant is a plant that helps treat osteoarthritis and bone pains and heal dermatological diseases.

In the present invention, it is ensured that the extract of Platanus (Plane tree) is purified through the extraction device. In the purification process, the solid magnesium hydroxide (MgOH2) is used in the extraction process, since MgOH2 is both an acid regulator and partial rennet promoter, it ensures coagulation and it is ensured thus that heavy metals in the plant extract are precipitated and the compound PABA is provided for the reaction between the reduction enzyme and the agent compound. Thus, useful minerals and substances such as calcium, magnesium, zinc, potassium, the phosphor in the Platanus extract are achieved.

The achieved extract is purified for a second time at a certain temperature (40-70 °C) through distillation. It is started to enrich the solution with the brilliant feature, wherein it is reduced by means of the enzyme by way of recognizing the PABA compound of the achieved second product with the agent compound and the brilliant feature is concluded by forming a thin layer on the tooth surface by means of rendering the structural similarity appropriate to the tooth structure after oxidating the sulphonyl amide through the enzyme. This means to provide a proper environment for contacting the minerals and other useful substances with the tooth, which are to ensure the relief on the dental structure by means of eliminating all sort of bacteria and germs causing tooth pain. By means of this feature, it is ensured to facilitate the remineralization by forming a superficial interaction between the tooth and useful minerals and substances after eliminating bacteria and germs causing tooth pain.

The compound PABA is used in the step of starting to enrich the solution with the brilliant feature and the sulphonyl amide is used in the step of concluding the brilliant feature. The reason why the compound PABA and sulphonyl amide is used in the process sequence is that the compound PABA and sulphonyl amide exhibit an antimetabolite effect against each other. In the process implemented, the compound PABA is reduced through the dehydrogenase enzyme catalyzing the bond (CH-NH2).

Said enzyme is also an enzyme carrying hydrogen and is used with the compound aniline. Because aniline is similar to both PABA and sulphonyl amide in terms of its structure. Said similarity facilitates the recognition of compounds that are attracted structurally. While performing all these processes, in another stage, namely in the step, wherein the brilliant feature is concluded and the structural similarity is rendered appropriate for the dental surface and oral cavity, it is ensured to oxidate sulphonyl amide. Said process is performed by way of using the oxidase enzyme affecting the (OH) group with sulphonyl amide.

It is commonly known that the substance Eugenol prevents toothache. Eugenol is an anti-inflammatory, antioxidant, antifungal, and neuroprotective substance that is available in the clove oil and known for its disinfectant feature. Eugenol is used under cold environment conditions (under 0 CO). While performing experimental processes, Eugenol that eases tooth pain is used, wherein an antibacterial solution is achieved by means of titration method under cold environment condition, whose pH value and compound are suitable for the dental structure. It is generally known that Monolaurin heals oral wounds. Monolaurin is a strong antimicrobial, a natural preservative, and a biofilm disruptor, which is available in coconut oil. A solution with a healing property is achieved with Monolaurin through the titration method under the hot environment conditions (50-60°C), which is adaptable to the oral cavity by means of its composition. The reason why these prepared solutions are implemented under different temperature conditions (both under 0 °C and above 50 °C) is to provide the optimum condition and environment so as to ease the tooth pain and to heal the oral wounds. Planning is carried out at temperatures defined to achieve the full efficiency and the maximum benefit from the substances used in the reaction conditioned as above, by considering the state of every substance. When the processes of reducing the compound PABA and of oxidating sulphonyl amide is performed by means of the oxidoreductase enzymes (catalyzing the bond CH-NH2 and affecting the OH group), the occurrence of streptococcus, germs, lactobacillus, actinomycosis, and other harmful bacteria is limited. Remineralization is initiated through said brilliant feature, thereby ensuring the ion balance in the dental veins and easing the tooth pain. Substances comprising pharmaceutical compounds such as Eugenol, Monolaurin, the plant Platanus, disodium phosphate, sodium fluoride, Mg (OH)2, KOH, Ca(OH)2 are useful both for healing the oral wounds and for eliminating toothache. Said useful effect is an effect that balances the pressure in veins pressing on the dental nerves in the tooth channels in the technique. The pharmaceutically optimum compound and substances are chosen in said processes and techniques, wherein optimum amounts of all compounds or chemicals are used for the oral cavity and dental structure.