Title:
PHARMACEUTICAL USE AND PREPARATION METHOD FOR SUBSTITUTED HETEROARYL PHTHALAZINE DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2023/051761
Kind Code:
A1
Abstract:
Provided are a substituted heteroaryl phthalazine derivative as shown in formula (I-0), a use thereof as an NLRP3 inhibitor, and a preparation method therefor; the derivative has relatively good NLRP3 inhibitory activity.
Inventors:
HUANG QI (CN)
WAN SONGLIN (CN)
LIU GUOLIANG (CN)
XIONG YIFENG (CN)
WU XIAOQUAN (CN)
WAN SONGLIN (CN)
LIU GUOLIANG (CN)
XIONG YIFENG (CN)
WU XIAOQUAN (CN)
Application Number:
PCT/CN2022/123126
Publication Date:
April 06, 2023
Filing Date:
September 30, 2022
Export Citation:
Assignee:
ORIGIANT PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D403/02; A61K31/501; A61K31/502; A61P3/10; A61P19/02; A61P35/00; C07D237/20; C07D409/14
Domestic Patent References:
| WO2022216971A1 | 2022-10-13 | |||
| WO2022135567A1 | 2022-06-30 | |||
| WO2018080216A1 | 2018-05-03 | |||
| WO2007066615A1 | 2007-06-14 | |||
| WO2018221433A1 | 2018-12-06 | |||
| WO2020234715A1 | 2020-11-26 |
Foreign References:
| US20110160187A1 | 2011-06-30 | |||
| US3753988A | 1973-08-21 | |||
| US5324727A | 1994-06-28 |
Attorney, Agent or Firm:
MERITS IP LTD. (CN)
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